Zobrazeno 1 - 10
of 145
pro vyhledávání: '"Yasutomi Kamei"'
Autor:
Takumi Sugimoto, Chihiro Sakamaki, Tokushi Kimura, Takahiro Eguchi, Shinji Miura, Yasutomi Kamei
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract The neuromuscular junction (NMJ)—formed between a motor nerve terminal and skeletal muscle fiber—plays an important role in muscle contraction and other muscle functions. Aging and neurodegeneration worsen NMJ formation and impair muscle
Externí odkaz:
https://doaj.org/article/7fefd3daa26a4d87a81542a351ec23ff
Autor:
Naoki Ito, Ai Takatsu, Hiromi Ito, Yuka Koike, Kiyoshi Yoshioka, Yasutomi Kamei, Shin-ichiro Imai
Publikováno v:
Cell Reports, Vol 40, Iss 4, Pp 111131- (2022)
Summary: Sarcopenia and frailty are urgent socio-economic problems worldwide. Here we demonstrate a functional connection between the lateral hypothalamus (LH) and skeletal muscle through Slc12a8, a recently identified nicotinamide mononucleotide tra
Externí odkaz:
https://doaj.org/article/f1a75ef1c9d54561b570b5339832c901
Autor:
Shiho Nakai, Mamoru Oyabu, Yukino Hatazawa, Shiori Akashi, Tadahiro Kitamura, Shinji Miura, Yasutomi Kamei
Publikováno v:
FEBS Open Bio, Vol 10, Iss 7, Pp 1373-1388 (2020)
Peroxisome proliferator‐activated receptor‐gamma coactivator‐1β (PGC‐1β) is a transcriptional regulator whose increased expression activates energy expenditure‐related genes in skeletal muscles. However, how PGC‐1β is regulated remains
Externí odkaz:
https://doaj.org/article/dcc111fc955949049178ab941dca23e5
Autor:
Ran Uchitomi, Shiho Nakai, Rintaro Matsuda, Takumi Onishi, Shinji Miura, Yukino Hatazawa, Yasutomi Kamei
Publikováno v:
Biochemistry and Biophysics Reports, Vol 17, Iss , Pp 51-55 (2019)
PGC-1β is a transcriptional co-activator of nuclear receptors such as the estrogen receptor-related receptor (ERR). Transgenic overexpression of PGC-1β in mice increases energy expenditure and suppresses high-fat diet-induced obesity. In this study
Externí odkaz:
https://doaj.org/article/20cae27ad38a44deb61e6d5b00a725d0
Autor:
Junya Fujimaki, Neo Sayama, Shigenobu Shiotani, Takanori Suzuki, Miki Nonaka, Yasuhito Uezono, Mamoru Oyabu, Yasutomi Kamei, Haruo Nukaya, Keiji Wakabayashi, Akihito Morita, Tomoki Sato, Shinji Miura
Publikováno v:
Nutrients, Vol 14, Iss 5, p 1023 (2022)
The steroidal alkaloid tomatidine is an aglycone of α-tomatine, which is abundant in tomato leaves and has several biological activities. Tomatidine has been reported to inhibit the growth of cultured cancer cells in vitro, but its anti-cancer activ
Externí odkaz:
https://doaj.org/article/30be56f6148a4b2eb96bcbbe16b03141
Autor:
Xunmei Yuan, Kazutaka Tsujimoto, Koshi Hashimoto, Kenichi Kawahori, Nozomi Hanzawa, Miho Hamaguchi, Takami Seki, Makiko Nawa, Tatsuya Ehara, Yohei Kitamura, Izuho Hatada, Morichika Konishi, Nobuyuki Itoh, Yoshimi Nakagawa, Hitoshi Shimano, Takako Takai-Igarashi, Yasutomi Kamei, Yoshihiro Ogawa
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
FGF21 exerts beneficial metabolic effects on multiple tissues. Here the authors show that the Fgf21 gene is demethylated during the postnatal suckling period, creating an epigenetic memory that determines the responsiveness of the Fgf21 gene to induc
Externí odkaz:
https://doaj.org/article/c62f55c79e3144f582a03839a050d571
Publikováno v:
Data in Brief, Vol 23, Iss , Pp - (2019)
PGC-1β is a transcriptional co-activator of nuclear receptors, which acts to increase energy expenditure. PGC-1β fused to GAL4 DNA-binding domain transfected in HEK293T cells showed a reporter luciferase activity. We screened food-derived and natur
Externí odkaz:
https://doaj.org/article/5bbc449fbc9d409281f5bb4f1fb3ef41
Publikováno v:
Nutrients, Vol 13, Iss 2, p 497 (2021)
Peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) is expressed in skeletal muscles and regulates systemic metabolism. Thus, nutraceuticals targeting skeletal muscle PGC-1α have attracted attention to modulate systemic metabolis
Externí odkaz:
https://doaj.org/article/fa7ca846feb749ed8f24005f0760edde
Publikováno v:
Nutrients, Vol 12, Iss 10, p 3189 (2020)
Skeletal muscle, the largest organ in the human body, accounting for approximately 40% of body weight, plays important roles in exercise and energy expenditure. In the elderly, there is often a progressive decline in skeletal muscle mass and function
Externí odkaz:
https://doaj.org/article/a4ce95ab424044bfa95b874b1636e89e
Autor:
Nanami Senoo, Noriyuki Miyoshi, Naoko Goto-Inoue, Kimiko Minami, Ryoji Yoshimura, Akihito Morita, Naoki Sawada, Junichiro Matsuda, Yoshihiro Ogawa, Mitsutoshi Setou, Yasutomi Kamei, Shinji Miura
Publikováno v:
Journal of Lipid Research, Vol 56, Iss 12, Pp 2286-2296 (2015)
Exercise training influences phospholipid fatty acid composition in skeletal muscle and these changes are associated with physiological phenotypes; however, the molecular mechanism of this influence on compositional changes is poorly understood. Pero
Externí odkaz:
https://doaj.org/article/6bacb172fa7f453d802046963466b705