Zobrazeno 1 - 10
of 156
pro vyhledávání: '"Yasuyuki Morishita"'
Autor:
Kei Takahashi, Ko Abe, Shimpei I. Kubota, Noriaki Fukatsu, Yasuyuki Morishita, Yasuhiro Yoshimatsu, Satoshi Hirakawa, Yoshiaki Kubota, Tetsuro Watabe, Shogo Ehata, Hiroki R. Ueda, Teppei Shimamura, Kohei Miyazono
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Understanding blood and lymphatic vasculature networks is currently limited by existing imaging systems and quantification methods. Here the authors use the tissue clearing method CUBIC to generate 3D images, machine learning to capture the signals,
Externí odkaz:
https://doaj.org/article/100286a83f0b4110a65d72ca7004c10b
Autor:
Kei Takahashi, Shogo Ehata, Kensuke Miyauchi, Yasuyuki Morishita, Keiji Miyazawa, Kohei Miyazono
Publikováno v:
Molecular Oncology, Vol 15, Iss 1, Pp 151-166 (2021)
Pancreatic cancer is one of the cancers with the poorest prognosis, with a 5‐year survival rate of approximately 5–10%. Thus, it is urgent to identify molecular targets for the treatment of pancreatic cancer. Using serial transplantations in a mo
Externí odkaz:
https://doaj.org/article/091676d157b44a0986c15194fcfdf41a
Autor:
Takayuki Ozawa, Masato Morikawa, Yasuyuki Morishita, Kazuki Ogikubo, Fumiko Itoh, Daizo Koinuma, Per-Åke Nygren, Kohei Miyazono
Publikováno v:
iScience, Vol 24, Iss 5, Pp 102488- (2021)
Summary: Targeting the signaling pathway of growth differentiation factor 8 (GDF8), also known as myostatin, has been regarded as a promising strategy to increase muscle mass in the elderly and in patients. Accumulating evidence in animal models and
Externí odkaz:
https://doaj.org/article/2cfda72b13db4533878d932413d7d8cf
Autor:
Akihiro Katsura, Yusuke Tamura, Satoshi Hokari, Mayumi Harada, Masato Morikawa, Tsubasa Sakurai, Kei Takahashi, Anna Mizutani, Jun Nishida, Yuichiro Yokoyama, Yasuyuki Morishita, Takashi Murakami, Shogo Ehata, Kohei Miyazono, Daizo Koinuma
Publikováno v:
Molecular Oncology, Vol 11, Iss 9, Pp 1241-1262 (2017)
Zinc finger E‐box binding protein 1 (ZEB1) and ZEB2 induce epithelial‐mesenchymal transition (EMT) and enhance cancer progression. However, the global view of transcriptional regulation by ZEB1 and ZEB2 is yet to be elucidated. Here, we identifie
Externí odkaz:
https://doaj.org/article/c67256e5806648d6ad33a8fcdb477d71
Autor:
Shimpei I. Kubota, Kei Takahashi, Jun Nishida, Yasuyuki Morishita, Shogo Ehata, Kazuki Tainaka, Kohei Miyazono, Hiroki R. Ueda
Publikováno v:
Cell Reports, Vol 20, Iss 1, Pp 236-250 (2017)
Stochastic and proliferative events initiated from a single cell can disrupt homeostatic balance and lead to fatal disease processes such as cancer metastasis. To overcome metastasis, it is necessary to detect and quantify sparsely distributed metast
Externí odkaz:
https://doaj.org/article/274b934335aa4e7ab758797f0734ba2a
Autor:
Munetoshi Hinata, Akiko Kunita, Hiroyuki Abe, Yasuyuki Morishita, Kei Sakuma, Hiroharu Yamashita, Yasuyuki Seto, Tetsuo Ushiku, Masashi Fukayama
Publikováno v:
Microorganisms, Vol 8, Iss 11, p 1776 (2020)
The Epstein-Barr virus (EBV)-associated gastric carcinoma (EBVaGC) is characterized by the infiltration of lymphocytes and a unique tumor microenvironment. Exosomes from cancer cells are essential for intercellular communication. The aims of this stu
Externí odkaz:
https://doaj.org/article/fd4c74f1db00481cb80c913f5c21ffe0
Autor:
Koji Nagaoka, Akihiro Hosoi, Tamaki Iino, Yasuyuki Morishita, Hirokazu Matsushita, Kazuhiro Kakimi
Publikováno v:
OncoImmunology, Vol 7, Iss 3 (2018)
The success of immune checkpoint blockade has unequivocally demonstrated that anti-tumor immunity plays a pivotal role in cancer therapy. Because endogenous tumor-specific T-cell responsiveness is essential for the success of checkpoint blockade, com
Externí odkaz:
https://doaj.org/article/d4c6bf9dcedb4455aa025a93e63ad320
Autor:
Hiroki Takai, Koji Masuda, Tomohiro Sato, Yuriko Sakaguchi, Takeo Suzuki, Tsutomu Suzuki, Ryo Koyama-Nasu, Yukiko Nasu-Nishimura, Yuki Katou, Haruo Ogawa, Yasuyuki Morishita, Hiroko Kozuka-Hata, Masaaki Oyama, Tomoki Todo, Yasushi Ino, Akitake Mukasa, Nobuhito Saito, Chikashi Toyoshima, Katsuhiko Shirahige, Tetsu Akiyama
Publikováno v:
Cell Reports, Vol 9, Iss 1, Pp 48-60 (2014)
Summary: The development of cancer is driven not only by genetic mutations but also by epigenetic alterations. Here, we show that TET1-mediated production of 5-hydroxymethylcytosine (5hmC) is required for the tumorigenicity of glioblastoma cells. Fur
Externí odkaz:
https://doaj.org/article/6e167373836c4249903547f389fae70e
Autor:
Akira Saito, Hiroshi I. Suzuki, Masafumi Horie, Mitsuhiro Ohshima, Yasuyuki Morishita, Yoshimitsu Abiko, Takahide Nagase
Publikováno v:
PLoS ONE, Vol 9, Iss 1 (2014)
Externí odkaz:
https://doaj.org/article/5dc144f9d67f4ee1922fedf9e8afa079
Autor:
Akira Saito, Hiroshi I Suzuki, Masafumi Horie, Mitsuhiro Ohshima, Yasuyuki Morishita, Yoshimitsu Abiko, Takahide Nagase
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e56587 (2013)
EMT (epithelial-mesenchymal transition) is crucial for cancer cells to acquire invasive phenotypes. In A549 lung adenocarcinoma cells, TGF-β elicited EMT in Smad-dependent manner and TNF-α accelerated this process, as confirmed by cell morphology,
Externí odkaz:
https://doaj.org/article/1ff946eeaf684332961a18e952cb0465