Výsledky vyhledávání - "Yasuto Morimoto"

Synthesis and Biological Activities of Optical Isomers of 2-(4-Chlorophenyl)-5,6-dihydro-(1)benzothiepino(5,4-c)pyridazin-3(2H)-one 7-Oxide

Autor: Yasuto Morimoto, Kuniki Ikeda, Tohru Nakao, Nobuhiro Marubayashi, Yuko Yamaguchi, Minoru Obata

Publikováno v: Chemical and Pharmaceutical Bulletin. 40:117-121

Two enantiomers of 2-(4-chlorophenyl)-5,6-dihydro-(1)benzothiepino[5,4- c]pyridazin-3(2H)-one 7-oxide ((+/-)-1: Y-23684) were synthesized in high yields by asymmetric oxidation of the synthetic precursor (2) using modified Sharpless reagent. Among th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3b618a4ab9a518fd8aacd820a3ef521
https://doi.org/10.1248/cpb.40.117

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Studies on the Synthesis of Condensed Pyridazine Derivatives. IV. Synthesis and Anxiolytic Activity of 2-Aryl-5,6-dihydro-(1)benzothiepino(5,4-c)pyridazin-3(2H)-ones and Related Compound

Autor: Yasuto Morimoto, Tohru Nakao, Minoru Obata, Takashi Yakushiji, Tetsuya Tahara, Kenji Morita, Hiroshi Tanaka, Shuzo Takehara, Minoru Kawakami

Publikováno v: Chemical and Pharmaceutical Bulletin. 39:2556-2563

A series of 2-aryl-5,6-dihydro-(1)benzothiepino[5,4-c]pyridazin-3(2H)- ones and related compounds were synthesized and evaluated for their ability to displace 3H-diazepam from rat brain membranes in vitro, and to prevent bicuculline induced convulsio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4de53589b3f90e30034237e7a3b2757
https://doi.org/10.1248/cpb.39.2556

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Studies on the Synthesis of Condensed Pyridazine Derivatives. III. Synthesis and Benzodiazepine Receptor Binding Studies of Condensed Triazolopyridazine Derivatives

Autor: Yasuto Morimoto, Tetsuya Tahara, Kenichi Demizu, Hiroshi Tanaka, Shuzo Takehara, Tohru Nakao

Publikováno v: YAKUGAKU ZASSHI. 110:922-931

A series of 6H-(1)benzothiopyrano[3,4-e][1,2,4]triazolo[4,3- b]pyridazines and 6,7-dihydro-(1)benzothiepino[4,5- e][1,2,4]triazolo [4,3-b]pyridazines were prepared and tested for their ability to displace [3H] diazepam from rat brain membranes. An ap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4584637d484607eeb6495e59553d5a89
https://doi.org/10.1248/yakushi1947.110.12_922

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Effect of Y-516 on the hyperactivity induced by dopamine injected bilaterally into the nucleus accumbens

Autor: Michihide Setoguchi, Takemi Fukuda, Toshihiko Morimoto, Yasuto Morimoto

Publikováno v: Folia Pharmacologica Japonica. 96:65-71

The effect of Y-516 on the hyperactivity induced by dopamine injected bilaterally into the nucleus accumbens was compared with those of clocapramine (CCP), haloperidol (HPD) and chlorpromazine (CPZ). Dopamine (5-50 micrograms) injected into the nucle

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1735eea68aca0482ab6fbeeb6f1a3bc
https://doi.org/10.1254/fpj.96.2_65

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The pharmacological properties of Y-23684, a benzodiazepine receptor partial agonist

Autor: Yasuto Morimoto, Michihide Setoguchi, Hiroshi Yasumatsu, Shuzo Takehara, Yoshinobu Yamamoto, Tohru Nakao, Takemi Fukuda

Publikováno v: British journal of pharmacology. 111(4)

1. The pharmacological properties of a benzodiazepine receptor (BZR) partial agonist, Y-23684 were investigated in comparison with those of diazepam, a conventional BZR full agonist. 2. Y-23684 and diazepam showed high and selective affinity for the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ceda443978299fcc65c0dc4e364c5ceb
https://pubmed.ncbi.nlm.nih.gov/7913372

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Characterization of the currents induced by sigma ligands in NCB20 neuroblastoma cells

Autor: Hayato Tanimoto, Yasuto Morimoto, Yasunori Morio, Takashi Yakushiji

Publikováno v: Brain research. 637(1-2)

Electrical and pharmacological properties of currents induced by compounds having affinities for putative sigma receptors were investigated with NCB20 cells by use of the whole-cell patch-clamp technique. Antipsychotics and naloxone induced inward cu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fbe4e1d7513b10b71cd0a13a8aa9151
https://pubmed.ncbi.nlm.nih.gov/7910100

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The effects of orally administered Y-25130, a selective serotonin3-receptor antagonist, on chemotherapeutic agent-induced emesis

Autor: Hidenori Shoji, Takemi Fukuda, Keiichiro Haga, Michihide Setoguchi, Ken-ichi Inaba, Yasuto Morimoto

Publikováno v: Japanese journal of pharmacology. 63(3)

The antiemetic effects of orally administered Y-25130, a potent and selective 5-HT3-receptor antagonist, were compared with those of ondansetron, granisetron, metoclopramide and domperidone. Y-25130 (0.1-1.0 mg/kg) dose-dependently prolonged the late

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::078188d34519756c6b38edb8134eaf23
https://pubmed.ncbi.nlm.nih.gov/8107329

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[Studies on the synthesis of condensed pyridazine derivatives. II. Synthesis and anxiolytic activities of 2-aryl-4,4a,5,6-tetrahydropyridazino[4,3-c]quinolin-3(2H)-ones, 2-aryl-4a,5-dihydro-2H-(1)benzothiopyrano[4,3-c]pyridazin-3(4H)-ones, and related compounds]

Autor: Tetsuya Tahara, Tohru Nakao, Kenji Morita, Minoru Kawakami, Yasuto Morimoto, Minoru Obata, Shuzo Takehara

Publikováno v: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 110(8)

A series of 2-aryl-4,4a,5,6-tetrahydropyridazino[4,3-c]quinolin-3(2H)- ones, 2-aryl-4a,5-dihydro-2H-(1)benzothiopyrano[4,3-c]pyridazin-3( 4H)-ones, and related compounds were synthesized and tested for their ability to displace [3H]diazepam from rat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88b6f5fb43dd72769aea1eb3011b09a2
https://pubmed.ncbi.nlm.nih.gov/1980306

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[Studies on the synthesis of condensed pyridazine derivatives. I. Synthesis and benzodiazepine receptor binding studies of 2-substituted-4,4a,5,6-tetrahydrobenzo[h]cinnolin-3(2H)-ones and related compounds]

Autor: Kenji Morita, Tetsuya Tahara, Tohru Nakao, Shuzo Takehara, Minoru Kawakami, Yasuto Morimoto

Publikováno v: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 110(8)

A series of 2-substituted-4,4a,5,6-tetrahydrobenzo[h]cinnolin-3(2H)-ones and related compounds were synthesized and tested for their ability to displace [3H]diazepam from rat brain membranes. Among them, compounds bearing 4-methoxyphenyl, 4-chlorophe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e86ad00903c69b3f705a5108b3cd30e8
https://pubmed.ncbi.nlm.nih.gov/1980305

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