Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Yasuyuki Sera"'
Autor:
Yuichiro Nakata, Shion Nagasawa, Yasuyuki Sera, Norimasa Yamasaki, Akinori Kanai, Kohei Kobatake, Takeshi Ueda, Miho Koizumi, Ichiro Manabe, Osamu Kaminuma, Hiroaki Honda
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract The genome is constantly exposed to DNA damage from endogenous and exogenous sources. Fine modulation of DNA repair, chromatin remodeling, and transcription factors is necessary for protecting genome integrity, but the precise mechanisms are
Externí odkaz:
https://doaj.org/article/82b7b77af190493ea855123415683089
Autor:
Hiroaki Honda, Akio Matsubara, Peter C. Black, Shigeo Horie, Wataru Yasui, Zen-ichiro Honda, Tatsuo Ichinohe, Osamu Kaminuma, Yusuke Sotomaru, Toshiya Inaba, Yoshihiko Miyakawa, Miho Koizumi, Tetsutaro Hayashi, Yasuyuki Sera, Kazuhiro Sentani, Akinori Kanai, Takeshi Ueda, Norimasa Yamasaki, Yuichiro Nakata, Ken-ichiro Ikeda, Kohei Kobatake
Supplementary Information: Tables S1, S2, S3, S4 (gene set enrichment analyses); Figures S1, S2, S3, S4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82ea0cbe924dac531b90a6dc17350c9c
https://doi.org/10.1158/1078-0432.22479381
https://doi.org/10.1158/1078-0432.22479381
Autor:
Hiroaki Honda, Akio Matsubara, Peter C. Black, Shigeo Horie, Wataru Yasui, Zen-ichiro Honda, Tatsuo Ichinohe, Osamu Kaminuma, Yusuke Sotomaru, Toshiya Inaba, Yoshihiko Miyakawa, Miho Koizumi, Tetsutaro Hayashi, Yasuyuki Sera, Kazuhiro Sentani, Akinori Kanai, Takeshi Ueda, Norimasa Yamasaki, Yuichiro Nakata, Ken-ichiro Ikeda, Kohei Kobatake
Purpose:Epigenetic deregulation is deeply implicated in the pathogenesis of bladder cancer. KDM6A (Lysine (K)-specific demethylase 6A) is a histone modifier frequently mutated in bladder cancer. However, the molecular mechanisms of how KDM6A deficien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::019821b37865f0b92e74101adfa8de18
https://doi.org/10.1158/1078-0432.c.6530205.v1
https://doi.org/10.1158/1078-0432.c.6530205.v1
Autor:
Miho Koizumi, Hikaru Eto, Mai Saeki, Masahide Seki, Tsuyoshi Fukushima, Shoichiro Mukai, Hisamitsu Ide, Yasuyuki Sera, Masayuki Iwasaki, Yutaka Suzuki, Atsushi Tohei, Yusuke Kishi, Hiroaki Honda
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental BiologyREFERENCES. 36(12)
Recent studies have demonstrated that epigenetic modifications are deeply involved in neurogenesis; however, the precise mechanisms remain largely unknown. To determine the role of UTX (also known as KDM6A), a demethylase of histone H3K27, in neural
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0803febfe3c3b716b985f1df18cc66d
https://pubmed.ncbi.nlm.nih.gov/36607616
https://pubmed.ncbi.nlm.nih.gov/36607616
Autor:
Keiyo Takubo, Phyo Wai Htun, Takeshi Ueda, Yasuyuki Sera, Masayuki Iwasaki, Miho Koizumi, Kohei Shiroshita, Hiroshi Kobayashi, Miho Haraguchi, Shintaro Watanuki, Zen-ichiro Honda, Norimasa Yamasaki, Ayako Nakamura-Ishizu, Fumio Arai, Noboru Motoyama, Tomohisa Hatta, Tohru Natsume, Toshio Suda, Hiroaki Honda
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 8/8/2023, Vol. 120 Issue 32, p1-10, 39p
Autor:
Kenichiro Ikeda, Toshiya Inaba, Yasuyuki Sera, Takeshi Ueda, Miho Koizumi, Kazuhiro Sentani, Wataru Yasui, Shigeo Horie, Hiroaki Honda, Yoshihiko Miyakawa, Norimasa Yamasaki, Yusuke Sotomaru, Akio Matsubara, Tatsuo Ichinohe, Kohei Kobatake, Peter C. Black, Osamu Kaminuma, Zen-ichiro Honda, Akinori Kanai, Yuichiro Nakata, Tetsutaro Hayashi
Publikováno v:
Clinical Cancer Research. 26:2065-2079
Purpose: Epigenetic deregulation is deeply implicated in the pathogenesis of bladder cancer. KDM6A (Lysine (K)-specific demethylase 6A) is a histone modifier frequently mutated in bladder cancer. However, the molecular mechanisms of how KDM6A deficie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::864925ae5bc2a62cfe5bc6c219893421
https://doi.org/10.1158/1078-0432.ccr-19-2230
https://doi.org/10.1158/1078-0432.ccr-19-2230
Autor:
Kimihito Cojin Kawabata, Hiroaki Honda, Makoto Saika, Takeshi Fujino, Norimasa Yamasaki, Hwei-Fang Tien, Yasunori Ota, Yasuyuki Sera, Akinori Kanai, Toshio Kitamura, Sayuri Horikawa, Daichi Inoue, Alessandro Pastore, Hsin-An Hou, Shuhei Asada, Y Hayashi, Reina Nagase, Susumu Goyama, Reina Takeda, Omar Abdel-Wahab
Publikováno v:
The Journal of Experimental Medicine
Nagase and Inoue et al. generated a novel Asxl1 mutant mouse model to mimic clonal hematopoiesis and myelodysplastic syndromes caused by ASXL1 mutations and elucidated the effects of mutant versus wild-type ASXL1 on hematopoiesis, gene expression, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05bccb4773e4eb3d2c75a628de24b5b9
http://europepmc.org/articles/PMC5987913
http://europepmc.org/articles/PMC5987913
Autor:
Zen-ichiro Honda, Takeshi Ueda, Toshio Suda, Akinori Kanai, Kenichiro Ikeda, Keiyo Takubo, Hideaki Oda, Seishi Ogawa, Toshiya Inaba, Yasuhiro Ebihara, Yasuyuki Sera, Yuichiro Nakata, Kohichiro Tsuji, Masashi Sanada, Akiko Nagamachi, Linda Wolff, Hiroaki Honda, Norimasa Yamasaki
Publikováno v:
Blood. 129:2148-2160
Chronic myelomonocytic leukemia (CMML) is a hematological malignancy characterized by uncontrolled proliferation of dysplastic myelomonocytes and frequent progression to acute myeloid leukemia (AML). We identified mutations in the Cbl gene, which enc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebcc8f8bb9429d6e8cc95b72d59dc024
https://doi.org/10.1182/blood-2016-06-724658
https://doi.org/10.1182/blood-2016-06-724658
Autor:
Kenichiro Ikeda, Hideaki Oda, Miho Koizumi, Toshiya Inaba, Akiko Nagamachi, Kohei Kobatake, Takeshi Ueda, Hiroshi Kobayashi, Zen-ichiro Honda, Keiyo Takubo, Linda Wolff, Yusuke Sotomaru, Toshio Suda, Tatsuo Ichinohe, Masayuki Iwasaki, Yasuyuki Sera, Yuichiro Nakata, Atsushi Iwama, Shuhei Koide, Akinori Kanai, Hiroaki Honda, Norimasa Yamasaki, Yoshihiko Miyakawa
Publikováno v:
Blood
Epigenetic regulation is essential for the maintenance of the hematopoietic system, and its deregulation is implicated in hematopoietic disorders. In this study, UTX, a demethylase for lysine 27 on histone H3 (H3K27) and a component of COMPASS-like a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b3cd691d8564e4d37a8e23438d6cba1
https://pubmed.ncbi.nlm.nih.gov/33174606
https://pubmed.ncbi.nlm.nih.gov/33174606
Autor:
Yasuyuki Sera, Takeshi Inukai, Hideaki Oda, Akiko Nagamachi, Toshiya Inaba, Linda Wolff, Hiroaki Honda, Norimasa Yamasaki
Publikováno v:
Cancer Science
E2A-PBX1 is a chimeric gene product detected in t(1;19)-bearing acute lymphoblastic leukemia (ALL) with B-cell lineage. To investigate the leukemogenic process, we generated conditional knock-in (cKI) mice for E2A-PBX1, in which E2A-PBX1 is inducibly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a09f8e9824585fe79d8367a64f8c8aff
https://doi.org/10.1111/cas.12945
https://doi.org/10.1111/cas.12945