Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Yasutaka Ohta"'
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract The mechanistic target of rapamycin (mTOR) is a serine/threonine protein kinase that forms the two different protein complexes, known as mTORC1 and mTORC2. mTOR signaling is activated in a variety of tumors, including glioma that is one of t
Externí odkaz:
https://doaj.org/article/564101e2b5e94234bb9b80f5879ed4a3
Autor:
Koji Saito, Sakino Ozawa, Yosuke Chiba, Ruri Takahashi, Ryoya Ogomori, Kojiro Mukai, Tomohiko Taguchi, Hiroyasu Hatakeyama, Yasutaka Ohta
Publikováno v:
Cell Structure and Function, Vol 48, Iss 2, Pp 161-174 (2023)
Invadopodia are protrusive structures that mediate the extracellular matrix (ECM) degradation required for tumor invasion and metastasis. Rho small GTPases regulate invadopodia formation, but the molecular mechanisms of how Rho small GTPase activitie
Externí odkaz:
https://doaj.org/article/96f940d7a0ec4d6eb66092a8c3263bfc
Autor:
Hazuki Yamada, Koji Tsutsumi, Yuki Nakazawa, Yoshio Shibagaki, Seisuke Hattori, Yasutaka Ohta
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0146593 (2016)
FilGAP is a Rac-specific GTPase-activating protein (GAP) that suppresses lamellae formation. In this study, we have identified RBM10 (RNA Binding Motif domain protein 10) as a FilGAP-interacting protein. Although RBM10 is mostly localized in the nucl
Externí odkaz:
https://doaj.org/article/62d6ed7f37174709a99d0ab4fd56feab
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e100271 (2014)
Rho small GTPases control cell morphology and motility through the rearrangement of actin cytoskeleton. We have previously shown that FilGAP, a Rac-specific GAP, binds to the actin-cross-linking protein Filamin A (FLNa) and suppresses Rac-dependent l
Externí odkaz:
https://doaj.org/article/f16a2e0a47344119923fd8e9530705dc
Autor:
Koji Saito, Seiji Yokawa, Hidetake Kurihara, Eishin Yaoita, Sari Mizuta, Kanae Tada, Moemi Oda, Hiroyasu Hatakeyama, Yasutaka Ohta
Publikováno v:
FASEB Journal; 3/15/2024, Vol. 38 Issue 5, p1-19, 19p
Autor:
Naozumi Kondo, Aoi Kimishima, Serino Maruyama, Mai Sato, Hidetaka Yuge, Yasutaka Ohta, David Mota-Sanchez, John C. Wise, Yoshihiro Watanabe, Kazunari Sakai, Masato Iwatsuki, Yukihiro Asami
Publikováno v:
ACS Agricultural Science & Technology. 3:278-286
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::504ad2295e47dde16943e3ae5ebdd067
https://doi.org/10.1021/acsagscitech.2c00293
https://doi.org/10.1021/acsagscitech.2c00293
Endosomal Localization of RacGAP Protein ARHGAP22 Regulates its GAP Activity in Human Melanoma Cells
Publikováno v:
Anticancer Research. 42:5763-5771
Rho small GTPases regulate cancer cell adhesion, migration and invasion through reorganization of the actin cytoskeleton. Rho GTPase Activating Protein 22 (ARHGAP22) is a Rac-specific GAP and suppresses Rac-dependent lamella formation and cell spread
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::516d560064aa4e0ef01359243b9bab67
https://doi.org/10.21873/anticanres.16083
https://doi.org/10.21873/anticanres.16083
Autor:
Koji Saito, Shiori Tamura, Shigeki Kato, Mizuki Wakabayashi, Satoko Kanzaki, Yasutaka Ohta, Toshiaki Ito, Yoichi Sekita, Tohru Kimura
Publikováno v:
Reproduction. 160:181-191
Nucleotide-binding oligomerization domain, leucine-rich repeat and pyrin domain-containing proteins (NRLPs) are central components of the inflammasome. Accumulating evidence has shown that a reproductive clade of NRLPs is predominantly expressed in o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3990d5723583297de8236a100772748f
https://doi.org/10.1530/rep-19-0516
https://doi.org/10.1530/rep-19-0516
Publikováno v:
The FASEB Journal. 35
Migrating tumor cells are characterized by a sustained front-rear asymmetry, with a front enriched in filamentous actin, which is induced by Rho small GTPase Rac. Regulation of Rac activity by its regulators should be required for effective motility.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ed4f48a026dd2caed070b184ea163e1
https://doi.org/10.1096/fj.202002155r
https://doi.org/10.1096/fj.202002155r
Autor:
Koji Tsutsumi, Yoh Nakamura, Yasutaka Ohta, Yusuke Kitagawa, Yurina Suzuki, Yoshio Shibagaki, Seisuke Hattori
Publikováno v:
Biochemical and biophysical research communications. 522(3)
The Arf (ADP-ribosylation factor) GAPs (GTPase-activating proteins) regulate membrane trafficking and actin cytoskeleton. The molecular mechanism of how Arf GAPs regulate actin cytoskeleton remains to be elucidated. We identified AGAP1, a subtype of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58bb4862f496f07d504d9035fa0cd6fe
https://pubmed.ncbi.nlm.nih.gov/31785816
https://pubmed.ncbi.nlm.nih.gov/31785816