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Cognitive and Disease-Modifying Effects of 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibition in Male Tg2576 Mice, a Model of Alzheimer's Disease

Autor: Sooy, Karen, Noble, June, McBride, Andrew, Binnie, Margaret, Yau, Joyce L. W., Seckl, Jonathan R., Walker, Brian R., Webster, Scott P.

Publikováno v: Endocrinology
Sooy, K, Noble, J, McBride, A, Binnie, M, Yau, J L W, Seckl, J R, Walker, B R & Webster, S P 2015, ' Cognitive and disease-modifying effects of 11ß-hydroxysteroid dehydrogenase type 1 inhibition in male Tg2576 mice, a model of Alzheimer's disease ', Endocrinology . https://doi.org/10.1210/en.2015-1395

Chronic exposure to elevated levels of glucocorticoids has been linked to age-related cognitive decline and may play a role in Alzheimer's disease. In the brain, 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) amplifies intracellular glucocortic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::16c04319bd8a86aa19b59cb4708de24b
http://europepmc.org/articles/PMC4655221

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Central administration of a cytochrome P450-7 alpha product 7 alpha-hydroxypregnenolone improves spatial memory retention in cognitively impaired aged rats

Autor: Yau, Joyce L. W., Noble, June, Graham, Mags, Seckl, Jonathan R.

Publikováno v: Yau, J L W, Noble, J, Graham, M & Seckl, J R 2006, ' Central administration of a cytochrome P450-7 alpha product 7 alpha-hydroxypregnenolone improves spatial memory retention in cognitively impaired aged rats ', Journal of Neuroscience, vol. 26, no. 43, pp. 11034-11040 . https://doi.org/10.1523/JNEUROSCI.3189-06-2006

Pregnenolone ( PREG) and dehydroepiandrosterone ( DHEA) have been reported to improve memory in aged rodents. In brain, these neurosteroids are transformed predominantly into 7 alpha-hydroxylated metabolites by the cytochrome P450-7B1 (CYP7B). The bi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3094::2452f29c98a43e2dc0a652542a5c5bd1
https://www.pure.ed.ac.uk/ws/files/8297224/Central_administration_of_a_cytochrome_P450_7_alpha_product_7_alpha_hydroxypregnenolone_improves_spatial_memory_retention_in_cognitively_impaired_aged_rats.pdf

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