Zobrazeno 1 - 10
of 91
pro vyhledávání: '"Yasutoshi Akiyama"'
Autor:
Akitaka Yamasaki, Rikuto Miyake, Yuta Hara, Hideki Okuno, Takuya Imaida, Kouki Okita, Shogo Okazaki, Yasutoshi Akiyama, Kenji Hirotani, Yuichi Endo, Kazue Masuko, Takashi Masuko, Yoshihisa Tomioka
Publikováno v:
Cancer Medicine, Vol 12, Iss 8, Pp 9684-9696 (2023)
Abstract Background Colorectal cancer (CRC) is the most common malignancy in the world, and novel molecular targeted therapies for CRC have been vigorously pursued. We searched for novel combination therapies based on the expression patterns of membr
Externí odkaz:
https://doaj.org/article/77ea5f9525074b0dbd229b20ff2ad641
Autor:
Yasutoshi Akiyama, Shawn M. Lyons, Marta M. Fay, Yoshihisa Tomioka, Takaaki Abe, Paul J. Anderson, Pavel Ivanov
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Stress-induced tRNA cleavage has been implicated in various cellular processes, where tRNA fragments play diverse regulatory roles. Angiogenin (ANG), a member of the RNase A superfamily, induces cleavage of tRNAs resulting in the formation of tRNA-de
Externí odkaz:
https://doaj.org/article/5aeb2346071c4703bb21e9e8b55d3354
Autor:
Koichi Kikuchi, Daisuke Saigusa, Yoshitomi Kanemitsu, Yotaro Matsumoto, Paxton Thanai, Naoto Suzuki, Koki Mise, Hiroaki Yamaguchi, Tomohiro Nakamura, Kei Asaji, Chikahisa Mukawa, Hiroki Tsukamoto, Toshihiro Sato, Yoshitsugu Oikawa, Tomoyuki Iwasaki, Yuji Oe, Tomoya Tsukimi, Noriko N. Fukuda, Hsin-Jung HO, Fumika Nanto-Hara, Jiro Ogura, Ritsumi Saito, Shizuko Nagao, Yusuke Ohsaki, Satoshi Shimada, Takehiro Suzuki, Takafumi Toyohara, Eikan Mishima, Hisato Shima, Yasutoshi Akiyama, Yukako Akiyama, Mariko Ichijo, Tetsuro Matsuhashi, Akihiro Matsuo, Yoshiaki Ogata, Ching-Chin Yang, Chitose Suzuki, Matthew C. Breeggemann, Jurgen Heymann, Miho Shimizu, Susumu Ogawa, Nobuyuki Takahashi, Takashi Suzuki, Yuji Owada, Shigeo Kure, Nariyasu Mano, Tomoyoshi Soga, Takashi Wada, Jeffrey B. Kopp, Shinji Fukuda, Atsushi Hozawa, Masayuki Yamamoto, Sadayoshi Ito, Jun Wada, Yoshihisa Tomioka, Takaaki Abe
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Diabetes is a major cause of kidney disease. Here Kikuchi et al. show that phenol sulfate, a gut microbiota-derived metabolite, is increased in diabetic kidney disease and contributes to the pathology by promoting kidney injury, suggesting phenyl sul
Externí odkaz:
https://doaj.org/article/4b7ee8aaa8cd44e3ba881e3d9e920e28
Autor:
Akitaka Yamasaki, Kumiko Maruyama‐Takahashi, Kento Nishida, Shogo Okazaki, Kouki Okita, Yasutoshi Akiyama, Hideaki Suzuki, Yuichi Endo, Kazue Masuko, Takashi Masuko, Yoshihisa Tomioka
Publikováno v:
Genes to Cells. 28:374-382
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b269059a70b43b91b4e33e4b2e4ae5a
https://doi.org/10.1111/gtc.13016
https://doi.org/10.1111/gtc.13016
Autor:
Akitaka Yamasaki, Rikuto Miyake, Yuta Hara, Hideki Okuno, Takuya Imaida, Kouki Okita, Shogo Okazaki, Yasutoshi Akiyama, Kenji Hirotani, Yuichi Endo, Kazue Masuko, Takashi Masuko, Yoshihisa Tomioka
Publikováno v:
Cancer Medicine. 12:9684-9696
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aab665de2823f44a1527c0719171bf31
https://doi.org/10.1002/cam4.5673
https://doi.org/10.1002/cam4.5673
Autor:
Yoshitsugu Oikawa, Rumiko Izumi, Masashi Koide, Yoshihiro Hagiwara, Makoto Kanzaki, Naoki Suzuki, Koichi Kikuchi, Tetsuro Matsuhashi, Yukako Akiyama, Mariko Ichijo, Shun Watanabe, Takafumi Toyohara, Takehiro Suzuki, Eikan Mishima, Yasutoshi Akiyama, Yoshiaki Ogata, Chitose Suzuki, Hironori Hayashi, Eiichi N Kodama, Ken-Ichiro Hayashi, Eiji Itoi, Masashi Aoki, Shigeo Kure, Takaaki Abe
Publikováno v:
PLoS ONE, Vol 15, Iss 12, p e0231064 (2020)
Sporadic inclusion body myositis (sIBM) is the most common idiopathic inflammatory myopathy, and several reports have suggested that mitochondrial abnormalities are involved in its etiology. We recruited 9 sIBM patients and found significant histolog
Externí odkaz:
https://doaj.org/article/860982a4489c488f8f33915ef4480d2e
Autor:
Tetsuro Matsuhashi, Takeya Sato, Shin-ichiro Kanno, Takehiro Suzuki, Akihiro Matsuo, Yuki Oba, Motoi Kikusato, Emi Ogasawara, Tai Kudo, Kosuke Suzuki, Osamu Ohara, Hiroko Shimbo, Fumika Nanto, Hiroaki Yamaguchi, Daisuke Saigusa, Yasuno Mukaiyama, Akiko Watabe, Koichi Kikuchi, Hisato Shima, Eikan Mishima, Yasutoshi Akiyama, Yoshitsugu Oikawa, HO Hsin-Jung, Yukako Akiyama, Chitose Suzuki, Mitsugu Uematsu, Masaki Ogata, Naonori Kumagai, Masaaki Toyomizu, Atsushi Hozawa, Nariyasu Mano, Yuji Owada, Setsuya Aiba, Teruyuki Yanagisawa, Yoshihisa Tomioka, Shigeo Kure, Sadayoshi Ito, Kazuto Nakada, Ken-ichiro Hayashi, Hitoshi Osaka, Takaaki Abe
Publikováno v:
EBioMedicine, Vol 20, Iss C, Pp 27-38 (2017)
Mitochondrial dysfunction increases oxidative stress and depletes ATP in a variety of disorders. Several antioxidant therapies and drugs affecting mitochondrial biogenesis are undergoing investigation, although not all of them have demonstrated favor
Externí odkaz:
https://doaj.org/article/a69fd02b6914423ab9feee99f60fd27a
A novel indole compound MA-35 attenuates renal fibrosis by inhibiting both TNF-α and TGF-β1 pathways
Autor:
Hisato Shima, Kensuke Sasaki, Takehiro Suzuki, Chikahisa Mukawa, Ten Obara, Yuki Oba, Akihiro Matsuo, Takayasu Kobayashi, Eikan Mishima, Shun Watanabe, Yasutoshi Akiyama, Koichi Kikuchi, Tetsuro Matsuhashi, Yoshitsugu Oikawa, Fumika Nanto, Yukako Akiyama, Hsin-Jung Ho, Chitose Suzuki, Daisuke Saigusa, Atsushi Masamune, Yoshihisa Tomioka, Takao Masaki, Sadayoshi Ito, Ken-ichiro Hayashi, Takaaki Abe
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract Renal fibrosis is closely related to chronic inflammation and is under the control of epigenetic regulations. Because the signaling of transforming growth factor-β1 (TGF-β1) and tumor necrosis factor-α (TNF-α) play key roles in progressi
Externí odkaz:
https://doaj.org/article/f92c53843bc543f0a773d437d18edc10
Autor:
Yasutoshi Akiyama, Koichi Kikuchi, Takafumi Toyohara, Eikan Mishima, Chitose Suzuki, Takehiro Suzuki, Masaaki Nakayama, Yoshihisa Tomioka, Tomoyoshi Soga, Takaaki Abe
Publikováno v:
Toxins, Vol 13, Iss 5, p 324 (2021)
Uremic toxins are suggested to be involved in the pathophysiology of hemodialysis (HD) patients. However, the profile of uremic solutes in HD patients has not been fully elucidated. In this study using capillary electrophoresis mass spectrometry (CE-
Externí odkaz:
https://doaj.org/article/7522e9e5e3d1404e9dfade32097f1b17
Autor:
Yasutoshi Akiyama, Yoshika Takenaka, Tomoko Kasahara, Takaaki Abe, Yoshihisa Tomioka, Pavel Ivanov
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 21; Pages: 13100
Under stress conditions, transfer RNAs (tRNAs) are cleaved by stress-responsive RNases such as angiogenin, generating tRNA-derived RNAs called tiRNAs. As tiRNAs contribute to cytoprotection through inhibition of translation and prevention of apoptosi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25988eb00a6603cf71ef598dc6747305
https://pubmed.ncbi.nlm.nih.gov/36361884
https://pubmed.ncbi.nlm.nih.gov/36361884