Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Yasuyuki Mizuki"'
Autor:
Sadao Komemushi, Yasuyuki Mizuki, Hidetada Sasaki, Hiroyuki Arai, Michiko Kano, Masatoshi Itoh, Masaaki Tagawa, Takehiko Watanabe, Toshihiko Fujii, Michiaki Matsuda, Makoto Higuchi, Kazuhiko Yanai, Nobuyuki Okamura
Publikováno v:
British Journal of Clinical Pharmacology. 53:296-304
Aims It has been widely recognized that classical antihistamines induce sedation as an adverse effect, while second-generation antihistamines have few if any sedative effects. In order to evaluate the sedative properties of ebastine, a second-generat
Autor:
Michiaki Matsuda, Masatoshi Itoh, Hiroyuki Arai, Michiko Kano, Tatsuo Ido, Ren Iwata, Hidetada Sasaki, Kazuhiko Yanai, Nobuyuki Okamura, Toshihiko Fujii, Masaaki Tagawa, Yasuyuki Mizuki, Sadao Komemushi, Makoto Higuchi, Takehiko Watanabe
Publikováno v:
British Journal of Clinical Pharmacology. 52:501-509
Aims Sedation induced by antihistamines is widely recognized to be caused by their penetration through the blood-brain-barrier and the consequent occupation of brain histamine H 1 -receptors. We previously studied the mechanism of sedation caused by
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 757:173-179
Ebastine (CAS 90729-43-4) is an antiallergic agent which selectively and potently blocks histamine H1-receptors in vivo. A simple and sensitive high-performance liquid chromatography (HPLC) method is described for the simultaneous determination of eb
Publikováno v:
Journal of Antimicrobial Chemotherapy. 37:41-55
Fluoroquinolone derivatives interact with methylxanthines (theophylline, caffeine) and metallic ion-containing drugs to different degrees. The rat appears to be a suitable model for predicting such interactions in man. It has been possible to determi
Publikováno v:
Drug metabolism and pharmacokinetics. 26(3)
The oral bioavailability of some drugs is markedly lower in cynomolgus monkeys than in humans. One of the reasons for the low bioavailability in cynomolgus monkeys may be the higher metabolic activity of intestinal CYP3A; however, the species differe
Publikováno v:
Drug metabolism and pharmacokinetics. 25(4)
Using physiologically-based pharmacokinetic model simulations with the assumption that elimination of inactivator is not altered by mechanism-based inactivation (MBI) of the target enzyme, we examined at what concentrations the influence of MBI could
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 38(11)
To select high bioavailability compounds, it is necessary to predict the first-pass metabolism in the intestine. However, in vitro-in vivo predictions of the intestinal metabolism have proven both challenging and less definitive. The purpose of this
Publikováno v:
Drug Metabolism and Pharmacokinetics. 6:67-72
The effect of sparfloxacin on the theophylline pharmacokinetics was investigated in rats.1. The plasma levels and pharmacokinetic parameters of theophylline after a single oral dose (15mg/kg) in rats treated orally with sparfloxacin (100 mg/kg, 3 tim
Publikováno v:
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 776(2)
A convenient liquid chromatographic–single quadrupole mass spectrometric (LC–MS) method was developed and validated for the determination of chlorpheniramine maleate (INN name: chlorphenamine) in human plasma. The method had advantages of a singl
Autor:
Masafumi Yabuuchi, Isamu Nose, Tsugutaka Ito, Yasuyuki Mizuki, Katsuyoshi Nakatsuji, Yoshihide Kii
Publikováno v:
Pharmacologytoxicology. 89(2)
The purpose of this study was to examine the arrhythmogenic potential of 5-HT4 receptor agonists, cisapride and mosapride citrate (mosapride) in vivo. In anaesthetized rats, cisapride at intravenous infusion of 10 and 30 mg/kg/hr for 1 hr prolonged t