Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Yasuyo Tomishima"'
Autor:
Kenichi Washizuka, Yasuhiro Matsumura, Yasuyo Tomishima, Keiko Nakano, Naoko Unami, Fujiko Takamura, Takanobu Araki, Shigeo Matsui, Minoru Sakurai, Masashi Imanishi, Takao Yamamoto, Kaori Hamada, Kouji Hattori, Hitoshi Hamashima, Nobuhiro Yamamoto, Emiko Imamura, Hirofumi Ishikawa, Koji Ueshima, Yutaka Nakajima, Susumu Toda, Shinji Itou
Publikováno v:
Journal of Medicinal Chemistry. 52:3063-3072
As an extension of research conducted on beta(3)-adrenergic receptor agonists as potential drugs for treating overactive bladder (OAB), novel series containing an acylsulfonamide moiety instead of the carboxylic acid moiety were evaluated. These comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db696b5f389955fb00201a425aef2632
https://doi.org/10.1021/jm9000709
https://doi.org/10.1021/jm9000709
Autor:
Masashi, Imanishi, Yasuyo, Tomishima, Shinji, Itou, Hitoshi, Hamashima, Yutaka, Nakajima, Kenichi, Washizuka, Minoru, Sakurai, Shigeo, Matsui, Emiko, Imamura, Koji, Ueshima, Takao, Yamamoto, Nobuhiro, Yamamoto, Hirofumi, Ishikawa, Keiko, Nakano, Naoko, Unami, Kaori, Hamada, Yasuhiro, Matsumura, Fujiko, Takamura, Kouji, Hattori
Publikováno v:
Journal of Medicinal Chemistry. 51:1925-1944
A novel class of biphenyl analogues containing a benzoic acid moiety based on lead compound 8i have been identified as potent and selective human beta 3 adrenergic receptor (beta 3-AR) agonists with good oral bioavailability and long plasma half-life
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3df2218288fe87564bacbf9f841e0ed
https://doi.org/10.1021/jm701324c
https://doi.org/10.1021/jm701324c
Autor:
Yasuyo Tomishima, Kenichi Washizuka, Masayuki Kato, Hitoshi Hamashima, Yutaka Nakajima, Toshiko Miura, Hiroshi Kayakiri, Emiko Imamura, Hiroaki Ohtake
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:251-254
The discovery of a novel, potent and selective β3-adrenergic receptor (AR) agonist is described. SAR studies demonstrated the structural requirements for activity and selectivity. Compound 1c, which showed good β3-AR activity and selectivity, was i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46cba7b3143ff5d369186e60ac75f43d
https://doi.org/10.1016/j.bmcl.2004.11.001
https://doi.org/10.1016/j.bmcl.2004.11.001
Autor:
Kazuo Sakane, Satoru Kuroda, Hiromichi Itani, Atsushi Akahane, Fujiko Takamura, Yasuyo Tomishima, Yoshiyuki Tenda
Publikováno v:
CHEMICAL & PHARMACEUTICAL BULLETIN. 49:988-998
A novel series of 3-(2-substituted-3-oxo-2,3-dihydropyridazin-6-yl)-2-phenylpyrazolo[1,5-a]pyridines (5—38) were synthesized and evaluated for their in vitro adenosine A1 and A2A receptor binding activities, and in vitro metabolism by rat liver in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a50230e34ef837d9d0c35589252c6b9c
https://doi.org/10.1248/cpb.49.988
https://doi.org/10.1248/cpb.49.988
Autor:
Kazuo Sakane, Yasuyo Tomishima, Satoru Kuroda, Atsushi Akahane, Hiromichi Itani, Yoshiyuki Tenda, Fujiko Takamura
Publikováno v:
ChemInform. 33
A novel series of 3-(2-substituted-3-oxo-2,3-dihydropyridazin-6-yl)-2-phenylpyrazolo[1,5-a]pyridines (5—38) were synthesized and evaluated for their in vitro adenosine A1 and A2A receptor binding activities, and in vitro metabolism by rat liver in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::130c2858ba33180b3a52bb716b869a22
https://doi.org/10.1002/chin.200201153
https://doi.org/10.1002/chin.200201153
Autor:
Kaori Hamada, Yasuyo Tomishima, Emiko Imamura, Shigeo Matsui, Naoko Unami, Masashi Imanishi, Takao Yamamoto, Keiko Nakano, Fujiko Takamura, Hitoshi Hamashima, Nobuhiro Yamamoto, Minoru Sakurai, Kouji Hattori, Yutaka Nakajima, Yasuhiro Matsumura, Kenichi Washizuka, Koji Ueshima, Hirofumi Ishikawa
Publikováno v:
Journal of medicinal chemistry. 51(15)
We designed a series of benzoic acid derivatives containing the biphenyl ether or biphenyl template on the RHS and a phenylethanolaminotetraline (PEAT) skeleton, which was prepared by highly stereoselective synthesis, to generate two structurally dif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb31c6fe06954fe9a3f49fe06e88d3c3
https://pubmed.ncbi.nlm.nih.gov/18651730
https://pubmed.ncbi.nlm.nih.gov/18651730
Autor:
Keiko Nakano, Shinji Itou, Kenichi Washizuka, Koji Ueshima, Yasuyo Tomishima, Minoru Sakurai, Yasuhiro Matsumura, Hirofumi Ishikawa, Takanobu Araki, Hitoshi Hamashima, Nobuhiro Yamamoto, Fujiko Takamura, Naoko Unami, Kaori Hamada, Yutaka Nakajima, Masashi Imanishi, Takao Yamamoto, Shigeo Matsui, Kouji Hattori, Emiko Imamura
Publikováno v:
Journal of medicinal chemistry. 51(13)
The left-hand side (LHS) and central part of our first generation biphenyl (FGB) series was modified to improve in vitro and in vivo beta3-AR potency without loss of oral bioavailability. First, in this study, we focused our efforts on replacement of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57919344cacbb694f6897cec1da43b5f
https://pubmed.ncbi.nlm.nih.gov/18553954
https://pubmed.ncbi.nlm.nih.gov/18553954
Autor:
Shinji Itou, Kenichi Washizuka, Hitoshi Hamashima, Nobuhiro Yamamoto, Kaori Hamada, Yutaka Nakajima, Naoko Unami, Shigeo Matsui, Emiko Imamura, Takao Yamamoto, Yasuyo Tomishima, Minoru Sakurai, Masashi Imanishi, Hirofumi Ishikawa, Keiko Nakano, Koji Ueshima, Kouji Hattori
Publikováno v:
Bioorganicmedicinal chemistry letters. 18(18)
Identification and SAR study of novel series of beta(3)-AR agonists with benzoic acid are described. Conversion of ether linkage position of phenoxybenzoic acid derivative 2b led to compound 7b with moderate beta(3)-AR activity. Further modification
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66b24f96c0b2ad46c00c929f5063311b
https://pubmed.ncbi.nlm.nih.gov/18752946
https://pubmed.ncbi.nlm.nih.gov/18752946
Autor:
Emiko Imamura, Yutaka Nakajima, Masayuki Kato, Toshiko Miura, Hitoshi Hamashima, Hiroshi Kayakiri, Kenichi Washizuka, Yasuyo Tomishima, Hiroaki Ohtake
Publikováno v:
ChemInform. 36
The discovery of a novel, potent and selective β3-adrenergic receptor (AR) agonist is described. SAR studies demonstrated the structural requirements for activity and selectivity. Compound 1c, which showed good β3-AR activity and selectivity, was i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87d19b257542c4e77077769696b12866
https://doi.org/10.1002/chin.200519099
https://doi.org/10.1002/chin.200519099
Autor:
Masashi Imanishi, Yutaka Nakajima, Yasuyo Tomishima, Hitoshi Hamashima, Kenichi Washizuka, Minoru Sakurai, Shigeo Matsui, Emiko Imamura, Koji Ueshima, Takao Yamamoto, Nobuhiro Yamamoto, Hirofumi Ishikawa, Keiko Nakano, Naoko Unami, Kaori Hamada, Yasuhiro Matsumura, Fujiko Takamura, Kouji Hattori
Publikováno v:
Journal of Medicinal Chemistry; Jul2008, Vol. 51 Issue 15, p4804-4822, 19p