Loss of miR-145 promotes remyelination and functional recovery in a model of chronic central demyelination.

Autor: Kornfeld SF; Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada.; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, K1H 8M5, Canada., Cummings SE; Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada.; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, K1H 8M5, Canada., Yaworski R; Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada.; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, K1H 8M5, Canada., De Repentigny Y; Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada., Gagnon S; Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada., Zandee S; Neuroimmunology Unit and Multiple Sclerosis Clinic, The Research Center of the Centre Hospitalier de l'Université de Montréal (CRCHUM), Department of Neuroscience, Faculty of Medicine, Université de Montréal, Montréal, QC, Canada., Fathi S; Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada., Prat A; Neuroimmunology Unit and Multiple Sclerosis Clinic, The Research Center of the Centre Hospitalier de l'Université de Montréal (CRCHUM), Department of Neuroscience, Faculty of Medicine, Université de Montréal, Montréal, QC, Canada., Kothary R; Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada. rkothary@ohri.ca.; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, K1H 8M5, Canada. rkothary@ohri.ca.; Department of Medicine, University of Ottawa, Ottawa, ON, K1H 8M5, Canada. rkothary@ohri.ca.; Centre for Neuromuscular Disease, University of Ottawa, Ottawa, ON, K1H 8M5, Canada. rkothary@ohri.ca.

Publikováno v: Communications biology [Commun Biol] 2024 Jul 04; Vol. 7 (1), pp. 813. Date of Electronic Publication: 2024 Jul 04.

Optimization of base editors for the functional correction of SMN2 as a treatment for spinal muscular atrophy.

Autor: Alves CRR; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA. calves2@mgh.harvard.edu.; Department of Neurology, Massachusetts General Hospital, Boston, MA, USA. calves2@mgh.harvard.edu.; Department of Neurology, Harvard Medical School, Boston, MA, USA. calves2@mgh.harvard.edu., Ha LL; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Pathology, Massachusetts General Hospital, Boston, MA, USA., Yaworski R; Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada.; Centre for Neuromuscular Disease, University of Ottawa, Ottawa, Ontario, Canada., Sutton ER; Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada.; Centre for Neuromuscular Disease, University of Ottawa, Ottawa, Ontario, Canada., Lazzarotto CR; Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN, USA., Christie KA; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Pathology, Massachusetts General Hospital, Boston, MA, USA.; Department of Pathology, Harvard Medical School, Boston, MA, USA., Reilly A; Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada.; Centre for Neuromuscular Disease, University of Ottawa, Ottawa, Ontario, Canada., Beauvais A; Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada.; Centre for Neuromuscular Disease, University of Ottawa, Ottawa, Ontario, Canada., Doll RM; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Pathology, Massachusetts General Hospital, Boston, MA, USA.; Molecular Biosciences/Cancer Biology Program, Heidelberg University and German Cancer Research Center (DKFZ), Heidelberg, Germany., de la Cruz D; Molecular Neurogenetics Unit, Department of Neurology, Massachusetts General Hospital, Charlestown, MA, USA.; Program in Neuroscience, Harvard Medical School, Boston, MA, USA., Maguire CA; Molecular Neurogenetics Unit, Department of Neurology, Massachusetts General Hospital, Charlestown, MA, USA.; Program in Neuroscience, Harvard Medical School, Boston, MA, USA., Swoboda KJ; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.; Department of Neurology, Harvard Medical School, Boston, MA, USA., Tsai SQ; Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN, USA., Kothary R; Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada.; Centre for Neuromuscular Disease, University of Ottawa, Ottawa, Ontario, Canada.; Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada., Kleinstiver BP; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA. bkleinstiver@mgh.harvard.edu.; Department of Pathology, Massachusetts General Hospital, Boston, MA, USA. bkleinstiver@mgh.harvard.edu.; Department of Pathology, Harvard Medical School, Boston, MA, USA. bkleinstiver@mgh.harvard.edu.

Publikováno v: Nature biomedical engineering [Nat Biomed Eng] 2024 Feb; Vol. 8 (2), pp. 118-131. Date of Electronic Publication: 2023 Dec 06.

Central and peripheral delivered AAV9-SMN are both efficient but target different pathomechanisms in a mouse model of spinal muscular atrophy.

Autor: Reilly A; Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, Canada.; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Canada.; Centre for Neuromuscular Disease, University of Ottawa, Ottawa, Canada., Deguise MO; Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, Canada.; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Canada.; Centre for Neuromuscular Disease, University of Ottawa, Ottawa, Canada., Beauvais A; Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, Canada., Yaworski R; Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, Canada., Thebault S; Division of Neurology, Department of Medicine, The Ottawa Hospital, Ottawa, Canada.; Department of Medicine, University of Ottawa, Ottawa, Canada., Tessier DR; Department of Physics, University of Ottawa, Ottawa, Canada., Tabard-Cossa V; Department of Physics, University of Ottawa, Ottawa, Canada., Hensel N; Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, Canada.; Centre for Neuromuscular Disease, University of Ottawa, Ottawa, Canada., Schneider BL; Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.; Bertarelli Platform for Gene Therapy, Ecole Polytechnique Fédérale de Lausanne, Geneva, Switzerland., Kothary R; Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, Canada. rkothary@ohri.ca.; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Canada. rkothary@ohri.ca.; Centre for Neuromuscular Disease, University of Ottawa, Ottawa, Canada. rkothary@ohri.ca.; Department of Medicine, University of Ottawa, Ottawa, Canada. rkothary@ohri.ca.

Publikováno v: Gene therapy [Gene Ther] 2022 Sep; Vol. 29 (9), pp. 544-554. Date of Electronic Publication: 2022 Apr 25.

Hepatic Choline Transport Is Inhibited During Fatty Acid-Induced Lipotoxicity and Obesity.

Autor: O'Dwyer C; Department of Biochemistry, Microbiology and Immunology Faculty of Medicine University of Ottawa Ottawa ON Canada.; Centre for Infection Immunity and Inflammation and Centre for Catalysis Research and Innovation University of Ottawa Ottawa ON Canada., Yaworski R; Department of Biochemistry, Microbiology and Immunology Faculty of Medicine University of Ottawa Ottawa ON Canada.; Centre for Infection Immunity and Inflammation and Centre for Catalysis Research and Innovation University of Ottawa Ottawa ON Canada., Katsumura S; Department of Molecular Medicine University of Texas Health Science Center at San Antonio San Antonio TX., Ghorbani P; Department of Biochemistry, Microbiology and Immunology Faculty of Medicine University of Ottawa Ottawa ON Canada.; Centre for Infection Immunity and Inflammation and Centre for Catalysis Research and Innovation University of Ottawa Ottawa ON Canada., Gobeil Odai K; Department of Biochemistry, Microbiology and Immunology Faculty of Medicine University of Ottawa Ottawa ON Canada.; Centre for Infection Immunity and Inflammation and Centre for Catalysis Research and Innovation University of Ottawa Ottawa ON Canada., Nunes JRC; Department of Biochemistry, Microbiology and Immunology Faculty of Medicine University of Ottawa Ottawa ON Canada.; Centre for Infection Immunity and Inflammation and Centre for Catalysis Research and Innovation University of Ottawa Ottawa ON Canada., LeBlond ND; Department of Biochemistry, Microbiology and Immunology Faculty of Medicine University of Ottawa Ottawa ON Canada.; Centre for Infection Immunity and Inflammation and Centre for Catalysis Research and Innovation University of Ottawa Ottawa ON Canada., Sanjana S; Department of Biochemistry, Microbiology and Immunology Faculty of Medicine University of Ottawa Ottawa ON Canada.; Centre for Infection Immunity and Inflammation and Centre for Catalysis Research and Innovation University of Ottawa Ottawa ON Canada., Smith TTK; Department of Biochemistry, Microbiology and Immunology Faculty of Medicine University of Ottawa Ottawa ON Canada.; Centre for Infection Immunity and Inflammation and Centre for Catalysis Research and Innovation University of Ottawa Ottawa ON Canada., Han S; Department of Biochemistry, Microbiology and Immunology Faculty of Medicine University of Ottawa Ottawa ON Canada.; Centre for Infection Immunity and Inflammation and Centre for Catalysis Research and Innovation University of Ottawa Ottawa ON Canada., Margison KD; Department of Biochemistry, Microbiology and Immunology Faculty of Medicine University of Ottawa Ottawa ON Canada.; Centre for Infection Immunity and Inflammation and Centre for Catalysis Research and Innovation University of Ottawa Ottawa ON Canada., Alain T; Department of Biochemistry, Microbiology and Immunology Faculty of Medicine University of Ottawa Ottawa ON Canada.; Centre for Infection Immunity and Inflammation and Centre for Catalysis Research and Innovation University of Ottawa Ottawa ON Canada.; Children's Hospital of Eastern Ontario Research Institute Ottawa ON Canada., Morita M; Department of Molecular Medicine University of Texas Health Science Center at San Antonio San Antonio TX.; Barshop Institute for Longevity and Aging Studies University of Texas Health Science Center at San Antonio San Antonio TX.; Institute of Resource Development and Analysis Kumamoto University Kumamoto Japan., Fullerton MD; Department of Biochemistry, Microbiology and Immunology Faculty of Medicine University of Ottawa Ottawa ON Canada.; Centre for Infection Immunity and Inflammation and Centre for Catalysis Research and Innovation University of Ottawa Ottawa ON Canada.

Publikováno v: Hepatology communications [Hepatol Commun] 2020 Apr 10; Vol. 4 (6), pp. 876-889. Date of Electronic Publication: 2020 Apr 10 (Print Publication: 2020).

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