Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Yau-Tuen Chan"'
Autor:
Junyu Wu, Guoyi Tang, Chien-Shan Cheng, Ranna Yeerken, Yau-Tuen Chan, Zhiwen Fu, Yi-Chao Zheng, Yibin Feng, Ning Wang
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-27 (2024)
Abstract Hepatic, biliary, and pancreatic cancer pose significant challenges in the field of digestive system diseases due to their highly malignant nature. Traditional Chinese medicine (TCM) has gained attention as a potential therapeutic approach w
Externí odkaz:
https://doaj.org/article/867c45ebbbcd4f019051d6418fc38d44
Autor:
Yau-Tuen Chan, Cheng Zhang, Junyu Wu, Pengde Lu, Lin Xu, Hongchao Yuan, Yibin Feng, Zhe-Sheng Chen, Ning Wang
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-39 (2024)
Abstract Liver cancer is a global health challenge, causing a significant social-economic burden. Hepatocellular carcinoma (HCC) is the predominant type of primary liver cancer, which is highly heterogeneous in terms of molecular and cellular signatu
Externí odkaz:
https://doaj.org/article/e1932c66aa874b9aa436a72a5f569c9d
Autor:
Zipan Lyu, Yau-Tuen Chan, Yuanjun Lu, Tsz Fung Lam, Xingyao Wu, Junyu Wu, Lin Xu, Wei Yang, Cheng Zhang, Linda Lidan Zhong, Ning Wang
Publikováno v:
Journal of Advanced Research, Vol 62, Iss , Pp 245-255 (2024)
Introduction: Adipogenesis, the process of white adipose tissue expansion, plays a critical role in the development of obesity. Osteoprotegerin (OPG), known for its role in bone metabolism regulation, emerges as a potential regulator in mediating adi
Externí odkaz:
https://doaj.org/article/48c080fe1c3a44beb3cd218dd4ab2485
Autor:
Yau-Tuen Chan, Junyu Wu, Yuanjun Lu, Qiucheng Li, Zixin Feng, Lin Xu, Hongchao Yuan, Tingyuan Xing, Cheng Zhang, Hor-Yue Tan, Yibin Feng, Ning Wang
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-16 (2024)
Abstract Background and aims Sorafenib is a major nonsurgical option for patients with advanced hepatocellular carcinoma (HCC); however, its clinical efficacy is largely undermined by the acquisition of resistance. The aim of this study was to identi
Externí odkaz:
https://doaj.org/article/19f11ffb26aa412a8da62d2485479475
Autor:
Junyu Wu, Hor-Yue Tan, Yau-Tuen Chan, Yuanjun Lu, Zixin Feng, Hongchao Yuan, Cheng Zhang, Yibin Feng, Ning Wang
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-17 (2024)
Abstract Background Par-3 Family Cell Polarity Regulator (PARD3) is a cellular protein essential for asymmetric cell division and polarized growth. This study aimed to study the role of PARD3 in hepatic tumorigenesis. Methods The essential role of PA
Externí odkaz:
https://doaj.org/article/30e5f01326084773a84fb32e1af2100b
Autor:
Yuanjun Lu, Yazhou Liu, Junjie Lan, Yau-Tuen Chan, Zixin Feng, Lan Huang, Ning Wang, Weidong Pan, Yibin Feng
Publikováno v:
Journal of Advanced Research, Vol 51, Iss , Pp 181-196 (2023)
Introduction: Hyperactivated histone deacetylases (HDACs) act as epigenetic repressors on gene transcription and are frequently observed in human hepatocellular carcinoma (HCC). Although multiple pharmacological HDAC inhibitors (HDACis) have been dev
Externí odkaz:
https://doaj.org/article/0389185bf33d4f22a191ce47360d7517
Autor:
Yau-tuen Chan, Hor-yue Tan, Yuanjun Lu, Cheng Zhang, Chien-shan Cheng, Junyu Wu, Ning Wang, Yibin Feng
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 4, Pp 1554-1567 (2023)
Tumor microenvironment contributes to poor prognosis of pancreatic adenocarcinoma (PAAD) patients. Proper regulation could improve survival. Melatonin is an endogenous hormone that delivers multiple bioactivities. Here we showed that pancreatic melat
Externí odkaz:
https://doaj.org/article/6ab1069a71a148088ee65f74f5818e18
Autor:
Cheng Zhang, Guoming Chen, Guoyi Tang, Xiaoyu Xu, Zixin Feng, Yuanjun Lu, Yau-Tuen Chan, Junyu Wu, Yuanyuan Chen, Lin Xu, Qing Ren, Hongchao Yuan, Dong-Hua Yang, Zhe-Sheng Chen, Ning Wang, Yibin Feng
Publikováno v:
Acta Materia Medica, Vol 2, Iss 1, Pp 106-125 (2023)
For hundreds of years, the drug discovery and development industry has aimed at identifying single components with a clear mechanism of action as desirable candidates for potential drugs. However, this conventional strategy of drug discovery and deve
Externí odkaz:
https://doaj.org/article/3bbf4451b9ad4428993aa1d7704240e6
Autor:
Guoming Chen, Dongqiang Luo, Xiangjun Qi, Danyun Li, Jiyuan Zheng, Yang Luo, Cheng Zhang, Qing Ren, Yuanjun Lu, Yau-Tuen Chan, Bonan Chen, Junyu Wu, Ning Wang, Yibin Feng
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Gastric cancer (GC) is the fifth most common cancer worldwide. Cuproptosis is associated with cell growth and death as well as tumorigenesis. Aiming to lucubrate the potential influence of CRGs in gastric cancer, we acquired datasets of gastric cance
Externí odkaz:
https://doaj.org/article/24e036d17017461ca65658135fd75758
Autor:
Yuanjun Lu, Yau-Tuen Chan, Hor-Yue Tan, Cheng Zhang, Wei Guo, Yu Xu, Rakesh Sharma, Zhe-Sheng Chen, Yi-Chao Zheng, Ning Wang, Yibin Feng
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-17 (2022)
Abstract Background Drug resistance to sorafenib greatly limited the benefits of treatment in patients with hepatocellular carcinoma (HCC). MicroRNAs (miRNAs) participate in the development of drug resistance. The key miRNA regulators related to the
Externí odkaz:
https://doaj.org/article/c6716c82b15d4a1198f87fe713035cd7