Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Yau Mun Lim"'
Autor:
Myrianni Constantinou, James Nicholson, Xinyu Zhang, Eleni Maniati, Sara Lucchini, Gabriel Rosser, Claire Vinel, Jun Wang, Yau Mun Lim, Sebastian Brandner, Sven Nelander, Sara Badodi, Silvia Marino
Publikováno v:
Cell Reports, Vol 43, Iss 6, Pp 114309- (2024)
Summary: Glioblastomas are the most common malignant brain tumors in adults; they are highly aggressive and heterogeneous and show a high degree of plasticity. Here, we show that methyltransferase-like 7B (METTL7B) is an essential regulator of lineag
Externí odkaz:
https://doaj.org/article/06de4fe6f43a439db3c5cbbb8e57eff6
Autor:
James Boot, Gabriel Rosser, Dailya Kancheva, Claire Vinel, Yau Mun Lim, Nicola Pomella, Xinyu Zhang, Loredana Guglielmi, Denise Sheer, Michael Barnes, Sebastian Brandner, Sven Nelander, Kiavash Movahedi, Silvia Marino
Publikováno v:
eLife, Vol 11 (2022)
We describe a subset of glioblastoma, the most prevalent malignant adult brain tumour, harbouring a bias towards hypomethylation at defined differentially methylated regions. This epigenetic signature correlates with an enrichment for an astrocytic g
Externí odkaz:
https://doaj.org/article/da3de84103274f4e822d1df1abc6378c
Autor:
Sara Badodi, Nicola Pomella, Xinyu Zhang, Gabriel Rosser, John Whittingham, Maria Victoria Niklison-Chirou, Yau Mun Lim, Sebastian Brandner, Gillian Morrison, Steven M. Pollard, Christopher D. Bennett, Steven C. Clifford, Andrew Peet, M. Albert Basson, Silvia Marino
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
BMI1 and CHD7 are chromatin remodelling genes with a role in medulloblastoma pathogenesis. Here, the authors demonstrate that the BMI1High/CHD7Low signature mediates metabolic adaptation in G4 MB and predicts response to inositol treatment either alo
Externí odkaz:
https://doaj.org/article/e099abd2067e489ba7b766a7107a8238
Autor:
Nicholas J. Ashton, Antoine Leuzy, Yau Mun Lim, Claire Troakes, Tibor Hortobágyi, Kina Höglund, Dag Aarsland, Simon Lovestone, Michael Schöll, Kaj Blennow, Henrik Zetterberg, Abdul Hye
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-11 (2019)
Abstract Alzheimer’s disease (AD) is pathologically characterized by the accumulation of amyloid-β (Aβ) plaques, neurofibrillary tangles and widespread neuronal loss in the brain. In recent years, blood biomarkers have emerged as a realistic pros
Externí odkaz:
https://doaj.org/article/c7a37b8f76d34b138d377df5951aa11b
Autor:
James Boot, Gabriel Rosser, Dailya Kancheva, Claire Vinel, Yau Mun Lim, Nicola Pomella, Xinyu Zhang, Loredana Guglielmi, Denise Sheer, Michael Barnes, Sebastian Brandner, Sven Nelander, Kiavash Movahedi, Silvia Marino
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c90e61c2aaf7947f492d1616ad1a63d
https://doi.org/10.7554/elife.77335.sa2
https://doi.org/10.7554/elife.77335.sa2
Publikováno v:
EpilepsiaREFERENCES. 63(9)
Dysfunctional connectivity and preexisting structural abnormalities of central autonomic network (CAN) regions have been shown on magnetic resonance imaging (MRI) in sudden unexpected death in epilepsy (SUDEP) and may be mechanistically relevant. In
Autor:
Sara Badodi, Nicola Pomella, Yau Mun Lim, Sebastian Brandner, Gillian Morrison, Steven M Pollard, Xinyu Zhang, Nicolae Radu Zabet, Silvia Marino
Publikováno v:
Neuro-oncology. 24(8)
Background Epigenetic changes play a key role in the pathogenesis of medulloblastoma (MB), the most common malignant pediatric brain tumor. Methods We explore the therapeutic potential of BMI1 and MAPK/ERK inhibition in BMI1High;CHD7Low MB cells and
Autor:
James R Boot, Gabriel Rosser, Daliya Kancheva, Claire Vinel, Yau Mun Lim, Nicola Pomella, Xinyu Zhang, Loredana Guglielmi, Denise Sheer, Michael R. Barnes, Sebastian Brandner, Sven Nelander, Kiavash Movahedi, Silvia Marino
We describe a new molecular subgroup of glioblastoma, the most prevalent malignant adult brain tumour, harbouring a bias towards hypomethylation at defined differentially methylated regions. This epigenetic signature correlates with an enrichment for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::479777cb9c250c9de7b5958bbefd73e3
https://doi.org/10.1101/2022.02.15.480525
https://doi.org/10.1101/2022.02.15.480525
Autor:
Jonathan Shapey, Yijing Xie, Elham Nabavi, Michael Ebner, Shakeel R. Saeed, Neil Kitchen, Neil Dorward, Joan Grieve, Andrew W. McEvoy, Anna Miserocchi, Patrick Grover, Robert Bradford, Yau‐Mun Lim, Sebastien Ourselin, Sebastian Brandner, Zane Jaunmuktane, Tom Vercauteren
Publikováno v:
Shapey, J, Xie, Y, Nabavi, E, Ebner, M, Saeed, S R, Kitchen, N, Dorward, N, Grieve, J, McEvoy, A W, Miserocchi, A, Grover, P, Bradford, R, Lim, Y-M, Ourselin, S, Brandner, S, Jaunmuktane, Z & Vercauteren, T 2022, ' Optical properties of human brain and tumour tissue : An ex vivo study spanning the visible range to beyond the second near-infrared window ', Journal of biophotonics, vol. 15, no. 4, e202100072 . https://doi.org/10.1002/jbio.202100072
Neuro-oncology surgery would benefit from detailed intraoperative tissue characterization provided by noncontact, contrast-agent-free, noninvasive optical imaging methods. In-depth knowledge of target tissue optical properties across a wide-wavelengt
Autor:
Boot, James, Rosser, Gabriel, Kancheva, Dailya, Vinel, Claire, Yau Mun Lim, Pomella, Nicola, Xinyu Zhang, Guglielmi, Loredana, Sheer, Denise, Barnes, Michael, Brandner, Sebastian, Nelander, Sven, Movahedi, Kiavash, Marino, Silvia
Publikováno v:
eLife; 11/22/2022, p1-33, 33p