A clinically applicable and scalable method to regenerate T-cells from iPSCs for off-the-shelf T-cell immunotherapy

Autor: Shoichi Iriguchi, Yutaka Yasui, Yohei Kawai, Suguru Arima, Mihoko Kunitomo, Takayuki Sato, Tatsuki Ueda, Atsutaka Minagawa, Yuta Mishima, Nariaki Yanagawa, Yuji Baba, Yasuyuki Miyake, Kazuhide Nakayama, Maiko Takiguchi, Tokuyuki Shinohara, Tetsuya Nakatsura, Masaki Yasukawa, Yoshiaki Kassai, Akira Hayashi, Shin Kaneko

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)

T-cell immunotherapies, such as CAR-T immunotherapy, are being developed against a wide variety of diseases. Here the authors report the feeder-free, scalable differentiation of human induced pluripotent cells (iPSCs) to T-cells with T-cell receptor

Externí odkaz: https://doaj.org/article/12a17ede1fbe4df1bb06b871dd8b9d04

Influenza A virus uses actomyosin for genome packaging at the cell membrane

Autor: I-Hsuan Wang, Jiro Usukura, Yasuyuki Miyake, Eiji Usukura, Akihiro Narita, Toshiaki Endou, Yohei Yamauchi, Yoshihiro Kawaoka

Influenza A virus encodes its genome in eight segments of viral ribonucleopropteins (vRNPs) replicated in the cell nucleus. Clustering of the eight vRNPs is thought to be a selective process promoted by negative-strand RNA interactions. Here, we visu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f3ecbd26e124ca7a77c298535d301691
https://doi.org/10.21203/rs.3.rs-2558009/v1

Generation of macrophages with altered viral sensitivity from genome-edited rhesus macaque iPSCs to model human disease

Autor: Yasuyuki Miyake, Emi E. Nakayama, Shoichi Iriguchi, Yohei Seki, Tomoyuki Miura, Tatsuo Shioda, Kahoru Taya, Masahiro Tanaka, Akifumi Takaori-Kondo, Hirofumi Akari, Shin Kaneko, Yoshihiro Iwamoto

Publikováno v: Molecular Therapy: Methods & Clinical Development, Vol 21, Iss, Pp 262-273 (2021)
Molecular Therapy. Methods & Clinical Development

Because of their close biological similarity to humans, non-human primate (NHP) models are very useful for the development of induced pluripotent stem cell (iPSC)-based cell and regenerative organ transplantation therapies. However, knowledge on the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9127a7ff33fe08719ff0b193a2e74b02
http://hdl.handle.net/2433/275683

A clinically applicable and scalable method to regenerate T-cells from iPSCs for off-the-shelf T-cell immunotherapy

Autor: Shin Kaneko, Tatsuki Ueda, Mihoko Kunitomo, Yasuyuki Miyake, Yuji Baba, Tokuyuki Shinohara, Akira Hayashi, Kazuhide Nakayama, Yoshiaki Kassai, Shoichi Iriguchi, Yutaka Yasui, Nariaki Yanagawa, Maiko Takiguchi, Yohei Kawai, Suguru Arima, Atsutaka Minagawa, Masaki Yasukawa, Takayuki Sato, Tetsuya Nakatsura, Yuta Mishima

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications

Clinical successes demonstrated by chimeric antigen receptor T-cell immunotherapy have facilitated further development of T-cell immunotherapy against wide variety of diseases. One approach is the development of “off-the-shelf” T-cell sources. Te

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::591c0b8a8aac0b92494fa088d4a4dddb
https://doaj.org/article/12a17ede1fbe4df1bb06b871dd8b9d04

Disrupting the HDAC6-ubiquitin interaction impairs infection by influenza and Zika virus and cellular stress pathways

Autor: Longlong Wang, Etori Aguiar Moreira, Georg Kempf, Yasuyuki Miyake, Blandina I. Oliveira Esteves, Amal Fahmi, Jonas V. Schaefer, Birgit Dreier, Yohei Yamauchi, Marco P. Alves, Andreas Plückthun, Patrick Matthias

Publikováno v: Wang, Longlong; Moreira, Etori Aguiar; Kempf, Georg; Miyake, Yasuyuki; Oliveira Esteves, Blandina I; Fahmi, Amal; Schaefer, Jonas V; Dreier, Birgit; Yamauchi, Yohei; Alves, Marco P; Plückthun, Andreas; Matthias, Patrick (2022). Disrupting the HDAC6-ubiquitin interaction impairs infection by influenza and Zika virus and cellular stress pathways. Cell reports, 39(4), p. 110736. Cell Press 10.1016/j.celrep.2022.110736
Cell Reports, 39 (4)

The deacetylase HDAC6 has tandem catalytic domains and a zinc finger domain (ZnF) binding ubiquitin (Ub). While the catalytic domain has an antiviral effect, the ZnF facilitates influenza A virus (IAV) infection and cellular stress responses. By recr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cf8a87a1744916c2a10e9156cf482c6
https://boris.unibe.ch/169575/1/1-s2.0-S2211124722004971-main.pdf