Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Yasuyuki Kirii"'
Autor:
Takashi Matsumoto, Yasuyuki Kirii, Masaaki Sawa, Takayoshi Kinoshita, Takuma Hashimoto, Yuri Sogabe
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:593-596
5Z-7-Oxozeaenol (5Z7O) is a covalent bonding inhibitor against the several protein kinases (e.g., ERK2 and TAK1) that possess a free cysteine at the gatekeeper-2 position. In addition to this cysteine, MAP2K7 has three other cysteine residues that ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcea0092ad3136d4df85b16622afb2ec
https://doi.org/10.1016/j.bmcl.2014.12.011
https://doi.org/10.1016/j.bmcl.2014.12.011
Publikováno v:
SLAS Discovery. 19:453-461
In evaluating kinase inhibitors, kinetic parameters such as association/dissociation rate constants are valuable information, as are equilibrium parameters K D and IC 50 values. Surface plasmon resonance (SPR) is a powerful technique to investigate t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::672ed75f298eb9e449abb3b93828c5f6
https://doi.org/10.1177/1087057113506051
https://doi.org/10.1177/1087057113506051
Autor:
Kensaku Akita, Hiroshi Ohmoto, Eiji Nishiwaki, Koichi Yokota, Masaki Gouda, Yugo Narumi, Yasuyuki Kirii, Daisuke Kitagawa
Publikováno v:
Genes to Cells. 18:110-122
The specificities of nine approved tyrosine kinase inhibitors (imatinib, dasatinib, nilotinib, gefitinib, erlotinib, lapatinib, sorafenib, sunitinib, and pazopanib) were determined by activity-based kinase profiling using a large panel of human recom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f853d18fadece6055167ba1af93b6136
https://doi.org/10.1111/gtc.12022
https://doi.org/10.1111/gtc.12022
Autor:
Yuri Sogabe, Takuma Hashimoto, Yasuyuki Kirii, Takayoshi Kinoshita, Takashi Matsumoto, Masaaki Sawa
Publikováno v:
Biochemical and biophysical research communications. 473(2)
Mitogen-activated protein kinase kinase 7 (MAP2K7) is an indispensable kinase of the c-Jun N-terminal kinase signal cascade and is rigorously regulated via phosphorylation. To investigate the regulatory mechanism of the inactive non-phosphorylated st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96d4637984bc88d2c4a0fcefb60f97b6
https://pubmed.ncbi.nlm.nih.gov/26987717
https://pubmed.ncbi.nlm.nih.gov/26987717
Publikováno v:
Biochemical and Biophysical Research Communications. 425:195-200
Mitogen-activated protein kinase kinase 4 (MAP2K4) plays a crucial role in the stress-activated signal cascade and is enzymatically regulated by ligand or substrate binding, and/or post-translational modification. Crystal structures combined with sma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e22b5114d2992795dc2a2bfec98fc8f5
https://doi.org/10.1016/j.bbrc.2012.07.066
https://doi.org/10.1016/j.bbrc.2012.07.066
Autor:
Yasuyuki Kirii, Daisuke Kitagawa, Yugo Narumi, Masaki Gouda, Ikuo Fujii, Koichi Yokota, Naoyuki Sugiyama, Kensaku Akita, Yasushi Ishihama
Publikováno v:
Journal of Biochemistry. 151:47-55
It is known that some kinase inhibitors are sensitive to the phosphorylation state of the kinase, and therefore those compounds can discriminate between a phosphorylated and unphosphorylated protein. In this study, we prepared two colony stimulating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f8afe42e5d7a382d8239223c563dbd9
https://doi.org/10.1093/jb/mvr112
https://doi.org/10.1093/jb/mvr112
Autor:
Kensaku Hamada, Koichi Yokota, Takashi Matsumoto, Yasuyuki Kirii, Takayoshi Kinoshita, Toshiji Tada
Publikováno v:
Biochemical and Biophysical Research Communications. 400:369-373
MKK4 activates both JNKs and p38s. We determined the crystal structures of human non-phosphorylated MKK4 kinase domain (npMKK4) complexed with AMP-PNP (npMKK4/AMP) and a ternary complex of npMKK4, AMP-PNP and p38α peptide (npMKK4/AMP/p38). These cry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::588ed7f36647c365c44a849e48b301e3
https://doi.org/10.1016/j.bbrc.2010.08.071
https://doi.org/10.1016/j.bbrc.2010.08.071
Autor:
Yasuyuki Kirii, Ko Okumura, Tomomi Inoue, Kohichiro Yoshino, Yasuhiro Yoshikawa, Nobuhiko Kayagaki, Hideo Yagita, Hiroaki Shibata, Keiji Terao
Publikováno v:
Journal of Immunological Methods. 278:201-209
Fas ligand (FasL) cDNAs were cloned and sequenced from cynomolgus, rhesus, and pig-tailed monkeys. The 840-bp cDNAs were identical among these three species of monkeys except for one nucleotide. The deduced 280 amino acids were completely identical a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dae6a4f7bdca4025599b8b2d5754a5ba
https://doi.org/10.1016/s0022-1759(03)00187-x
https://doi.org/10.1016/s0022-1759(03)00187-x
Autor:
Yasuko Ito, Minoru Yamamoto, Masaaki Sawa, Yu Maeda, Tomomi Inoue, Etsuko Ishibushi, Ryoichi Hirayama, Eiji Nishiwaki, Yoshimasa Inoue, Kohichiro Yoshino, Yasuyuki Kirii, Kiriko Kurokawa, Tomohiro Miyasaka, Hirosato Kondo, Takao Kiyoi, Hiroshi Kumihara, Hiroshi Ohmoto
Publikováno v:
Journal of Medicinal Chemistry. 45:919-929
A series of phosphonamide-based hydroxamate derivatives were synthesized, and the inhibitory activities were evaluated against various metalloproteinases in order to clarify its selectivity profile. Among the four diastereomeric isomers resulting fro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79cda93ba742f3aff92e244d17d126da
https://doi.org/10.1021/jm0103211
https://doi.org/10.1021/jm0103211
Autor:
Yasuyuki Kirii, Toshihiko Matsukura
Publikováno v:
Virus Genes. 17:117-121
The complete nucleotide sequence of human papillomavirus type 67 (HPV 67) cloned from a vaginal intraepithelial neoplasia, has been determined. It consists of 7801 nucleotides with a GC content of 38.4% and exhibits similar genome organizations of ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::51b1e834ca5076f9ac552803d1232178
https://doi.org/10.1023/a:1008002905588
https://doi.org/10.1023/a:1008002905588