Výsledky vyhledávání - "Yasuyo Sugawara"

Ivermectin represses Wnt/β-catenin signaling by binding to TELO2, a regulator of phosphatidylinositol 3-kinase-related kinases

Autor: Honami Yonezawa, Akari Ikeda, Ryo Takahashi, Haruka Endo, Yasuyo Sugawara, Mikako Goto, Mirute Kanno, Sosuke Ogawa, Karin Nakamura, Haruki Ujiie, Masato Iwatsuki, Tomoyasu Hirose, Toshiaki Sunazuka, Yoshimasa Uehara, Naoyuki Nishiya

Publikováno v: iScience. 25(3)

Ivermectin (IVM), an avermectin-derivative anthelmintic, specifically binds to glutamate-gated chloride ion channels (GluCls), causing paralysis in invertebrates. IVM also exhibits other biological activities such as Wnt/β-catenin pathway inhibition

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56ace8cde589d33a962ca57b77ff5b65
https://pubmed.ncbi.nlm.nih.gov/35530256

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Augmentation of the therapeutic efficacy of WEE 1 kinase inhibitor AZD 1775 by inhibiting the YAP –E2F1– DNA damage response pathway axis

Autor: Takaaki Tazawa, Naoyuki Nishiya, Yusuke Oku, Yasuyo Sugawara, Nanami Umezawa, Yoshimasa Uehara, Takaya Kobayashi

Publikováno v: FEBS Open Bio. 8:1001-1012

The main reasons for failure of cancer chemotherapy are intrinsic and acquired drug resistance. The Hippo pathway effector Yes-associated protein (YAP) is associated with resistance to both cytotoxic and molecular targeted drugs. Several lines of evi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fdf87201a7da6e194c909a3fa14a6e47
https://doi.org/10.1002/2211-5463.12440

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Orthodontic treatment of a patient with unilateral orofacial muscle dysfunction: The efficacy of myofunctional therapy on the treatment outcome

Autor: Yasuyo Sugawara, Teruko Takano-Yamamoto, Hiroshi Kamioka, Yoshihito Ishihara, Takashi Yamashiro

Publikováno v: American Journal of Orthodontics and Dentofacial Orthopedics. 150:167-180

The orofacial muscle is an important factor in the harmony of the occlusion, and its dysfunction significantly influences a patient's occlusion after craniofacial growth and development. In this case report, we describe the successful orthodontic tre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0f3315941c409ece96311e390bc886e
https://doi.org/10.1016/j.ajodo.2015.08.021

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Intérêts de l’utilisation des mini-vis orthodontiques en tant qu’ancrage indirect dans la correction de l’égression d’incisives mandibulaires pour un patient présentant une classe II hypodivergente

Autor: Yoshihito Ishihara, Yasuyo Sugawara, Takashi Yamashiro, Tarek A. Balam, Teruko Takano-Yamamoto, Shingo Kuroda

Publikováno v: L'Orthodontie Française. 87:229-243

Les anomalies dento-alvéolaires du sens vertical sont un problème commun chez les patients orthodontiques, mais restent souvent difficiles à traiter avec des mécaniques traditionnelles. Le cas décrit dans cet article illustre un traitement réal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4acc6f8ede9ff54db26e77744f2dd11d
https://doi.org/10.1051/orthodfr/2016022

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Oscillatory intracellular Ca2+ responses in living bone

Autor: Noriaki Kawanabe, Hiroshi Kamioka, Yasuyo Sugawara, Keiji Naruse, Yoshihito Ishihara, Takashi Yamashiro

Publikováno v: Journal of Oral Biosciences. 56:49-53

Intracellular calcium (Ca 2+ ) is an important secondary messenger that modulates many cellular processes. Its oscillatory signaling is considered to participate in the regulation of many different cell functions, including bone metabolism. However,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0a6b4f1e584a968c43de39b33c793a4e
https://doi.org/10.1016/j.job.2014.03.002

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Orthodontic correction of severe Class II malocclusion in a patient with Prader-Willi syndrome

Autor: Tomoki Kataoka, Ei Ei Hsu Hlaing, Yoshihito Ishihara, Naoya Odagaki, Teruko Takano-Yamamoto, Hiroshi Kamioka, Yasuyo Sugawara, Takashi Yamashiro, Miho Nasu

Publikováno v: American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics. 154(5)

Prader-Willi syndrome (PWS) is a complex disorder that affects multiple systems and may cause craniofacial and dentofacial abnormalities. However, there is still a lack of evidence in the literature regarding the progress of orthodontic treatment in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cbe1f3223e87d686270afb21dfa28fe
https://pubmed.ncbi.nlm.nih.gov/30384943

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The early mouse 3D osteocyte network in the presence and absence of mechanical loading

Autor: Takashi Yamashiro, Naoko Fujisawa, Noriaki Kawanabe, Yasuyo Sugawara, Yoshihito Ishihara, Hiroshi Kamioka

Publikováno v: Bone. 52:189-196

Osteocytes are considered to act as mechanosensory cells in bone. They form a functional synctia in which their processes become interconnected to constitute a three-dimensional (3D) network. Previous studies reported that in mice, the two-dimensiona

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9a6d7327afd1ee095ed865d31692c08
https://doi.org/10.1016/j.bone.2012.09.033

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Promotion of Ccn2 expression and osteoblastic differentiation by actin polymerization, which is induced by laminar fluid flow stress

Autor: Satoshi Kubota, Tadashi Honjo, Takashi Yamashiro, Teruko Takano-Yamamoto, Yasuyo Sugawara, Masaharu Takigawa, Yoshihito Ishihara, Hiroshi Kamioka

Publikováno v: Journal of Cell Communication and Signaling. 6:225-232

Fluid flow stress (FSS) is a major mechanical stress that induces bone remodeling upon orthodontic tooth movement, whereas CCN family protein 2 (CCN2) is a potent regenerator of bone defects. In this study, we initially evaluated the effect of lamina

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddd9eaaf8cd80de2b081736612d486f7
https://doi.org/10.1007/s12079-012-0177-z

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A Method for Observing Silver-Stained Osteocytes In Situ in 3-μm Sections Using Ultra-High Voltage Electron Microscopy Tomography

Autor: Yasuyo Sugawara, Takashi Yamashiro, Teruko Takano-Yamamoto, Yoshihito Ishihara, Sakhr A. Murshid, Naoko Kajimura, Ryoko Ando, Akio Takaoka, Hiroshi Kamioka, Toshiaki Hasegawa

Publikováno v: Microscopy and Microanalysis. 15:377-383

Osteocytes are surrounded by hard bone matrix, and it has not been possible previously to directly observe the in situ architecture of osteocyte morphology in bone. Electron microscope tomography, however, is a technique that has the unique potential

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8af12addc501a727a8f0447051e2de3f
https://doi.org/10.1017/s1431927609990420

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Primary cultures of chick osteocytes retain functional gap junctions between osteocytes and between osteocytes and osteoblasts

Autor: Soo Siang Lim, Sakhr A. Murshid, Yoshihito Ishihara, Hans Ris, Hiroshi Kamioka, Teruko Takano-Yamamoto, Yasuyo Sugawara

Publikováno v: Microscopy and Microanalysis. 13(2):108-117

The inaccessibility of osteocytes due to their embedment in the calcified bone matrix in vivo has precluded direct demonstration that osteocytes use gap junctions as a means of intercellular communication. In this article, we report successfully isol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::823b556b647e256fcbaf84f5b8b2343d
https://ousar.lib.okayama-u.ac.jp/32960

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