Výsledky vyhledávání - "Yasuteru Sakamoto"

Akademický článek

Genomic integration of lambda EG10 transgene in gpt delta transgenic rodents.

Autor: Kenichi Masumura¹ masumura@nihs.go.jp, Yasuteru Sakamoto^1,2, Wakako Kumita¹, Masamitsu Honma¹, Akiyoshi Nishikawa³, Takehiko Nohmi^1,3

Publikováno v: Genes & Environment. 12/1/2015, Vol. 37, p1-13. 13p.

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Involvement of mismatch repair proteins in adaptive responses induced by N-methyl-N′-nitro-N-nitrosoguanidine against γ-induced genotoxicity in human cells

Autor: Ayumi Yamamoto, Kenichi Masumura, Masamitsu Honma, Takehiko Nohmi, Yasuteru Sakamoto

Publikováno v: Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 713:56-63

As humans are exposed to a variety of chemical agents as well as radiation, health effects of radiation should be evaluated in combination with chemicals. To explore combined genotoxic effects of radiation and chemicals, we examined modulating effect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b76228e96da5c4e846e1713b151a5483
https://doi.org/10.1016/j.mrfmmm.2011.05.014

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Antigenotoxic effects of p53 on spontaneous and ultraviolet light B-induced deletions in the epidermis of gpt delta transgenic mice

Autor: Kenichi Masumura, Takashi Umemura, Akiyoshi Nishikawa, Yasuo Asami, Tetsuya Ono, Yasuteru Sakamoto, Masae Tatematsu, Yuichi Kuroiwa, Megumi Ikeda, Hironobu Ikehata, Takehiko Nohmi, Tetsuya Tsukamoto

Publikováno v: Environmental and Molecular Mutagenesis. 52:244-252

Tumor development in the skin may be a multistep process where multiple genetic alterations occur successively. The p53 gene is involved in genome stability and thus is referred to as “the guardian of the genome.” To better understand the antigen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::335979eac6d6e838e1c1e4b87a54f1c9
https://doi.org/10.1002/em.20610

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Combined genotoxic effects of radiation and a tobacco-specific nitrosamine in the lung of gpt delta transgenic mice

Autor: Isamu Hayata, Mitsuru Nenoi, Keiko Sakuma, Yasuteru Sakamoto, Bing Wang, Takehiko Nohmi, Megumi Ikeda, Kenichi Masumura

Publikováno v: Genetic Toxicology and Environmental Mutagenesis : A Section of Mutation Research. 626(1/2):15-25

It is important to evaluate the health effects of low-dose-rate or low-dose radiation in combination with chemicals as humans are exposed to a variety of chemical agents. Here, we examined combined genotoxic effects of low-dose-rate radiation and 4-(

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49088e83e9781a3655526b38a240f9ef
https://repo.qst.go.jp/records/44821

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Genomic integration of lambda EG10 transgene in gpt delta transgenic rodents

Autor: Wakako Kumita, Kenichi Masumura, Takehiko Nohmi, Masamitsu Honma, Yasuteru Sakamoto, Akiyoshi Nishikawa

Publikováno v: Genes and Environment

Background Transgenic gpt delta mouse and rat models were developed to perform gpt and Spi− assays for in vivo mutagenicity tests. The animals were established by integration of lambda EG10 phage DNA as a transgene into the genome. The inserted pos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5756e7242f64f5d48705031de600924
https://doi.org/10.1186/s41021-015-0024-6

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Additional file 4: Fig. S4. of Genomic integration of lambda EG10 transgene in gpt delta transgenic rodents

Autor: Masumura, Kenichi, Yasuteru Sakamoto, Kumita, Wakako, Honma, Masamitsu, Nishikawa, Akiyoshi, Nohmi, Takehiko

PCR analysis of the type of junctions between lambda EG10 copies. PCR primers were set at both ends of lambda EG10 to amplify the connecting region of two EG10 copies. The genomic DNA of gpt delta mice and rats was used as the PCR template. PCR was p

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Additional file 1: Fig. S1. of Genomic integration of lambda EG10 transgene in gpt delta transgenic rodents

Autor: Masumura, Kenichi, Yasuteru Sakamoto, Kumita, Wakako, Honma, Masamitsu, Nishikawa, Akiyoshi, Nohmi, Takehiko

Mapping of the mate pairs (MPs) covering the junctions of EG10 copies in gpt delta mice. Each MP has two sequenced positions (F and R reads). The sequenced reads were categorized as 4 types: F+, F position read EG10 sequence in plus direction; F−,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33dd107bf2fb6ff6c3ebb2d6afb35a29

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