Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Yavuz Ergun"'
Autor:
Seher Aydın, Yavuz Ergün, Salma Ghazy, Asuman Çelebi, Turker Kilic, Timuçin Avşar, Serdar Durdağı
Publikováno v:
ACS Omega, Vol 9, Iss 44, Pp 44262-44281 (2024)
Externí odkaz:
https://doaj.org/article/c6f1a1c015fe4736b95a0fe9e3449c86
Publikováno v:
Russian Journal of Organic Chemistry. 57:1330-1335
The octahydropyridocarbazole skeleton is an important key structure for the synthesis of pyridocarbazole alkaloids, including the antineoplastic agent ellipticine and related compounds. In the present work, an octahydropyrido[3,4-b]carbazole derivati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a17af7f33a16d8944e66dba927bbc1ac
https://doi.org/10.1134/s1070428021080133
https://doi.org/10.1134/s1070428021080133
A series of novel murrayaquinone a derivatives were synthesized and their anti-cancer activity were evaluated on healthy colon cell lines (CCD-18Co), primary (Caco-2) and metastatic (DLD-1) colon cancer cell lines. The results showed that the cytotox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f68edbbc5abde43e21059a02e91d11be
https://aperta.ulakbim.gov.tr/record/234308
https://aperta.ulakbim.gov.tr/record/234308
Autor:
Timucin Avsar, Berfu Nur Yigit, Gizem Turan, Deniz Altunsu, Seyma Calis, Bahar Kurt, Turker Kilic, M. Yavuz Ergun, Serdar Durdagi, Melih Acar
Cell cycle inhibitors are considered as hallmark strategy for cancer treatment due to their relatively higher selectivity and efficacy on various cancer types in comparison to cytotoxic agents. Small molecules target dividing cells in G1/S, G2 or M p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6134751a9817f862c51951372906e2c5
https://avesis.deu.edu.tr/publication/details/44bd8985-e406-430c-9d1e-c242e59ab859/oai
https://avesis.deu.edu.tr/publication/details/44bd8985-e406-430c-9d1e-c242e59ab859/oai
Autor:
Yavuz Ergun, Serdar Durdagi, Zeki Topcu, Á. Kulmány, M. Zaka, Kader Sahin, István Zupkó, Sevil Zencir, M. Kuskucu, V. Akyildiz, Hilmi Orhan
The compounds reducing tumor cell viability and disrupting DNA topoisomerase reactions have been widely used in anticancer drug development. Ellipticine (5,11-dimethyl-6H-pyrido[4,3-b]carbazole) is a potent intercalating agent that interferes with nu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b2de3987d1a58efe767ceaedadbde0b
https://avesis.deu.edu.tr/publication/details/9e8b704c-2c4e-4d59-922b-200d244321d7/oai
https://avesis.deu.edu.tr/publication/details/9e8b704c-2c4e-4d59-922b-200d244321d7/oai
Autor:
Sevil, Zencir, Meng-Hsun, Hsieh, Joel-Sean, Hsu, Yavuz, Ergun, Guan-Ling, Chou, Tsai-Kun, Li, Shu-Chun, Teng, Zeki, Topcu
Publikováno v:
Journal of cancer research and clinical oncology. 146(7)
DNA topoisomerase and telomerase enzymes are popular targets of several anti-tumor drugs. Smooth proceeding of telomeric recombination requires Topoisomerase II (Top2), which is involved in telomere-telomere recombination through functioning in relax
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::af178eb8e0201bba3844264a2aa6e6d1
https://pubmed.ncbi.nlm.nih.gov/32333143
https://pubmed.ncbi.nlm.nih.gov/32333143
Autor:
Joel-Sean Hsu, Yavuz Ergun, Sevil Zencir, Zeki Topcu, Guan-Ling Chou, Meng-Hsun Hsieh, Shu-Chun Teng, Tsai-Kun Li
Background DNA topoisomerase and telomerase enzymes are popular targets of several anti-tumor drugs. Smooth proceeding of telomeric recombination requires Topoisomerase II (Top2), which is involved in telomere-telomere recombination through functioni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c0b048c1d0e38533aa90570de7e4a71
https://aperta.ulakbim.gov.tr/record/5665
https://aperta.ulakbim.gov.tr/record/5665
Autor:
George Liapakis, Sara Alkhatib, Yavuz Ergun, Berfu Nur Yigit, Gülay Bulut, Melih Acar, Busecan Aksoydan, Ismail Erol, Ramin Ekhteiari Salmas, Bahar Kurt, Vlasios Karageorgos, Turker Kilic, Isik Kantarcioglu, Kutay Cantasir, Serdar Durdagi, Gizem Turan, Timuçin Avşar, Barış Sergi
Publikováno v:
European Journal of Medicinal Chemistry. 145:273-290
AT1 antagonists is the most recent drug class of molecules against hypertension and they mediate their actions through blocking detrimental effects of angiotensin II (A-II) when acts on type I (AT1) A-II receptor. The effects of AT1 antagonists are n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e08fe56a07c296e06a0ef5b2e96481ab
https://doi.org/10.1016/j.ejmech.2017.12.021
https://doi.org/10.1016/j.ejmech.2017.12.021
Acetylcholine esterase (AChE) is one of the targeted enzymes in the therapy of important neurodegenerative diseases such as Alzheimer's disease. Many studies on carbazole- and oxazolone-based compounds have been conducted in the last decade due to th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73dbddd74d755faea221b839cb5fa11c
https://avesis.deu.edu.tr/publication/details/f0e74122-1f4a-483d-9ee1-9b4e29f517a5/oai
https://avesis.deu.edu.tr/publication/details/f0e74122-1f4a-483d-9ee1-9b4e29f517a5/oai
Publikováno v:
Journal of Heterocyclic Chemistry. 53:767-770
A new synthetic route for the synthesis of 5-methyl-6H-pyrido[4,3-b]carbazole (8), so-called 11-demethylellipticine, was described. Construction of the tetracyclic structure hexahydro-1H-pyrido[4,3-b]carbazol-5(6H)-one skeleton (6) was also achieved
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b029cac3bbebddb571316a0f39802ddc
https://doi.org/10.1002/jhet.2366
https://doi.org/10.1002/jhet.2366