Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Yasutaka Igari"'
Publikováno v:
YAKUGAKU ZASSHI. 134:203-211
Global spread of counterfeit medicines is an imminent threat for the patients' safety. Although major targets of counterfeits are still erectile dysfunction (ED) drugs in the industrialized countries, including Japan, anti-cancer agents and some medi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82bad390fb547ff3986e86bc3ec27629
https://doi.org/10.1248/yakushi.13-00230-2
https://doi.org/10.1248/yakushi.13-00230-2
Autor:
Yasutaka Igari, Tetsuro Tabata, Toshihiro Shimizu, Shuji Morimoto, Yoshinori Nakano, Naoru Hamaguchi
Publikováno v:
Chemical and Pharmaceutical Bulletin. 51:942-947
Lansoprazole fast-disintegrating tablet (LFDT) is a new patient-friendly formulation of lansoprazole. Since lansoprazole is an antiulcer agent and is unstable under acidic conditions, we have developed LFDT as an orally disintegrating tablet containi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bb1d19943beefd5408214be0b348d5a
https://doi.org/10.1248/cpb.51.942
https://doi.org/10.1248/cpb.51.942
Autor:
Masae Sugaya, Toshihiro Shimizu, Daisuke Izutsu, Yoshio Mizukami, Naoru Hamaguchi, Kazuhiro Okochi, Yoshinori Nakano, Tetsuro Tabata, Yasutaka Igari
Publikováno v:
Chemical and Pharmaceutical Bulletin. 51:1121-1127
Lansoprazole fast-disintegrating tablets (LFDT) are a patient-friendly formulation that rapidly disintegrates in the mouth. LFDT consist of enteric-coated microgranules (mean particle size, approximately 300 microm) and inactive granules. In the desi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::628b1030c5c0378307d7375d2b1ed35f
https://doi.org/10.1248/cpb.51.1121
https://doi.org/10.1248/cpb.51.1121
Publikováno v:
Journal of Controlled Release. 40:269-276
Release of leuprorelin, an LHRH agonist, from injectable microcapsules and degradation of its biodegradable polymer [( d,l -lactic-glycolic) acid copolymer: PLGA] matrix were investigated to optimize an in vitro release test system and to clarify the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::69f4ad84416d098ff52b1a867a94f625
https://doi.org/10.1016/0168-3659(95)00194-8
https://doi.org/10.1016/0168-3659(95)00194-8
Publikováno v:
Drug Delivery System. 8:237-241
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::980f588e57d4763892016bd7a45352dc
https://doi.org/10.2745/dds.8.237
https://doi.org/10.2745/dds.8.237
Publikováno v:
The FASEB Journal. 4:2533-2539
A system for the delayed or pulsed release of biologically active substances was achieved by encapsulating liposomes containing the substance of interest inside microcapsules. The microcapsules retain the liposomes but allow controlled diffusion of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd18bd8b6658c8ea6731ca802571ebc7
https://doi.org/10.1096/fasebj.4.8.2110539
https://doi.org/10.1096/fasebj.4.8.2110539
Autor:
Toshihiro Shimizu, Tetsuro Tabata, Hiroshi Iki, Naoru Hamaguchi, Yasutaka Igari, Norio Kameoka
Publikováno v:
Chemicalpharmaceutical bulletin. 51(9)
The purpose of this study was to develop enteric-coated microgranules for the lansoprazole fast-disintegrating tablet (LFDT), which is a rapidly disintegrating tablet containing enteric-coated microgranules. In our previous study, it was clarified th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6eec739d64d9bffebd37775fcd94676c
https://pubmed.ncbi.nlm.nih.gov/12951443
https://pubmed.ncbi.nlm.nih.gov/12951443
Autor:
Yasutaka Igari, Yumi Yuasa, Kayoko Okamoto, Yasuaki Ogawa, Yutaka Yamagata, Katsumi Iga, Kazumichi Yamamoto
Publikováno v:
Journal of interferoncytokine research : the official journal of the International Society for Interferon and Cytokine Research. 20(2)
The objective of this study was to assess the pharmacologic effect of continuously released recombinant human interferon-alpha (rHuIFN-alpha) in the liver, the target organ of chronic hepatitis B and C, using 2',5'-oligoadenylate synthetase (2',5'-OA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::789f2ac932b13c4f492d6c8e3a00d595
https://pubmed.ncbi.nlm.nih.gov/10714550
https://pubmed.ncbi.nlm.nih.gov/10714550
Autor:
Tsugio Shimamoto, Katsumi Iga, Yasutaka Igari, Hajime Toguchi, Yasuaki Ogawa, Naoru Hamaguchi
Publikováno v:
Journal of pharmaceutical sciences. 80(6)
Hyperthermia (HT)-dependent cisplatin (CDDP) release and tumor CDDP level increase after the administration of thermosensitive, large unilamellar vesicles (LUVs: LUV-1 and LUV-2) and a thermosensitive, small unilamellar vesicle (SUV: SUV-1) were exam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3330f3c4aea5360c67a7e8cb949ec7f
https://pubmed.ncbi.nlm.nih.gov/1941540
https://pubmed.ncbi.nlm.nih.gov/1941540
Publikováno v:
Journal of Pharmacokinetics and Biopharmaceutics. 10:53-75
A physiologically based pharmacokinetic model, which is an extension of the Bischoff-Dedrick multiorgan model, was developed to described the kinetics of barbiturates (hexobarbital, phenobarbital, and thiopental) in the rat. The model is composed of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4956fe4856e9fd226d4fa0e5b3d5878e
https://doi.org/10.1007/bf01059183
https://doi.org/10.1007/bf01059183