Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Yasuyuki, Gen"'
Autor:
Tomohiro Soda, Yasuyuki Gen, Kei Terasaki, Naoto Iwai, Tomoko Kitaichi, Osamu Dohi, Hiroyoshi Taketani, Yuya Seko, Atsushi Umemura, Taichiro Nishikawa, Kanji Yamaguchi, Michihisa Moriguchi, Hideyuki Konishi, Yuji Naito, Yoshito Itoh, Kohichiroh Yasui
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Signet-ring cell carcinoma (SRCC) is a unique subtype of gastric cancer that is impaired for cell–cell adhesion. The pathogenesis of SRCC remains unclear. Here, we show that expression of kinesin-associated protein 3 (KAP3), a cargo adapto
Externí odkaz:
https://doaj.org/article/bec98801d67c4a62b99b65ef2b2789ea
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 25, Iss , Pp 83-92 (2021)
Neuroblastoma (NB) harboring MYCN amplification is a refractory disease with a poor prognosis. As BRD4, an epigenetic reader belonging to the bromodomain and extra terminal domain (BET) family, drives transcription of MYCN in NB cells, BET inhibitors
Externí odkaz:
https://doaj.org/article/5c52b700abb940eb83fcf4f444ce6981
Supplementary Figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::072a71d4793344d17cc66e09566cc607
https://doi.org/10.1158/0008-5472.22429944
https://doi.org/10.1158/0008-5472.22429944
Super-enhancers (SE) are clusters of transcription enhancers that drive gene expression. SEs are typically characterized by high levels of acetylation of histone H3 lysine 27 (H3K27ac), which is catalyzed by the histone lysine acetyltransferase CREB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54a3abd746c5949fd87198b8aae99d4f
https://doi.org/10.1158/0008-5472.c.6513495
https://doi.org/10.1158/0008-5472.c.6513495
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 25, Iss, Pp 83-92 (2021)
Neuroblastoma (NB) harboring MYCN amplification is a refractory disease with a poor prognosis. As BRD4, an epigenetic reader belonging to the bromodomain and extra terminal domain (BET) family, drives transcription of MYCN in NB cells, BET inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fd9c2a635dd022b2174b1e0ba0bcdf6
https://doi.org/10.1016/j.omtn.2021.05.001
https://doi.org/10.1016/j.omtn.2021.05.001
Publikováno v:
Cancer Research. 81:5190-5201
Super-enhancers (SE) are clusters of transcription enhancers that drive gene expression. SEs are typically characterized by high levels of acetylation of histone H3 lysine 27 (H3K27ac), which is catalyzed by the histone lysine acetyltransferase CREB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14cc6a8e6beb6bd9dbf766d5fdbaaf1d
https://doi.org/10.1158/0008-5472.can-21-0649
https://doi.org/10.1158/0008-5472.can-21-0649
Publikováno v:
Endoscopy International Open, Vol 04, Iss 06, Pp E608-E609 (2016)
We report the case of a 55-year-old woman with a tumor in the greater curvature of the upper gastric body. The tumor was incidentally found on an upper gastrointestinal X-ray series performed during a routine medical examination. Whereas endoscopy re
Externí odkaz:
https://doaj.org/article/dc3b8691a939468886bd17dfd33a088a
Autor:
Osamu Dohi, Kohichiroh Yasui, Tomoko Kitaichi, Kei Terasaki, Kanji Yamaguchi, Yoshio Sumida, Nobuhisa Yamada, Naoto Iwai, Yoshito Itoh, Hironori Mitsuyoshi, Atsushi Umemura, Yuji Naito, Taichiro Nishikawa, Yasuyuki Gen, Yoh Zen, Michihisa Moriguchi, Akira Tomie
Publikováno v:
Human Pathology. 62:134-140
Disrupted cell polarity is a feature of epithelial cancers. The partitioning defective 3 (PAR-3) protein, a key component of the PAR complex that regulates the polarization of cells, is involved in tight junction formation at epithelial cell-cell con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63ccda5eb6dfe6b35c47d0e0d7c36f4a
https://doi.org/10.1016/j.humpath.2017.01.009
https://doi.org/10.1016/j.humpath.2017.01.009
Autor:
Yasuyuki Gen, Kousuke Tanimoto, Hiroyuki Harada, Yuki Takagawa, Tomoki Muramatsu, Jun Inoue, Johji Inazawa
Publikováno v:
Mol Ther
BRD4, a member of the bromodomain and extra-terminal domain (BET) protein family, plays a role in the organization of super-enhancers and transcriptional activation of oncogenes in cancer and is recognized as a promising target for cancer therapy. mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99eb909f4fc0f18de77749d8482b11c6
https://pubmed.ncbi.nlm.nih.gov/32320642
https://pubmed.ncbi.nlm.nih.gov/32320642