Zobrazeno 1 - 10
of 228
pro vyhledávání: '"Yatrik M. Shah"'
Autor:
Yingying Yu, Yunxing Su, Sisi Yang, Yutong Liu, Zhiting Lin, Nupur K. Das, Qian Wu, Jiahui Zhou, Shumin Sun, Xiaopeng Li, Wuyang Yue, Yatrik M. Shah, Junxia Min, Fudi Wang
Publikováno v:
Advanced Science, Vol 11, Iss 12, Pp n/a-n/a (2024)
Abstract In clinics, hepcidin levels are elevated in various anemia‐related conditions, particularly in iron‐refractory anemia and in high inflammatory states that suppress iron absorption, which remains an urgent unmet medical need. To identify
Externí odkaz:
https://doaj.org/article/642ca73066054ea5b33a260633356e57
Autor:
Hidehiko Takabayashi, Tuo Ji, Lei Peng, Xuan Li, Masahiko Shinohara, Maria Mao, Kathryn A. Eaton, Yatrik M. Shah, Andrea Todisco
Publikováno v:
Gastro Hep Advances, Vol 2, Iss 2, Pp 221-231 (2023)
Background and Aims: Loss of bone morphogenetic protein (BMP) signaling in the stomach, achieved by transgenic expression of the BMP inhibitor noggin (H+/K+-Nog mice), causes parietal cell (PC) loss, spasmolytic polypeptide-expressing metaplasia, a m
Externí odkaz:
https://doaj.org/article/39a3d87912434c4b9bf691ec77dd319b
Autor:
Madathilparambil V. Suresh, George Yalamanchili, Tejeshwar C. Rao, Sinan Aktay, Alex Kralovich, Yatrik M. Shah, Krishnan Raghavendran
Publikováno v:
FASEB BioAdvances, Vol 4, Iss 5, Pp 309-328 (2022)
Abstract Aspiration‐induced lung injury is a common grievance encountered in the intensive care unit (ICU). It is a significant risk factor for improving ventilator‐associated pneumonia (VAP) and acute respiratory distress syndrome (ARDS). Hypoxi
Externí odkaz:
https://doaj.org/article/8da36eb0d527440a9cbb87ee412ffd5c
Autor:
Raja Gopal Reddy Mooli, Dhanunjay Mukhi, Anil K. Pasupulati, Simon S. Evers, Ian J. Sipula, Michael Jurczak, Randy J. Seeley, Yatrik M. Shah, Sadeesh K. Ramakrishnan
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 4, Pp 1057-1072 (2022)
Background & Aims: Compelling evidence shows that glucagon-like peptide-1 (GLP-1) has a profound effect in restoring normoglycemia in type 2 diabetic patients by increasing pancreatic insulin secretion. Although L-cells are the primary source of circ
Externí odkaz:
https://doaj.org/article/02b6ec9b78e94fa7a0450ec4181773fa
Autor:
Xiao Zhong, Zhiguo Zhang, Hong Shen, Yi Xiong, Yatrik M. Shah, Yong Liu, Xue‐Gong Fan, Liangyou Rui
Publikováno v:
Hepatology Communications, Vol 5, Iss 10, Pp 1704-1720 (2021)
Drug‐induced hepatotoxicity limits development of new effective medications. Drugs and numerous endogenous/exogenous agents are metabolized/detoxified by hepatocytes, during which reactive oxygen species (ROS) are generated as a by‐product. ROS h
Externí odkaz:
https://doaj.org/article/ab8559975f474835b9f621ec3bf225da
Autor:
Daniel M. Kremer, Barbara S. Nelson, Lin Lin, Emily L. Yarosz, Christopher J. Halbrook, Samuel A. Kerk, Peter Sajjakulnukit, Amy Myers, Galloway Thurston, Sean W. Hou, Eileen S. Carpenter, Anthony C. Andren, Zeribe C. Nwosu, Nicholas Cusmano, Stephanie Wisner, Nneka E. Mbah, Mengrou Shan, Nupur K. Das, Brian Magnuson, Andrew C. Little, Milan R. Savani, Johanna Ramos, Tina Gao, Stephen A. Sastra, Carmine F. Palermo, Michael A. Badgley, Li Zhang, John M. Asara, Samuel K. McBrayer, Marina Pasca di Magliano, Howard C. Crawford, Yatrik M. Shah, Kenneth P. Olive, Costas A. Lyssiotis
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
The aspartate aminotransaminase GOT1 is important for maintaining redox balance. Here, the authors show that inhibition of GOT1 in pancreatic cancer cells leads to cell death via ferroptosis.
Externí odkaz:
https://doaj.org/article/ed8c3b2903a54147ade49ed6c779e8e5
Autor:
Raja Gopal Reddy Mooli, Jessica Rodriguez, Shogo Takahashi, Sumeet Solanki, Frank J. Gonzalez, Sadeesh K. Ramakrishnan, Yatrik M. Shah
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 2, Pp 585-597 (2021)
Background & Aims: Fatty liver or nonalcoholic fatty liver disease (NAFLD) is the most common liver disease associated with comorbidities such as insulin resistance and cardiovascular and metabolic diseases. Chronic activation of hypoxic signaling, i
Externí odkaz:
https://doaj.org/article/ddbf79f26014419cb7dcf2170ec703f9
Publikováno v:
STAR Protocols, Vol 3, Iss 2, Pp 101311- (2022)
Summary: Metabolites are crucial for bidirectional communication between host and microbiome. We describe a protocol for the isolation of organic and aqueous metabolites from mucosal scrapes and feces from mouse and human samples. Although some of th
Externí odkaz:
https://doaj.org/article/c621b8662f3d410ebc38202426008bfc
Autor:
Yikai Shao, Simon S. Evers, Jae Hoon Shin, Sadeesh K. Ramakrishnan, Nadejda Bozadjieva-Kramer, Qiyuan Yao, Yatrik M. Shah, Darleen A. Sandoval, Randy J. Seeley
Publikováno v:
Molecular Metabolism, Vol 57, Iss , Pp 101432- (2022)
Objective: Vertical Sleeve Gastrectomy (VSG) is one of the most efficacious treatments for obesity and its comorbidities. Although a range of evidence suggests that alterations of the microbiota in the distal gut following VSG are pivotal to these me
Externí odkaz:
https://doaj.org/article/831fd8d516454b6b8a5e46bb1c32d9d3
Autor:
Samantha N. Devenport, Rashi Singhal, Megan D. Radyk, Joseph G. Taranto, Samuel A. Kerk, Brandon Chen, Joshua W. Goyert, Chesta Jain, Nupur K. Das, Katherine Oravecz-Wilson, Li Zhang, Joel K. Greenson, Y. Eugene Chen, Scott A. Soleimanpour, Pavan Reddy, Costas A. Lyssiotis, Yatrik M. Shah
Publikováno v:
JCI Insight, Vol 6, Iss 14 (2021)
Cancer cells reprogram cellular metabolism to maintain adequate nutrient pools to sustain proliferation. Moreover, autophagy is a regulated mechanism to break down dysfunctional cellular components and recycle cellular nutrients. However, the require
Externí odkaz:
https://doaj.org/article/87b33972a4d74baabccd55a30a6b5585