Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Yasuyoshi Tanaka"'
Autor:
Kouya Uchino, Yasuyoshi Tanaka, Sayaka Kawaguchi, Kaori Kubota, Takuya Watanabe, Shutaro Katsurabayashi, Shinichi Hirose, Katsunori Iwasaki
Publikováno v:
iScience, Vol 25, Iss 8, Pp 104762- (2022)
Summary: Although astrocytes are involved in the pathogenesis of CNS diseases, how they induce synaptic abnormalities is unclear. Currently, in vitro pathological astrocyte cultures or animal models do not reproduce human disease phenotypes accuratel
Externí odkaz:
https://doaj.org/article/ce3626d253714dad88b47e325662acdd
Autor:
Kouya Uchino, Hiroyuki Kawano, Yasuyoshi Tanaka, Yuna Adaniya, Ai Asahara, Masanobu Deshimaru, Kaori Kubota, Takuya Watanabe, Shutaro Katsurabayashi, Katsunori Iwasaki, Shinichi Hirose
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Dravet syndrome (DS) is an intractable form of childhood epilepsy that occurs in infancy. More than 80% of all patients have a heterozygous abnormality in the SCN1A gene, which encodes a subunit of Na+ channels in the brain. However, the det
Externí odkaz:
https://doaj.org/article/f6e6c8cce3c4492e8c1aea934931d3d8
Autor:
Yuichi Kimura, Yasuyoshi Tanaka, Naoto Shirasu, Shin'ichiro Yasunaga, Norimichi Higurashi, Shinichi Hirose
Publikováno v:
Stem Cell Research, Vol 47, Iss , Pp 101857- (2020)
Dravet syndrome is known as an intractable infantile epilepsy caused by a heterozygous de novo mutation in SCN1A, with mutations being reported globally. In this study, we established 2 human induced pluripotent stem cell lines by expressing reprogra
Externí odkaz:
https://doaj.org/article/5b1abb0310234aae8903a4cd7522c93e
Autor:
Yasuyoshi Tanaka, Norimichi Higurashi, Naoto Shirasu, Shin'ichiro Yasunaga, Kevin Mello Moreira, Hideyuki Okano, Shinichi Hirose
Publikováno v:
Stem Cell Research, Vol 31, Iss , Pp 11-15 (2018)
De novo mutations in SCN1A are the most common cause of Dravet syndrome (DS), an infantile-onset epileptic encephalopathy. In this study, human induced pluripotent stem cell (hiPSC) line FUi002-A was generated from skin fibroblasts obtained from a cl
Externí odkaz:
https://doaj.org/article/a0f2c7162ba54700b42cb8556ca35620
Autor:
Yasuyoshi Tanaka, Takefumi Sone, Norimichi Higurashi, Tetsushi Sakuma, Sadafumi Suzuki, Mitsuru Ishikawa, Takashi Yamamoto, Jun Mitsui, Hitomi Tsuji, Hideyuki Okano, Shinichi Hirose
Publikováno v:
Stem Cell Research, Vol 28, Iss , Pp 100-104 (2018)
Dravet syndrome (DS) is an infantile epileptic encephalopathy mainly caused by de novo mutations in the SCN1A gene encoding the α1 subunit of the voltage-gated sodium channel Nav1.1. As an in vitro model of this disease, we previously generated an i
Externí odkaz:
https://doaj.org/article/b6a2d611a12444fa922b7b645f0a31e2
Autor:
Yuko Tomonoh, Masanobu Deshimaru, Kimi Araki, Yasuhiro Miyazaki, Tomoko Arasaki, Yasuyoshi Tanaka, Haruna Kitamura, Fumiaki Mori, Koichi Wakabayashi, Sayaka Yamashita, Ryo Saito, Masayuki Itoh, Taku Uchida, Junko Yamada, Keisuke Migita, Shinya Ueno, Hiroki Kitaura, Akiyoshi Kakita, Christoph Lossin, Yukio Takano, Shinichi Hirose
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e88549 (2014)
Knock-in mouse models have contributed tremendously to our understanding of human disorders. However, generation of knock-in animals requires a significant investment of time and effort. We addressed this problem by developing a novel knock-in system
Externí odkaz:
https://doaj.org/article/39c916144d874070b91a1e1527fbd817
Autor:
Kouya Uchino, Yasuyoshi Tanaka, Wakana Ikezawa, Masanobu Deshimaru, Kaori Kubota, Takuya Watanabe, Shutaro Katsurabayashi, Katsunori Iwasaki, Shinichi Hirose
Publikováno v:
Biochemical and Biophysical Research Communications. 643:169-174
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d55f797c962f2a8926a76514bad78309
https://doi.org/10.1016/j.bbrc.2022.12.084
https://doi.org/10.1016/j.bbrc.2022.12.084
Autor:
Kouya, Uchino, Yasuyoshi, Tanaka, Wakana, Ikezawa, Masanobu, Deshimaru, Kaori, Kubota, Takuya, Watanabe, Shutaro, Katsurabayashi, Katsunori, Iwasaki, Shinichi, Hirose
Publikováno v:
Biochemical and biophysical research communications. 643
Dravet syndrome (DS) is an infantile-onset epileptic encephalopathy. More than 80% of DS patients have a heterozygous mutation in SCN1A, which encodes a subunit of the voltage-gated sodium channel, Nav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::abfe3bc3bb78a0af683742923a5b72c8
https://pubmed.ncbi.nlm.nih.gov/36610382
https://pubmed.ncbi.nlm.nih.gov/36610382
Autor:
Toshihisa Takeuchi, Ryoji Koshiba, Takako Miyazaki, Sadaharu Nouda, Ken Kawakami, Shiro Nakamura, Naohiko Kinoshita, Yutaka Naka, Kazuhiro Ota, Takuya Inoue, Kei Nakazawa, Kazuhide Higuchi, Hideki Tawa, Makoto Sanomura, Yuki Hirata, Yasuyoshi Tanaka, Yutaka Saito, Kazuki Kakimoto
Publikováno v:
Internal Medicine
Objective Although colorectal polyps (CPs) can be observed with colon capsule endoscopy (CCE), it is difficult to determine the type of polyp using CCE. The objective of this study was to differentiate adenomatous polyps (APs) from hyperplastic polyp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97dde42d787b46e4ef41864883752469
https://doi.org/10.2169/internalmedicine.6446-20
https://doi.org/10.2169/internalmedicine.6446-20
Autor:
Yuichi Kojima, Takako Miyazaki, Kazuhide Higuchi, Yuki Hirata, Yasuhiro Ueda, Shiro Nakamura, Hiroyuki Tsujimoto, Kazuki Kakimoto, Ryoji Koshiba, Toshihisa Takeuchi, Kazuhiro Ota, Naohiko Kinoshita, Yasuyoshi Tanaka, Hideki Tawa
Publikováno v:
European Journal of Clinical Pharmacology. 77:1639-1648
Low-dose aspirin (LDA) administration prevents cerebral infarction and myocardial infarction, but many studies found an association with mucosal injury. Proton-pump inhibitors (PPIs) can prevent gastric and duodenal mucosal damage, but they may exace
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcd84fe3d6b5da72bf2f3689a4be9d42
https://doi.org/10.1007/s00228-021-03167-0
https://doi.org/10.1007/s00228-021-03167-0