Zobrazeno 1 - 10
of 278
pro vyhledávání: '"Yasuto, Akiyama"'
Autor:
Takeshi Nagashima, Ken Yamaguchi, Kenichi Urakami, Yuji Shimoda, Sumiko Ohnami, Keiichi Ohshima, Tomoe Tanabe, Akane Naruoka, Fukumi Kamada, Masakuni Serizawa, Keiichi Hatakeyama, Shumpei Ohnami, Koji Maruyama, Tohru Mochizuki, Maki Mizuguchi, Akio Shiomi, Yasuhisa Ohde, Etsuro Bando, Teiichi Sugiura, Takashi Mukaigawa, Seiichiro Nishimura, Yasuyuki Hirashima, Koichi Mitsuya, Shusuke Yoshikawa, Yoshio Kiyohara, Yasuhiro Tsubosa, Hirohisa Katagiri, Masashi Niwakawa, Kaoru Takahashi, Hiroya Kashiwagi, Yoshichika Yasunaga, Yuji Ishida, Takashi Sugino, Hirotsugu Kenmotsu, Masanori Terashima, Mitsuru Takahashi, Katsuhiko Uesaka, Yasuto Akiyama
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract In cancer genome analysis, identifying pathogenic alterations and assessing their effects on oncogenic processes is important. Although whole exome sequencing (WES) can effectively detect such changes, driver alterations could not be identif
Externí odkaz:
https://doaj.org/article/78e02debd67d4858aa07bf66640f5372
Autor:
Keiichi Hatakeyama, Koji Muramatsu, Takeshi Nagashima, Hiroyuki Ichida, Yuichi Kawanishi, Ryutaro Fukumura, Keiichi Ohshima, Yuji Shimoda, Sumiko Ohnami, Shumpei Ohnami, Koji Maruyama, Akane Naruoka, Hirotsugu Kenmotsu, Kenichi Urakami, Yasuto Akiyama, Takashi Sugino, Ken Yamaguchi
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-8 (2024)
Abstract The detection of copy number variations (CNVs) and somatic mutations in cancer is important for the selection of specific drugs for patients with cancer. In cancers with sporadic tumor cells, low tumor content prevents the accurate detection
Externí odkaz:
https://doaj.org/article/3803f9f730f74fb287285c07c11200a5
Autor:
Masanori Nakamura, Yukiyasu Okamura, Keiichi Ohshima, Teiichi Sugiura, Ryo Ashida, Katsuhisa Ohgi, Etsuro Bando, Keiichi Fujiya, Akio Shiomi, Hiroyasu Kagawa, Taisuke Imamura, Goro Nakayama, Yasuhiro Kodera, Katsuhiko Uesaka, Nobuyuki Ohike, Tomoko Norose, Keiko Sasaki, Takashi Sugino, Sumiko Ohnami, Takeshi Nagashima, Kenichi Urakami, Yasuto Akiyama, Ken Yamaguchi
Publikováno v:
Cancer Medicine, Vol 12, Iss 10, Pp 11491-11502 (2023)
Abstract Background Small intestine carcinoma (SIC) cases in Japan have recently been treated with chemotherapy according to colorectal carcinoma classification, while papilla of Vater carcinoma (PVC) cases according to cholangiocarcinoma (CHC) class
Externí odkaz:
https://doaj.org/article/90fe44a7d8d54390a3170b7b4a8224c9
Autor:
Taisuke Imamura, Ryo Ashida, Keiichi Ohshima, Katsuhiko Uesaka, Teiichi Sugiura, Katsuhisa Ohgi, Mihoko Yamada, Shimpei Otsuka, Keiichi Hatakeyama, Takeshi Nagashima, Takashi Sugino, Kenichi Urakami, Yasuto Akiyama, Ken Yamaguchi
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract In pancreatic cancer (PC), Tumor mutation burden (TMB) has been reported to be lower than in other cancers, with its clinical significance remaining unclear. We analyzed the dataset of whole-exome sequencing and gene expression profiling of
Externí odkaz:
https://doaj.org/article/185d8dbe29404cfab80d48a8d53a6de5
Autor:
Taisuke Imamura, Yukiyasu Okamura, Keiichi Ohshima, Katsuhiko Uesaka, Teiichi Sugiura, Takaaki Ito, Yusuke Yamamoto, Ryo Ashida, Katsuhisa Ohgi, Shimpei Otsuka, Sumiko Ohnami, Takeshi Nagashima, Keiichi Hatakeyama, Takashi Sugino, Kenichi Urakami, Yasuto Akiyama, Ken Yamaguchi
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-12 (2022)
Abstract Background Multiple mutation (MM) within a single gene has recently been reported as a mechanism involved in carcinogenesis. The present study investigated the clinical significance of MMs in hepatocellular carcinoma (HCC). Methods Two hundr
Externí odkaz:
https://doaj.org/article/a9e551d267724b08a56b352494c5a412
Autor:
Sumiko Ohnami, Akane Naruoka, Mitsuhiro Isaka, Maki Mizuguchi, Sou Nakatani, Fukumi Kamada, Yuji Shimoda, Ai Sakai, Keiichi Ohshima, Keiichi Hatakeyama, Kouji Maruyama, Yasuhisa Ohde, Hirotsugu Kenmotsu, Toshiaki Takahashi, Yasuto Akiyama, Takeshi Nagashima, Kenichi Urakami, Shumpei Ohnami, Ken Yamaguchi
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract The differences in genetic susceptibility to lung adenocarcinoma and squamous cell carcinoma remain unclear. We developed a customized, targeted gene sequencing panel for efficient and sensitive identification of germline variants, including
Externí odkaz:
https://doaj.org/article/2f07bf26841c4645bc84e2251e27d091
Autor:
Taisuke Imamura, Yukiyasu Okamura, Keiichi Ohshima, Katsuhiko Uesaka, Teiichi Sugiura, Takaaki Ito, Yusuke Yamamoto, Ryo Ashida, Katsuhisa Ohgi, Shimpei Otsuka, Sumiko Ohnami, Takeshi Nagashima, Keiichi Hatakeyama, Yuko Kakuda, Takashi Sugino, Kenichi Urakami, Yasuto Akiyama, Ken Yamaguchi
Publikováno v:
Cancer Medicine, Vol 11, Iss 8, Pp 1769-1786 (2022)
Abstract Introduction The genomic characteristics of hepatocellular carcinoma (HCC) after a sustained virological response (SVR) and its differences according to whether an SVR was achieved by treatment with direct‐acting antivirals (DAA) or interf
Externí odkaz:
https://doaj.org/article/cda7410014fc4f75b329364b7e281b20
Autor:
Keiichi Hatakeyama, Koji Muramatsu, Takeshi Nagashima, Yuichi Kawanishi, Ryutaro Fukumura, Keiichi Ohshima, Yuji Shimoda, Hirotsugu Kenmotsu, Tohru Mochizuki, Kenichi Urakami, Yasuto Akiyama, Takashi Sugino, Ken Yamaguchi
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-8 (2022)
Abstract Targeted sequencing offers an opportunity to select specific drugs for cancer patients based on alterations in their genome. However, accurate sequencing cannot be performed in cancers harboring diffuse tumor cells because of low tumor conte
Externí odkaz:
https://doaj.org/article/6695e80cba474b6392ca70861efa1b00
Autor:
AKIRA IIZUKA1 a.iizuka@scchr.jp, YASUTO AKIYAMA1, NAOKI SAKURA2, AKARI KANEMATSU1, YASUFUMI KIKUCHI1, TAKESHI NAGASHIMA3,4, KENICHI URAKAMI3, YUJI SHIMODA3, KEIICHI OHSHIMA2, AKIO SHIOMI5, YASUHISA OHDE6, MASANORI TERASHIMA7, KATSUHIKO UESAKA8, TAKASHI MUKAIGAWA9, YASUYUKI HIRASHIMA10, SHUSUKE YOSHIKAWA11, HIROHISA KATAGIRI12, TAKASHI SUGINO13, MITSURU TAKAHASHI12, HIROTSUGU KENMOTSU14
Publikováno v:
Oncology Letters. Aug2023, Vol. 26 Issue 2, p1-11. 11p.
Autor:
Masakuni Serizawa, Maki Mizuguchi, Kenichi Urakami, Takeshi Nagashima, Keiichi Ohshima, Keiichi Hatakeyama, Sumiko Ohnami, Shumpei Ohnami, Koji Maruyama, Tadashi Ashizawa, Akira Iizuka, Yasue Horiuchi, Akane Naruoka, Hirotsugu Kenmotsu, Yasuto Akiyama, Ken Yamaguchi
Publikováno v:
Human Genome Variation, Vol 8, Iss 1, Pp 1-4 (2021)
Abstract With the emergence of next-generation sequencing (NGS)-based cancer gene panel tests in routine oncological practice in Japan, an easily interpretable cancer genome database of Japanese patients in which mutational profiles are unaffected by
Externí odkaz:
https://doaj.org/article/8a42780e28d84ad0ab5763fa21a3172d