Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Yasutoshi Uchiyama"'
Autor:
Koichi Sumi, Patrick C. Reid, Shuying Jiang, Kabuto Takano, Toshiya Tanaka, Akira Watanabe, Mika Sugai, Makoto Naito, C Ikegame, Takao Hamakubo, Yutaka Midorikawa, Riuko Ohashi, Go Hasegawa, Y Hirayama, Yoshitaka Hippo, Hajime Umezu, Yasutoshi Uchiyama, Hiroyuki Aburatani, Juro Sakai, Kenji Daigo, Hiroko Iwanari, Tatsuhiko Kodama, Hiromitsu Hotta
Publikováno v:
The Journal of Pathology. 208:662-672
Hepatocyte nuclear factor-4alpha (HNF4alpha) exists in multiple isoforms that are generated by alternative promoter (P1 and P2) usage and splicing. Here we establish monoclonal antibodies (mAbs) for detecting P1 and P2 promoter-driven HNF4alpha, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f4c43d6d306c96a3bc832198ef8ff33
https://doi.org/10.1002/path.1928
https://doi.org/10.1002/path.1928
Autor:
Ying Huang, Yasutoshi Uchiyama, Hiroshi Kanamori, Tatsuhiko Kodama, Akihisa Takamizawa, Takefumi Doi, Masao Uchida, Takao Hamakubo
Publikováno v:
Hepatology Research. 23:90-97
The non-structural protein 5b (NS5b) of hepatitis C virus (HCV), bearing an RNA-dependent RNA polymerase (RdRp) activity, is considered as a new target of antiviral therapy. We expressed and purified the C-terminal 21 amino acid truncated NS5b protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8fb684c9c82763e3ae79e9353ca6520
https://doi.org/10.1016/s1386-6346(01)00167-x
https://doi.org/10.1016/s1386-6346(01)00167-x
Autor:
Hiroshi Kanamori, Yasutoshi Uchiyama, Takefumi Doi, Tatsuhiko Kodama, Takao Hamakubo, Akihisa Takamizawa, Takao Fujimura, Ying Huang
Publikováno v:
Biochemical and Biophysical Research Communications. 281:732-740
Nonstructural (NS) proteins of hepatitis C virus (HCV) play major roles in viral replication and the pathogenesis of liver diseases. Current studies on antiviral strategies targeting these proteins have been hampered by the lack of efficient cell cul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f01f2e4e9cdaff776e4d2d7da71a243
https://doi.org/10.1006/bbrc.2001.4424
https://doi.org/10.1006/bbrc.2001.4424
Publikováno v:
Virology. 388(1)
We employed SELEX (systematic evolution of ligands by exponential enrichment) and identified high affinity RNA aptamers to the hepatitis C virus NS5B RNA-dependent RNA polymerase (RdRp). GC-rich stretches were identified in many of the aptamers. Dele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f49f62b9e2b52c2f7107a1ea878c59b
https://pubmed.ncbi.nlm.nih.gov/19328515
https://pubmed.ncbi.nlm.nih.gov/19328515
Autor:
Yumi Kobayashi, Tatsuhiko Kodama, Takefumi Doi, Yasutoshi Uchiyama, Keisuke Tachibana, Takao Hamakubo, Akira Sugiyama, Takahide Kohro, Masayuki Tagami, Chihiro Ueda, Daisuke Yamasaki, Juro Sakai, Tatsuya Katayama, Kenji Ishimoto, Mikako Sumitomo, Toshiya Tanaka
Publikováno v:
Nuclear Receptor
Background Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors and commonly play an important role in the regulation of lipid homeostasis. To identify human PPARs-responsive genes, we established tetracyclin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5610f0302520017f6939f4e66bab891
https://doi.org/10.1186/1478-1336-3-3
https://doi.org/10.1186/1478-1336-3-3
Autor:
Yasutoshi Uchiyama, Toshiya Tanaka, Wakako Takabe, Tatsuhiko Kodama, Riuko Ohashi, Keiko Katsumi, Hiroko Iwanari, Makoto Naito, Shuying Jiang, Noriko Noguchi, Yuichiro Watanabe, Takao Hamakubo
Publikováno v:
Arteriosclerosis, thrombosis, and vascular biology. 25(3)
Objective— Liver X–activated receptor α (LXRα) regulates multiple genes controlling cholesterol metabolism and transport. To clarify its role in atherogenesis, we established a monoclonal antibody recognizing native human LXRα protein and stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f5e84c6d6b334bb1389c965d1cc7f6b
https://pubmed.ncbi.nlm.nih.gov/15625283
https://pubmed.ncbi.nlm.nih.gov/15625283
Autor:
Takao Hamakubo, Kenta Magoori, Johan Auwerx, Koichi Sumi, Satoshi Iwasaki, Yasutoshi Uchiyama, Yukio Ikeda, Tatsuhiko Kodama, Juro Sakai, Keisuke Tachibana, Takefumi Doi, Masashi Yanagisawa, Hiroshi Asaba, Hiroki Hamura, Ryoichi X. Ioka, Haruhisa Iguchi, Makoto Naito, Yuichiro Watanabe, Joji Yamamoto, Toshiya Tanaka, Mitsuhiro Watanabe, Sadayoshi Ito
In this study, we defined the role of peroxisome proliferator-activated receptor β/δ (PPARδ) in metabolic homeostasis by using subtype selective agonists. Analysis of rat L6 myotubes treated with the PPARδ subtype-selective agonist, GW501516, by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c1468df9c890296bac4a73959f643aa
https://europepmc.org/articles/PMC307669/
https://europepmc.org/articles/PMC307669/
Autor:
Rie Fukuda, Makoto Naito, Kazuaki Takahashi, Tatsuhiko Kodama, Shuying Jiang, Kazuyuki Masuda, Yasutoshi Uchiyama, Hiroko Iwanari, Mineko Yamaguchi, Takao Hamakubo, Yasuomi Urano
Publikováno v:
Biochemical and biophysical research communications. 308(1)
The baculovirus expression system has been used to express large quantities of various proteins, including membrane receptors. Here, we reveal a novel property of this expression system to be that certain membrane proteins can be displayed on the bud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1188412d305c6175cf269f53573878c3
https://pubmed.ncbi.nlm.nih.gov/12890500
https://pubmed.ncbi.nlm.nih.gov/12890500
Autor:
Shuying, Jiang, Toshiya, Tanaka, Hiroko, Iwanari, Hiromitsu, Hotta, Hisahiko, Yamashita, Junko, Kumakura, Yuichiro, Watanabe, Yasutoshi, Uchiyama, Hiroyuki, Aburatani, Takao, Hamakubo, Tatsuhiko, Kodama, Makoto, Naito
Publikováno v:
Nuclear Receptor
Background Hepatocyte nuclear factor-4α (HNF4α; NR2A1) is an orphan member of the nuclear receptor superfamily involved in various processes that could influence endoderm development, glucose and lipid metabolism. A loss-of-function mutation in hum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::626523e09983f27482ce412d89848c11
https://pubmed.ncbi.nlm.nih.gov/12952540
https://pubmed.ncbi.nlm.nih.gov/12952540
Autor:
Yuichiro, Watanabe, Toshiya, Tanaka, Yasutoshi, Uchiyama, Tetsu, Takeno, Akashi, Izumi, Hisahiko, Yamashita, Junko, Kumakura, Hiroko, Iwanari, Jiang, Shu-Ying, Makoto, Naito, David J, Mangelsdorf, Takao, Hamakubo, Tatsuhiko, Kodama
Publikováno v:
Nuclear Receptor
Liver X activated receptor alpha (LXRalpha) forms a functional dimeric nuclear receptor with RXR that regulates the metabolism of several important lipids, including cholesterol and bile acids. As compared with RXR, the LXRalpha protein level in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::adbb6e5c1d2548786bbf98738ee4fbd0
https://pubmed.ncbi.nlm.nih.gov/12904258
https://pubmed.ncbi.nlm.nih.gov/12904258