Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Yasuyuki Hosono"'
Autor:
Yingsong Lin, Masahiro Nakatochi, Yasuyuki Hosono, Hidemi Ito, Yoichiro Kamatani, Akihito Inoko, Hiromi Sakamoto, Fumie Kinoshita, Yumiko Kobayashi, Hiroshi Ishii, Masato Ozaka, Takashi Sasaki, Masato Matsuyama, Naoki Sasahira, Manabu Morimoto, Satoshi Kobayashi, Taito Fukushima, Makoto Ueno, Shinichi Ohkawa, Naoto Egawa, Sawako Kuruma, Mitsuru Mori, Haruhisa Nakao, Yasushi Adachi, Masumi Okuda, Takako Osaki, Shigeru Kamiya, Chaochen Wang, Kazuo Hara, Yasuhiro Shimizu, Tatsuo Miyamoto, Yuko Hayashi, Hiromichi Ebi, Tomohiro Kohmoto, Issei Imoto, Yumiko Kasugai, Yoshinori Murakami, Masato Akiyama, Kazuyoshi Ishigaki, Koichi Matsuda, Makoto Hirata, Kazuaki Shimada, Takuji Okusaka, Takahisa Kawaguchi, Meiko Takahashi, Yoshiyuki Watanabe, Kiyonori Kuriki, Aya Kadota, Rieko Okada, Haruo Mikami, Toshiro Takezaki, Sadao Suzuki, Taiki Yamaji, Motoki Iwasaki, Norie Sawada, Atsushi Goto, Kengo Kinoshita, Nobuo Fuse, Fumiki Katsuoka, Atsushi Shimizu, Satoshi S. Nishizuka, Kozo Tanno, Ken Suzuki, Yukinori Okada, Momoko Horikoshi, Toshimasa Yamauchi, Takashi Kadowaki, Herbert Yu, Jun Zhong, Laufey T. Amundadottir, Yuichiro Doki, Hideshi Ishii, Hidetoshi Eguchi, David Bogumil, Christopher A. Haiman, Loic Le Marchand, Masaki Mori, Harvey Risch, Veronica W. Setiawan, Shoichiro Tsugane, Kenji Wakai, Teruhiko Yoshida, Fumihiko Matsuda, Michiaki Kubo, Shogo Kikuchi, Keitaro Matsuo
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Previous genome-wide association studies have identified risk loci for pancreatic cancer but were centered on individuals of European ancestry. Here the authors identify GP2 gene variants associated with pancreatic cancer susceptibility in population
Externí odkaz:
https://doaj.org/article/0e3ece4078314ff691b9afbec5ed4300
Autor:
Genta Takemoto, Masaki Matsushita, Takaaki Okamoto, Toshinari Ito, Yuki Matsuura, Chieko Takashima, Toyofumi Fengshi Chen-Yoshikawa, Hiromichi Ebi, Shiro Imagama, Hiroshi Kitoh, Kinji Ohno, Yasuyuki Hosono
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2022)
Meclozine has been developed as an inhibitor of fibroblast growth factor receptor 3 (FGFR3) to treat achondroplasia (ACH). Extracellular signal regulated kinase (ERK) phosphorylation was attenuated by meclozine in FGF2-treated chondrocyte cell line,
Externí odkaz:
https://doaj.org/article/c34b8201d58b4d52b95eea27a34b8859
Autor:
Yashar S. Niknafs, Sumin Han, Teng Ma, Corey Speers, Chao Zhang, Kari Wilder-Romans, Matthew K. Iyer, Sethuramasundaram Pitchiaya, Rohit Malik, Yasuyuki Hosono, John R. Prensner, Anton Poliakov, Udit Singhal, Lanbo Xiao, Steven Kregel, Ronald F. Siebenaler, Shuang G. Zhao, Michael Uhl, Alexander Gawronski, Daniel F. Hayes, Lori J. Pierce, Xuhong Cao, Colin Collins, Rolf Backofen, Cenk S. Sahinalp, James M. Rae, Arul M. Chinnaiyan, Felix Y. Feng
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
LncRNAs have been associated with cancer. Here, the authors carry out a systematic review of lncRNAs in breast cancer and show that DSCAM-AS1is highly expressed in oestrogen receptor positive tumours and enhances cancer through an interaction with hn
Externí odkaz:
https://doaj.org/article/683cca27103c413a96704a7bec3d8d79
Autor:
Sunita Shankar, Sethuramasundaram Pitchiaya, Rohit Malik, Vishal Kothari, Yasuyuki Hosono, Anastasia K. Yocum, Harika Gundlapalli, Yasmine White, Ari Firestone, Xuhong Cao, Saravana M. Dhanasekaran, Jeanne A. Stuckey, Gideon Bollag, Kevin Shannon, Nils G. Walter, Chandan Kumar-Sinha, Arul M. Chinnaiyan
Publikováno v:
Cell Reports, Vol 14, Iss 6, Pp 1448-1461 (2016)
Oncogenic mutations in RAS provide a compelling yet intractable therapeutic target. Using co-immunoprecipitation mass spectrometry, we uncovered an interaction between RAS and Argonaute 2 (AGO2). Endogenously, RAS and AGO2 co-sediment and co-localize
Externí odkaz:
https://doaj.org/article/f133faf0e1bf409685a3407f3bf3ecbb
Autor:
Teppei Shimamura, Seiya Imoto, Yukako Shimada, Yasuyuki Hosono, Atsushi Niida, Masao Nagasaki, Rui Yamaguchi, Takashi Takahashi, Satoru Miyano
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e20804 (2011)
Patient-specific analysis of molecular networks is a promising strategy for making individual risk predictions and treatment decisions in cancer therapy. Although systems biology allows the gene network of a cell to be reconstructed from clinical gen
Externí odkaz:
https://doaj.org/article/41cbea41eb5541bfb03e9dae37705f44
Autor:
Mika Iwai, Taisuke Kajino, Masahiro Nakatochi, Kiyoshi Yanagisawa, Yasuyuki Hosono, Hisanori Isomura, Yukako Shimada, Motoshi Suzuki, Ayumu Taguchi, Takashi Takahashi
Publikováno v:
Oncogene. 42:364-373
Non-coding RNAs have an integral regulatory role in numerous functions related to lung cancer development. Here, we report identification of a novel lncRNA, termed TP53-inhibiting lncRNA (TILR), which was found to function as a constitutive negative
Autor:
Dejan Juric, Jeffrey A. Engelman, Cyril H. Benes, Hiromichi Ebi, Aditya Bardia, Leif W. Ellisen, Nicholas J. Dyson, James R. Stone, Mari Mino-Kenudson, Christopher J. Pinto, Ioannis Sanidas, Daria Timonina, Leah J. Damon, Laura E. Henderson, Charles T. Jakubik, Shogo Yanase, Rachel Peterson, Christopher Healy, Tiffany Huynh, Charlotte S. Walmsley, Ellen Murchie, Yasuyuki Hosono, Amy Ly, Ye Wang, Carlotta Costa
Supplementary Figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b723650133405abfb9014d897936b55
https://doi.org/10.1158/2159-8290.22529202
https://doi.org/10.1158/2159-8290.22529202
Autor:
Anthony C. Faber, Hiromichi Ebi, Yasushi Yatabe, Sosipatros Boikos, Aaron N. Hata, Andrew J. Souers, Joel D. Leverson, Hisashi Harada, Jennifer E. Koblinski, Yuko Oya, Brad E. Windle, Colin M. Coon, Krista M. Powell, Bin Hu, Jungoh Ham, Neha U. Patel, Yoshiko Murakami, Timothy L. Lochmann, Sheeba Jacob, Crystal Turner, Yasuyuki Hosono, Kyung-A Song
Sup. Table 2. Top 3 functional pathways from ingenuity pathways analysis (IPA) in DTC.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f74674081412f56da2d0227724443a2d
https://doi.org/10.1158/1078-0432.22470600
https://doi.org/10.1158/1078-0432.22470600
Autor:
Anthony C. Faber, Hiromichi Ebi, Yasushi Yatabe, Sosipatros Boikos, Aaron N. Hata, Andrew J. Souers, Joel D. Leverson, Hisashi Harada, Jennifer E. Koblinski, Yuko Oya, Brad E. Windle, Colin M. Coon, Krista M. Powell, Bin Hu, Jungoh Ham, Neha U. Patel, Yoshiko Murakami, Timothy L. Lochmann, Sheeba Jacob, Crystal Turner, Yasuyuki Hosono, Kyung-A Song
Purpose: EGFR inhibitors (EGFRi) are effective against EGFR-mutant lung cancers. The efficacy of these drugs, however, is mitigated by the outgrowth of resistant cells, most often driven by a secondary acquired mutation in EGFR, T790M. We recently de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8c5caf81f01177aab3f3a1c79bfff3b
https://doi.org/10.1158/1078-0432.c.6527628.v1
https://doi.org/10.1158/1078-0432.c.6527628.v1
Autor:
Anthony C. Faber, Hiromichi Ebi, Yasushi Yatabe, Sosipatros Boikos, Aaron N. Hata, Andrew J. Souers, Joel D. Leverson, Hisashi Harada, Jennifer E. Koblinski, Yuko Oya, Brad E. Windle, Colin M. Coon, Krista M. Powell, Bin Hu, Jungoh Ham, Neha U. Patel, Yoshiko Murakami, Timothy L. Lochmann, Sheeba Jacob, Crystal Turner, Yasuyuki Hosono, Kyung-A Song
Figure S1. DTCs upregulate TORC1-mediated MCL-1 translation. Figure S2. High-content cell imaging assay. Figure S3. Genetic inhibition of MCL-1 is sufficient to induce apoptosis following EGFR inhibitor treatment. Figure S4. EGFR mutant tumors (PC9)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca0f590fae8b05bba56e528b2e7a6d98
https://doi.org/10.1158/1078-0432.22470609
https://doi.org/10.1158/1078-0432.22470609