Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Yasutomo Nakanishi"'
Autor:
Hiroyuki Yamada, Hiroshi Mori, Yasutomo Nakanishi, Satoshi Nishikawa, Yasuaki Hashimoto, Yasuo Ochi, Makoto Tanaka, Kazuhito Kawabata
Publikováno v:
International Journal of Rheumatology, Vol 2019 (2019)
We examined whether the cathepsin K inhibitor, ONO-5334, administered alone or in combination with methotrexate (MTX), could ameliorate joint destruction evoked by collagen-induced arthritis (CIA) in female cynomolgus monkeys. CIA was induced by immu
Externí odkaz:
https://doaj.org/article/4183d52815b84a93a1a5b90905b65ffa
Publikováno v:
Folia Pharmacologica Japonica. 156:370-381
Anamorelin hydrochloride (hereinafter referred to as anamorelin) is an orally active, small-molecule drug with a similar pharmacological action to ghrelin, an endogenous ligand of growth hormone secretagogue receptor type 1a (GHS-R1a). It was first a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c7e65a9b8209aa65444ebfef02f1001
https://doi.org/10.1254/fpj.21046
https://doi.org/10.1254/fpj.21046
Publikováno v:
Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 156(6)
Anamorelin hydrochloride (hereinafter referred to as anamorelin) is an orally active, small-molecule drug with a similar pharmacological action to ghrelin, an endogenous ligand of growth hormone secretagogue receptor type 1a (GHS-R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d95239a4855a798611a97c96574de3b4
https://pubmed.ncbi.nlm.nih.gov/34719572
https://pubmed.ncbi.nlm.nih.gov/34719572
Autor:
Hiroshi Mori, Kazuhito Kawabata, Hiroyuki Yamada, Satoshi Nishikawa, Makoto Tanaka, Yasuaki Hashimoto, Yasutomo Nakanishi, Yasuo Ochi
Publikováno v:
International Journal of Rheumatology, Vol 2019 (2019)
International Journal of Rheumatology
International Journal of Rheumatology
We examined whether the cathepsin K inhibitor, ONO-5334, administered alone or in combination with methotrexate (MTX), could ameliorate joint destruction evoked by collagen-induced arthritis (CIA) in female cynomolgus monkeys. CIA was induced by immu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f2e81bc59ec91c9e19b13db6ef9e62b
https://doi.org/10.1155/2019/5710340
https://doi.org/10.1155/2019/5710340
Autor:
Makoto Tanaka, Akiko Kunishige, Yasuaki Hashimoto, Hiroyuki Yamada, Kazuhito Kawabata, Yasuo Ochi, Satoshi Nishikawa, Hiroshi Mori, Masafumi Sugitani, Naoki Kawada, Ryoji Kayasuga, Yasutomo Nakanishi
Publikováno v:
Bone. 65:1-8
This study examined the effect of ONO-5334, a cathepsin K inhibitor, on bone turnover, mineral density (BMD), mechanical strength and microstructure in ovariectomized (OVX) cynomolgus monkeys. Vehicle, ONO-5334 (3, 10 or 30 mg/kg) or alendronate (0.5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::450debfddc0964571e7a0dd89d80f3d7
https://doi.org/10.1016/j.bone.2014.04.023
https://doi.org/10.1016/j.bone.2014.04.023
Autor:
Kazuhito Kawabata, Makoto Tanaka, Yasutomo Nakanishi, Mark Bruce, Hiroshi Mori, Satoshi Nishikawa, Yasuo Ochi, Hiroyuki Yamada, Yasuaki Hashimoto, Steve Deacon
Publikováno v:
Bone. 86
We examined the effects of ONO-5334, a cathepsin K inhibitor, on bone markers, BMD, strength and histomorphometry in ovariectomized (OVX) cynomolgus monkeys. ONO-5334 (1.2, 6 and 30mg/kg/day, p.o.), alendronate (0.05mg/kg/2weeks, i.v.), or vehicle wa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53ffccdcc5715948effb2d0bf815d8a4
https://pubmed.ncbi.nlm.nih.gov/26921823
https://pubmed.ncbi.nlm.nih.gov/26921823
Autor:
Kazuhito Kawabata, Yasuo Ochi, Ryoji Kayasuga, Makoto Tanaka, Hiroyuki Yamada, Yasutomo Nakanishi, Masafumi Sugitani, Yasuaki Hashimoto, Naoki Kawada, Satoshi Nishikawa, Hiroshi Mori, Akiko Kunishige
Publikováno v:
Bone. 49(6)
In the present study, we examined the in vitro and in vivo pharmacological effects of ONO-5334, a novel inhibitor of cathepsin K, on bone metabolism. In vitro experiments indicated that ONO-5334 is a potent inhibitor of cathepsin K with Ki value of 0
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::965b1a79589e60fc6de4a349de7e203f
https://pubmed.ncbi.nlm.nih.gov/21982869
https://pubmed.ncbi.nlm.nih.gov/21982869
Publikováno v:
Prostaglandinsother lipid mediators. 74(1-4)
We examined whether cysteinyl leukotrienes (CysLTs) and thromboxane (TX) A2 are synergistically involved in a cedar pollen-induced allergic late phase nasal blockage in guinea pigs. Sensitized animals were repeatedly challenged by pollen inhalation o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0dcd609889b6486ffbe8928fa169e2a
https://pubmed.ncbi.nlm.nih.gov/15560121
https://pubmed.ncbi.nlm.nih.gov/15560121
Autor:
Hiroshi Mori, Kazuhito Kawabata, Yasuaki Hashimoto, Yasutomo Nakanishi, Satoshi Nishikawa, Hiroyuki Yamada, Masafumi Sugitani, Yasuo Ochi
Publikováno v:
Bone. 50:S157
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::580733f9bff5da111db990c0184d39ef
https://doi.org/10.1016/j.bone.2012.02.491
https://doi.org/10.1016/j.bone.2012.02.491