Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Yating Chong"'
Autor:
Baohuan Cai, Yun Liu, Yating Chong, Stephanie Fay Mori, Atsuko Matsunaga, Hualei Zhang, Xuexiu Fang, Chang-Sheng Chang, John K. Cowell, Tianxiang Hu
Publikováno v:
Molecular Cancer, Vol 21, Iss 1, Pp 1-20 (2022)
Abstract Background Myeloid and lymphoid malignancies associated with chimeric FGFR1 kinases are the hallmark of stem cell leukemia and lymphoma syndrome (SCLL). In all cases, FGFR1 kinase is constitutively phosphoactivated as a result of chromosome
Externí odkaz:
https://doaj.org/article/9ca7aaa5903b4c698f23b19d81161752
Autor:
Baohuan Cai, Yun Liu, Yating Chong, Hualei Zhang, Atsuko Matsunaga, Xuexiu Fang, Rafal Pacholczyk, Gang Zhou, John K. Cowell, Tianxiang Hu
Publikováno v:
Molecular Cancer, Vol 20, Iss 1, Pp 1-20 (2021)
Abstract Background Stem Cell leukemia/lymphoma syndrome (SCLL) presents as a myeloproliferative disease which can progress to acute myeloid leukemia and is associated with the coincident development of B-cell and T-cell lymphomas. SCLL is driven by
Externí odkaz:
https://doaj.org/article/e0787b24be88424187af7b0bd5f1654d
Autor:
Hualei Zhang, Baohuan Cai, Yun Liu, Yating Chong, Atsuko Matsunaga, Stephanie Fay Mori, Xuexiu Fang, Eiko Kitamura, Chang-Sheng Chang, Ping Wang, John K Cowell, Tianxiang Hu
Publikováno v:
Haematologica, Vol 108, Iss 1 (2022)
The Philadelphia 9;22 chromosome translocation has two common isoforms that are preferentially associated with distinct subtypes of leukemia. The p210 variant is the hallmark of chronic myeloid leukemia (CML) whereas p190 is frequently associated wit
Externí odkaz:
https://doaj.org/article/4da9e3737ecd4f4ab426c69b3fb1b757
Publikováno v:
Haematologica, Vol 105, Iss 2 (2020)
Externí odkaz:
https://doaj.org/article/78ad0325a3e541ae99bcc4d9306f2f54
Autor:
John K Cowell, Chang-Sheng Chang, Natasha M. Savage, Mingqiang Ren, Haiyan Qin, Sumin Lu, Yating Chong, Tianxiang Hu
Engraftment of BBC2 cells in which RhoA is knocked down leads to splenomegaly (A) and increased lymph node size.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20e12306a41def6cb5a9d0057bb1dcfd
https://doi.org/10.1158/0008-5472.22421186
https://doi.org/10.1158/0008-5472.22421186
Autor:
John K Cowell, Chang-Sheng Chang, Natasha M. Savage, Mingqiang Ren, Haiyan Qin, Sumin Lu, Yating Chong, Tianxiang Hu
Transformation of hematopoietic stem cells by the BCR–FGFR1 fusion kinase found in a variant of stem cell leukemia/lymphoma (SCLL) syndrome leads to development of B-lymphomas in syngeneic mice and humans. In this study, we show that the relatively
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c45f92cb81d148fe4190084912bab1af
https://doi.org/10.1158/0008-5472.c.6510857.v1
https://doi.org/10.1158/0008-5472.c.6510857.v1
Autor:
John K Cowell, Chang-Sheng Chang, Natasha M. Savage, Mingqiang Ren, Haiyan Qin, Sumin Lu, Yating Chong, Tianxiang Hu
Representative images of the peripheral blood, liver and spleen from mice transplanted with bone marrow transduced with either the empty vector (MIG), the full length BCR-FGFR1 chimeric kinase or the BCR-FGFR1 construct with deletion of the BCR GEF d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::367a821669c9365bfb13b7812f045afe
https://doi.org/10.1158/0008-5472.22421201.v1
https://doi.org/10.1158/0008-5472.22421201.v1
Autor:
John K. Cowell, LesleyAnn Hawthorn, Chang-Sheng Chang, Eiko Kitamura, Jeane Silva, Haiyan Qin, Rebecca Wang, Sumin Lu, Yating Chong, Tianxiang Hu
The development of myeloid and lymphoid neoplasms related to overexpression of FGFR1 kinases as a result of chromosome translocations depends on the promotion of a stem cell phenotype, suppression of terminal differentiation, and resistance to apopto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c0e198ede7e5af92cee0f35b0f0cd5d
https://doi.org/10.1158/0008-5472.c.6510396.v1
https://doi.org/10.1158/0008-5472.c.6510396.v1
Autor:
John K Cowell, Chang-Sheng Chang, Natasha M. Savage, Mingqiang Ren, Haiyan Qin, Sumin Lu, Yating Chong, Tianxiang Hu
Representative flow cytometric analysis of GFP+ cells from the spleens of mice transplanted with cells transduced with either the empty vector (MIG), full length BCR-FGFR1 chimeric kinase or GEF deletion construct.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::317463bb56858f2636dcbee296bd98e6
https://doi.org/10.1158/0008-5472.22421198.v1
https://doi.org/10.1158/0008-5472.22421198.v1
Autor:
John K. Cowell, LesleyAnn Hawthorn, Chang-Sheng Chang, Eiko Kitamura, Jeane Silva, Haiyan Qin, Rebecca Wang, Sumin Lu, Yating Chong, Tianxiang Hu
Supplemental Figure 1 defining the immunophenotypes of SCLL cell lines used in this study. Supplemental figure 2 describes normalized miR339 and FGFR1 expression levels in normal B-cells and CLL compared with ALL. Supplemental figure 3 describes the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::081ad453eea919eb5994940dc7e734d7
https://doi.org/10.1158/0008-5472.22419501
https://doi.org/10.1158/0008-5472.22419501