Polo-like kinase 4 inhibitor CFI-400945 suppresses liver cancer through cell cycle perturbation and eliciting antitumor immunity.

Autor: Chan CY; Department of Pathology , The University of Hong Kong , Hong Kong SAR , China.; Centre for Oncology and Immunology , Hong Kong Science Park , Hong Kong SAR , China., Yuen VW; Department of Pathology , The University of Hong Kong , Hong Kong SAR , China.; Centre for Oncology and Immunology , Hong Kong Science Park , Hong Kong SAR , China., Chiu DK; Department of Pathology , The University of Hong Kong , Hong Kong SAR , China., Goh CC; Department of Pathology , The University of Hong Kong , Hong Kong SAR , China., Thu KL; The Campbell Family Institute for Breast Cancer Research , Princess Margaret Cancer Centre , Toronto , Ontario , Canada., Cescon DW; The Campbell Family Institute for Breast Cancer Research , Princess Margaret Cancer Centre , Toronto , Ontario , Canada., Soria-Bretones I; The Campbell Family Institute for Breast Cancer Research , Princess Margaret Cancer Centre , Toronto , Ontario , Canada., Law CT; Department of Pathology , The University of Hong Kong , Hong Kong SAR , China., Cheu JW; Department of Pathology , The University of Hong Kong , Hong Kong SAR , China.; Centre for Oncology and Immunology , Hong Kong Science Park , Hong Kong SAR , China., Lee D; Department of Pathology , The University of Hong Kong , Hong Kong SAR , China.; Centre for Oncology and Immunology , Hong Kong Science Park , Hong Kong SAR , China., Tse AP; Department of Pathology , The University of Hong Kong , Hong Kong SAR , China.; Centre for Oncology and Immunology , Hong Kong Science Park , Hong Kong SAR , China., Tan KV; Department of Diagnostic Radiology , The University of Hong Kong , Hong Kong SAR , China., Zhang MS; Department of Pathology , The University of Hong Kong , Hong Kong SAR , China.; Centre for Oncology and Immunology , Hong Kong Science Park , Hong Kong SAR , China., Wong BP; Department of Pathology , The University of Hong Kong , Hong Kong SAR , China., Wong CM; Department of Pathology , The University of Hong Kong , Hong Kong SAR , China.; State Key Laboratory of Liver Research , The University of Hong Kong , Hong Kong SAR , China., Khong PL; Department of Diagnostic Radiology , The University of Hong Kong , Hong Kong SAR , China., Ng IO; Department of Pathology , The University of Hong Kong , Hong Kong SAR , China.; State Key Laboratory of Liver Research , The University of Hong Kong , Hong Kong SAR , China., Bray MR; The Campbell Family Institute for Breast Cancer Research , Princess Margaret Cancer Centre , Toronto , Ontario , Canada., Mak TW; Centre for Oncology and Immunology , Hong Kong Science Park , Hong Kong SAR , China.; The Campbell Family Institute for Breast Cancer Research , Princess Margaret Cancer Centre , Toronto , Ontario , Canada., Yau TC; State Key Laboratory of Liver Research , The University of Hong Kong , Hong Kong SAR , China.; Department of Medicine , The University of Hong Kong , Hong Kong SAR , China., Wong CC; Department of Pathology , The University of Hong Kong , Hong Kong SAR , China.; Centre for Oncology and Immunology , Hong Kong Science Park , Hong Kong SAR , China.; State Key Laboratory of Liver Research , The University of Hong Kong , Hong Kong SAR , China.; Guangdong-Hong Kong Joint Laboratory for RNA Medicine , Sun Yat-Sen University , Guangzhou , China.

Publikováno v: Hepatology (Baltimore, Md.) [Hepatology] 2023 Mar 01; Vol. 77 (3), pp. 729-744. Date of Electronic Publication: 2023 Feb 17.

Clinical and Immunologic Responses to a B-Cell Epitope Vaccine in Patients with HER2/neu-Overexpressing Advanced Gastric Cancer-Results from Phase Ib Trial IMU.ACS.001.

Autor: Wiedermann U; Institute of Specific Prophylaxis and Tropical Medicine, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria. ursula.wiedermann@meduniwien.ac.at., Garner-Spitzer E; Institute of Specific Prophylaxis and Tropical Medicine, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria., Chao Y; Department of Oncology, Taipei Veterans General Hospital, Taipei, Taiwan., Maglakelidze M; ARENSIA Exploratory Medicine LLC, Tbilisi, Georgia., Bulat I; ARENSIA Exploratory Medicine Research Unit, Institute of Oncology, Chisinau, Republic of Moldova., Dechaphunkul A; Department of Medicine, Songklanagarind Hospital, Prince of Songkla University, Hat Yai, Thailand., Arpornwirat W; NCI, Bangkok, Thailand., Charoentum C; Maharaj Nakorn Chiang Mai Hospital, Mueang Chiang Mai District, Thailand., Yen CJ; National Cheng Kung University, Tainan, Taiwan., Yau TC; Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, Hong Kong., Tanasanvimon S; King Chulalongkorn Memorial Hospital, Bangkok, Thailand., Maneechavakajorn J; Rajavithi Hospital, Bangkok, Thailand., Sookprasert A; Srinagarind Hospital, Khon Kaen, Thailand., Bai LY; China Medical University Hospital, Taichung City, Taiwan., Chou WC; Linkou Chang Gung Memorial Hospital, Taoyuan City, Taiwan., Ungtrakul T; Faculty of Medicine and Public Health, HRH Princess Chulabhorn College of Medical Science, Bangkok, Thailand., Drinic M; Institute of Specific Prophylaxis and Tropical Medicine, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria., Tobias J; Institute of Specific Prophylaxis and Tropical Medicine, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria., Zielinski CC; Central European Cooperative Oncology Group, Vienna, Austria., Chong L; Imugene Limited, Sydney, Australia., Ede NJ; Imugene Limited, Sydney, Australia., Marino MT; Imugene Limited, Sydney, Australia., Good AJ; Imugene Limited, Sydney, Australia.

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2021 Jul 01; Vol. 27 (13), pp. 3649-3660. Date of Electronic Publication: 2021 Apr 20.

Targeting TNFR2 for cancer immunotherapy: recent advances and future directions.

Autor: Li, Linxue¹ (AUTHOR), Ye, Ruiwei¹ (AUTHOR), Li, Yingying¹ (AUTHOR), Pan, Hanyu¹ (AUTHOR), Han, Sheng¹ (AUTHOR) hansheng@shu.edu.cn, Lu, Yiming¹ (AUTHOR) bluesluyi@sina.com

Publikováno v: Journal of Translational Medicine. 9/2/2024, Vol. 22 Issue 1, p1-19. 19p.

Hepatocellular Carcinoma Cells Up-regulate PVRL1, Stabilizing PVR and Inhibiting the Cytotoxic T-Cell Response via TIGIT to Mediate Tumor Resistance to PD1 Inhibitors in Mice.

Autor: Chiu DK; Department of Pathology, The University of Hong Kong, Hong Kong., Yuen VW; Department of Pathology, The University of Hong Kong, Hong Kong., Cheu JW; Department of Pathology, The University of Hong Kong, Hong Kong., Wei LL; Department of Pathology, The University of Hong Kong, Hong Kong., Ting V; Department of Medicine, The University of Hong Kong, Hong Kong., Fehlings M; ImmunoSCAPE Pte Ltd, Singapore., Sumatoh H; ImmunoSCAPE Pte Ltd, Singapore., Nardin A; ImmunoSCAPE Pte Ltd, Singapore., Newell EW; ImmunoSCAPE Pte Ltd, Singapore; Vaccine and Infections Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington., Ng IO; Department of Pathology, The University of Hong Kong, Hong Kong; State Key Laboratory of Liver Research, The University of Hong Kong, Hong Kong., Yau TC; Department of Medicine, The University of Hong Kong, Hong Kong; State Key Laboratory of Liver Research, The University of Hong Kong, Hong Kong., Wong CM; Department of Pathology, The University of Hong Kong, Hong Kong; State Key Laboratory of Liver Research, The University of Hong Kong, Hong Kong., Wong CC; Department of Pathology, The University of Hong Kong, Hong Kong; State Key Laboratory of Liver Research, The University of Hong Kong, Hong Kong. Electronic address: carmencl@pathology.hku.hk.

Publikováno v: Gastroenterology [Gastroenterology] 2020 Aug; Vol. 159 (2), pp. 609-623. Date of Electronic Publication: 2020 Apr 08.

Modulating tumor-associated macrophage polarization by anti-maRCO mAb exerts anti-osteosarcoma effects through regulating osteosarcoma cell proliferation, migration and apoptosis.

Autor: Ding, Lei¹, Wu, Ling², Cao, Yuting³, Wang, Hao², Li, Defang¹, Chen, Weibin¹, Huang, Ping² 305836@hospital.cqmu.edu.cn, Jiang, Zengxin³ Dr_Jiangzx@163.com

Publikováno v: Journal of Orthopaedic Surgery & Research. 7/31/2024, Vol. 19 Issue 1, p1-12. 12p.