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The type of stress matters: repeated injection and permanent social isolation stress in male mice have a differential effect on anxiety- and depressive-like behaviours, and associated biological alterations

Autor: Patricia A. Zunszain, Thomas Law, Yau M Lim, Martin Egeland, Abdul Hye, Sandrine Thuret, Carmine M. Pariante, Cathy Fernandes, Paola Eiben, Ksenia Musaelyan, Andrea Du Preez, Diletta Onorato

Publikováno v: Translational Psychiatry, Vol 10, Iss 1, Pp 1-17 (2020)
Translational Psychiatry

Chronic stress can alter the immune system, adult hippocampal neurogenesis and induce anxiety- and depressive-like behaviour in rodents. However, previous studies have not discriminated between the effect(s) of different types of stress on these beha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfe93676254e0a02a37a064d26393610
https://doi.org/10.1038/s41398-020-01000-3

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Exosome-mediated RNAi of PAK4 prolongs survival of pancreatic cancer mouse model after loco-regional treatment

Autor: Khuloud T. Al-Jamal, Farid N. Faruqu, Yau M. Lim, Paul Lavender, Kee Y. Lim, Revadee Liam-or, Adam A. Walters, Claire M. Wells, Lizhou Xu, Julie Tzu-Wen Wang, David J. Fear

Publikováno v: Biomaterials. 264

With a dismal survival rate, pancreatic cancer (PC) remains one of the most aggressive and devastating malignancies, predominantly due to the absence of a valid biomarker for diagnosis and limited therapeutic options for advanced diseases. Exosomes (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef098dde5cc052f81ef29496443c30c5
https://pubmed.ncbi.nlm.nih.gov/32977209

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PPARγ-coactivator-1α gene transfer reduces neuronal loss and amyloid-β generation by reducing β-secretase in an Alzheimer’s disease model

Autor: Magdalena Sastre, Laura Lombardero, Nicholas D. Mazarakis, Nazanin Mirzaei, Katrin Blondrath, Elaine E. Irvine, Yau M. Lim, Amy M. Birch, Ioanna Eleftheriadou, Loukia Katsouri

Current therapies for Alzheimer’s disease (AD) are symptomatic and do not target the underlying Aβ pathology and other important hallmarks including neuronal loss. PPARγ-coactivator-1α (PGC-1α) is a cofactor for transcription factors including

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b365654754431f32137ce3a2fb9a94c9
http://hdl.handle.net/10044/1/58722

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