Zobrazeno 1 - 10 of 30 pro vyhledávání: '"Yasutaka Kayama"'
1
Diazepines. 5. Synthesis and biological action of 6-phenyl-4H-pyrrolo[1,2-a][1,4]benzodiazepines
Autor: Takeshi Hara, Ishimoto Sachio, Toshiro Mori, Yoshinobu Hashimoto, Sunami Tamiko, Kazuhiko Itoh, Yasutaka Kayama, Fujimori Hitoshi
Publikováno v: Journal of Medicinal Chemistry. 21:263-268
A series of 6-phenyl-4H-pyrrolo[1,2-a][1,4]benzodiazepines (2) has been prepared with 2-phthalimidomethylfurans (12) and 1-phthalimidoalkane-2,5-diones (15) or 2,5-dimethoxy-2-phthalimidomethyltetrahydrofurans (16) as the key intermediates and subseq
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efd801e15e469269d7b8164b7ef84006
https://doi.org/10.1021/jm00201a005
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2
SYNTHESIS AND PHOTOCHEMISTRY OF 2-CYCLOOCTENE-1,4-DIONE
Autor: Yasutaka Kayama, Yoshio Kitahapa, Masaji Oda
Publikováno v: Chemistry Letters. 3:345-348
cis-2-Cyclooctene-1,4-dione 1 is prepared starting from 1,3-cyclooctadiene. Photoirradiation of 1 in ether gives a [π2s+2a] dimer, while irradiations in the presence of cyclic dienes give trans- [2+4]cycloadducts. The intermediacy of trans-2-cyclooc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c4bedbc28d842d29a1e02b3e3d7002fa
https://doi.org/10.1246/cl.1974.345
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3
Diazepines. IV. Synthesis and biological action of 6-phenyl-4H-imidazo[1,2-a][1,5]benzodiazepin-5(6H)-ones
Autor: Takeshi Hara, Yoshinobu Hashimoto, Toshiro Mori, Fujimori Hitoshi, Yasutaka Kayama, Kazuhiko Itoh
Publikováno v: Chemical and Pharmaceutical Bulletin. 25:2584-2592
A series of 6-phenyl-4H-imidazo [1, 2-α] [1, 5] benzodiazepin-5 (6H)-ones (1) was synthesized starting from 2-nitrodiphenylamines (9) and was evaluated for CNS activity. Bromoacetylation of 9 to N-bromoacetyl-2-nitrodiphenylamines (10) and subsequen
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::865e4bee961feeb19fcc189d0e44d80d
https://doi.org/10.1248/cpb.25.2584
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4
Cyclic isothioureido compounds. II. Reaction oftrans-3a,4,5,9b-tetrahydronaphth[1,2-d]-imidazoline-2-thiones with α-bromoketones
Autor: Takeshi Hara, Hisashi Fukushima, Yasutaka Kayama
Publikováno v: Journal of Heterocyclic Chemistry. 18:1089-1093
The reaction of trans-3a,4,5,9b-tetrahydronaphth[1,2-d]imidazoline-2-thiones (8) with α-bromoketones gave, depending upon the structure of the α-bromoketones, reaction solvent and reaction temperature, the hydrobromides of tetrahydronaphth[1,2-d]im
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2777ccc9b3b6a1895753fbd01bbabc8a
https://doi.org/10.1002/jhet.5570180606
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5
AN INTRAMOLECULARC-ACYLATION OF AN ENOL: PHOTOCHEMICAL REARRANGEMENT OF TRICYCLO[3.3.2.02,4]DECA-6,9-DIEN-8-ON-1-OL
Autor: Yoshio Kitahara, Tadao Uyehara, M. Taniguchi, Yasutaka Kayama, Chizuko Kabuto
Publikováno v: Chemistry Letters. 6:569-572
Under direct irradiation in methanol, the compound in the title (6) gave tricyclic keto-ester 7. In the presence of acetic acid, 6 in methanol gave tetracyclo[5.3.01,7.02,10.03,5]deca-6,8-dione (8), which underwent futher photochemical change to mono
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c47c74209a80c39257c1a43ab01fdacb
https://doi.org/10.1246/cl.1977.569
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7
A NEW SYNTHESIS AND THERMAL REARRANGEMENT OF 3,4-BENZOBICYCLO[4.2.0]OCTA-3,7-DIENE-2,5-DIONE
Autor: Hideo Miyazaki, Yasutaka Kayama, Yoshio Kitahara, Masaji Oda
Publikováno v: Chemistry Letters. 4:627-630
Title compound (3) was prepared by a new method from bicyclo[4.2.0]octa-3,7-diene-2,5-dione through Diels-Alder reaction with butadiene, bromination with NBS, and then dehydrobromination with triethylamine. Thermolysis of (3) at 500°C gave, unexpect
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ad2123e66c108c528e8f03e50f534b59
https://doi.org/10.1246/cl.1975.627
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8
A novel method of conjugation of daunomycin with antibody with a poly(L-glutamic acid) derivative as intermediate drug carrier. An anti-.alpha.-fetoprotein antibody-daunomycin conjugate
Autor: Naoji Umemoto, Takeshi Hara, Hisashi Fukushima, Yumiko Takeda, Yoshinori Kato, Yasutaka Kayama, Yutaka Tsukada
Publikováno v: Journal of Medicinal Chemistry. 27:1602-1607
In studies on antitumor antibody-cytotoxic drug conjugates as potential antitumor agents with improved tumor specificity, daunomycin (DM) was first linked to a poly-L-glutamic acid (PLGA) derivative having a single masked thiol group. At the thiol gr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04792552f66069ad83468f47974adeb1
https://doi.org/10.1021/jm00378a013
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10
Diazepines. III. Synthesis of 4H-Pyrrolo[1,2-a] thieno[3,2-f] [1,4] diazepines
Autor: Sunami Tamiko, Kazuhiko Itoh, Hitoxhi Fujimori, Yasutaka Kayama, Takeshi Hara
Publikováno v: Journal of Heterocyclic Chemistry. 14:235-240
The synthesis of 4H-pyrrolo[1,2-a]thieno[3,2-f] [1,4]diazepines (8) is described. Phthal-imidomethylfurans 1 were treated with bromine-methanol to give the dihydrofurans 2, which were hydrolyzed and then liydrogenated over Raney nickel or with zinc-a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b2111f037e2d432fb0bcaaeb511b1ffd
https://doi.org/10.1002/jhet.5570140214
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