Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Yasutoshi Agata"'
Autor:
Koji Terada, Kenta Kondo, Hirohito Ishigaki, Ayaka Nagashima, Hiroki Satooka, Seiji Nagano, Kyoko Masuda, Teruhisa Kawamura, Takako Hirata, Kazumasa Ogasawara, Yasushi Itoh, Hiroshi Kawamoto, Yasutoshi Agata
Publikováno v:
Molecular Therapy: Oncolytics, Vol 24, Iss , Pp 77-86 (2022)
To develop effective adoptive cell transfer therapy using T cell receptor (TCR)-engineered T cells, it is critical to isolate tumor-reactive TCRs that have potent anti-tumor activity. In humans, tumor-infiltrating lymphocytes (TILs) have been reporte
Externí odkaz:
https://doaj.org/article/26e650926bb94137978f4db5a627454b
Autor:
Takuya Maeda, Seiji Nagano, Soki Kashima, Koji Terada, Yasutoshi Agata, Hiroshi Ichise, Manami Ohtaka, Mahito Nakanishi, Fumihiro Fujiki, Haruo Sugiyama, Toshio Kitawaki, Norimitsu Kadowaki, Akifumi Takaori-Kondo, Kyoko Masuda, Hiroshi Kawamoto
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 19, Iss , Pp 250-260 (2020)
In the current adoptive T cell therapy, T cells from a patient are given back to that patient after ex vivo activation, expansion, or genetic manipulation. However, such strategy depends on the quality of the patient’s T cells, sometimes leading to
Externí odkaz:
https://doaj.org/article/e94f6375e43049b79591e27e60345c7a
Autor:
Soki Kashima, Takuya Maeda, Kyoko Masuda, Seiji Nagano, Takamitsu Inoue, Masashi Takeda, Yuka Kono, Takashi Kobayashi, Shigeyoshi Saito, Takahiro Higuchi, Hiroshi Ichise, Yuka Kobayashi, Keiko Iwaisako, Koji Terada, Yasutoshi Agata, Kazuyuki Numakura, Mitsuru Saito, Shintaro Narita, Masaki Yasukawa, Osamu Ogawa, Tomonori Habuchi, Hiroshi Kawamoto
Publikováno v:
iScience, Vol 23, Iss 4, Pp - (2020)
Summary: Current adoptive T cell therapies conducted in an autologous setting are costly, time consuming, and depend on the quality of the patient's T cells. To address these issues, we developed a strategy in which cytotoxic T lymphocytes (CTLs) are
Externí odkaz:
https://doaj.org/article/8642056a6e3e46368c7a690d7178da9a
Autor:
Tomokatsu Ikawa, Kyoko Masuda, Mirelle J.A.J. Huijskens, Rumi Satoh, Kiyokazu Kakugawa, Yasutoshi Agata, Tomohiro Miyai, Wilfred T.V. Germeraad, Yoshimoto Katsura, Hiroshi Kawamoto
Publikováno v:
Stem Cell Reports, Vol 5, Iss 5, Pp 716-727 (2015)
Self-renewal potential and multipotency are hallmarks of a stem cell. It is generally accepted that acquisition of such stemness requires rejuvenation of somatic cells through reprogramming of their genetic and epigenetic status. We show here that a
Externí odkaz:
https://doaj.org/article/75165807deb44108b1dc967407f67658
Autor:
Takuma Higuchi, Shuji Sakamoto, Yoshihiko Kakinuma, Shoko Kai, Ken-Ichi Yagyu, Hiroshi Todaka, Eunsup Chi, Shoshiro Okada, Takako Ujihara, Keiko Morisawa, Masafumi Ono, Yasunori Sugiyama, Waka Ishida, Atsuki Fukushima, Masayuki Tsuda, Yasutoshi Agata, Taketoshi Taniguchi
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e43340 (2012)
While NF90 has been known to participate in transcription, translation and microRNA biogenesis, physiological functions of this protein still remain unclear. To uncover this, we generated transgenic (Tg) mice using NF90 cDNA under the control of β-a
Externí odkaz:
https://doaj.org/article/c5f5758e301a4348b577a74f9c35a9a2
Autor:
Norimitsu Kadowaki, Fumihiro Fujiki, Koji Terada, Hiroshi Kawamoto, Hiroshi Ichise, Manami Ohtaka, Haruo Sugiyama, Akifumi Takaori-Kondo, Seiji Nagano, Toshio Kitawaki, Mahito Nakanishi, Takuya Maeda, Soki Kashima, Yasutoshi Agata, Kyoko Masuda
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 19, Iss, Pp 250-260 (2020)
Molecular Therapy. Methods & Clinical Development
Molecular Therapy. Methods & Clinical Development
In the current adoptive T cell therapy, T cells from a patient are given back to that patient after ex vivo activation, expansion, or genetic manipulation. However, such strategy depends on the quality of the patient’s T cells, sometimes leading to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2674c7494659da4d0da35cea3c69c2eb
http://www.sciencedirect.com/science/article/pii/S2329050120301960
http://www.sciencedirect.com/science/article/pii/S2329050120301960
Autor:
Mitsuru Saito, Shintaro Narita, Takuya Maeda, Takamitsu Inoue, Osamu Ogawa, Soki Kashima, Kazuyuki Numakura, Masaki Yasukawa, Hiroshi Kawamoto, Takashi Kobayashi, Kyoko Masuda, Seiji Nagano, Tomonori Habuchi, Yasutoshi Agata, Koji Terada
Publikováno v:
Journal of Urology. 206
INTRODUCTION AND OBJECTIVE:Since the checkpoint inhibitors are effective only in a small number of patients and often cause severe adverse events, we developed a novel immunotherapeutic strategy us...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1bf0a150805d4a299793d5b697b81fab
https://doi.org/10.1097/ju.0000000000002071.10
https://doi.org/10.1097/ju.0000000000002071.10
Autor:
Hirohito Ishigaki, Takako Hirata, Kagefumi Todo, Yasutoshi Agata, Hiroki Satooka, Yasushi Itoh, Kazumasa Ogasawara, Koji Terada
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Scientific Reports
Scientific Reports
Immunotherapy has emerged as a promising and effective treatment for cancer, yet the clinical benefit is still variable, in part due to insufficient accumulation of immune effector cells in the tumour microenvironment. Better understanding of tumour-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91ab5f3c9ef9a4cfa940b5f82096d311
http://hdl.handle.net/10422/00012723
http://hdl.handle.net/10422/00012723
Autor:
Kazuko Miyazaki, Susumu Kageyama, Akihiro Kawauchi, Masayuki Nagasawa, Koji Terada, Yasutoshi Agata, Hiroshi Kawamoto, Masaki Miyazaki, Daisuke Okuzaki, Kenta Kondo, Kosuke Tomimatsu, Daisuke Motooka, Tetsuya Yoshida
Publikováno v:
Biochemical and biophysical research communications. :S0006
Androgen receptor (AR)-negative castration-resistant prostate cancer (CRPC) is highly aggressive and is resistant to most of the current therapies. Bromodomain and extra terminal domain (BET) protein BRD4 binds to super-enhancers (SEs) that drive hig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c37e4a23fc64f7fa0514c71b96b3b7f6
http://hdl.handle.net/10422/00012645
http://hdl.handle.net/10422/00012645
Autor:
Shuwen Chen, Hans Reimer Rodewald, Rintaro Saito, Hiroshi Kawamoto, Keisuke Wagatsuma, Yasutoshi Agata, Aaron N. Chang, Nissi Varki, Kazuko Miyazaki, Masaki Miyazaki, Cornelis Murre, Vivek Chandra
Publikováno v:
Genes & Development. 29:409-425
It is now well established that the E and Id protein axis regulates multiple steps in lymphocyte development. However, it remains unknown how E and Id proteins mechanistically enforce and maintain the naïve T-cell fate. Here we show that Id2 and Id3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f5cc792be6f3aa4ee4a5d7de8a970aa
https://doi.org/10.1101/gad.255331.114
https://doi.org/10.1101/gad.255331.114