Cellular Adjuvant Properties, Direct Cytotoxicity of Re-differentiated Vα24 Invariant NKT-like Cells from Human Induced Pluripotent Stem Cells

Autor: Shuichi Kitayama, Rong Zhang, Tian-Yi Liu, Norihiro Ueda, Shoichi Iriguchi, Yutaka Yasui, Yohei Kawai, Minako Tatsumi, Norihito Hirai, Yasutaka Mizoro, Tatsuaki Iwama, Akira Watanabe, Mahito Nakanishi, Kiyotaka Kuzushima, Yasushi Uemura, Shin Kaneko

Publikováno v: Stem Cell Reports, Vol 6, Iss 2, Pp 213-227 (2016)

Vα24 invariant natural killer T (iNKT) cells are a subset of T lymphocytes implicated in the regulation of broad immune responses. They recognize lipid antigens presented by CD1d on antigen-presenting cells and induce both innate and adaptive immune

Externí odkaz: https://doaj.org/article/396ffa23b1b54d009b74864dae16da4a

A light-induced small G-protein gem limits the circadian clock phase-shift magnitude by inhibiting voltage-dependent calcium channels

Autor: Masahiro Matsuo, Kazuyuki Seo, Akiyuki Taruno, Yasutaka Mizoro, Yoshiaki Yamaguchi, Masao Doi, Rhyuta Nakao, Hiroshi Kori, Takaya Abe, Harunori Ohmori, Keiko Tominaga, Hitoshi Okamura

Publikováno v: Cell Reports. 39:110844

Calcium signaling is pivotal to the circadian clockwork in the suprachiasmatic nucleus (SCN), particularly in rhythm entrainment to environmental light-dark cycles. Here, we show that a small G-protein Gem, an endogenous inhibitor of high-voltage-act

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8491e61fd341183e0b6e8a01b2622da0
https://doi.org/10.1016/j.celrep.2022.110844

Circadian clock mechanism driving mammalian photoperiodism

Autor: Helen C. Christian, Andrew S. I. Loudon, Matthew Hindle, Yasutaka Mizoro, Dave Burt, Ben Saer, Shona H. Wood, Judith McNeilly, Alan S. McNeilly, Yung Sung Cheng, Katarzyna Miedzinska, Simone Meddle, Nicola Begley

Publikováno v: Wood, S, Hindle, M, Mizoro, Y, Cheng, Y, Saer, B, Miedzinska-Bielecka, K, Christian, H, Begley, N, J, M, McNeilly, A, Meddle, S, Burt, D & Loudon, A 2020, ' Circadian clock mechanism driving mammalian photoperiodism. ', Nature Communications, vol. 11, 4291 (2020), pp. 1-15 . https://doi.org/10.1038/s41467-020-18061-z
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications
Wood, S, Hindle, M M, Mizoro, Y, Cheng, Y, Saer, B, Miedzinska, K, Christian, H C, Begley, N, McNeilly, J, McNeilly, A S, Meddle, S L, Burt, D W & Loudon, A 2020, ' Circadian clock mechanism driving mammalian photoperiodism ', Nature Communications, vol. 11, 4291 . https://doi.org/10.1038/s41467-020-18061-z

The annual photoperiod cycle provides the critical environmental cue synchronizing rhythms of life in seasonal habitats. In 1936, Bünning proposed a circadian-based coincidence timer for photoperiodic synchronization in plants. Formal studies suppor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbe68ec4d59282f4ea3b26b1fb3be070
https://hdl.handle.net/20.500.11820/5e075f9c-9115-4113-8aa7-1d78e2ed165d

Transcriptional Analysis of Intravenous Immunoglobulin Resistance in Kawasaki Disease Using an Induced Pluripotent Stem Cell Disease Model

Autor: Tomonaga Ameku, Kenji Osafune, Kazuyuki Ikeda, Yui Nomiya, Yuki Kuchitsu, Kenji Hamaoka, Chinatsu Suzuki, Akiko Hamaoka-Okamoto, Masakatsu Sone, Satoshi Matsui, Keisuke Okita, Tomoyo Yahata, Shin-Ichi Mae, Akira Watanabe, Yasutaka Mizoro

Publikováno v: Circulation Journal. 81:110-118

Background Approximately 10-20% of Kawasaki disease (KD) patients are resistant to intravenous immunoglobulin (IVIG) treatment. Further, these patients are at a particularly high risk of having coronary artery abnormalities. The mechanisms of IVIG re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d79c3405ce0b6e8a0e29802de5e2ec4f
https://doi.org/10.1253/circj.cj-16-0541

Cellular Adjuvant Properties, Direct Cytotoxicity of Re-differentiated Vα24 Invariant NKT-like Cells from Human Induced Pluripotent Stem Cells

Autor: Tatsuaki Iwama, Shin Kaneko, Shuichi Kitayama, Yohei Kawai, Kiyotaka Kuzushima, Yutaka Yasui, Akira Watanabe, Norihito Hirai, Minako Tatsumi, Yasutaka Mizoro, Norihiro Ueda, Rong Zhang, Mahito Nakanishi, Shoichi Iriguchi, Yasushi Uemura, Tianyi Liu

Publikováno v: Stem Cell Reports
Stem Cell Reports, Vol 6, Iss 2, Pp 213-227 (2016)

Summary Vα24 invariant natural killer T (iNKT) cells are a subset of T lymphocytes implicated in the regulation of broad immune responses. They recognize lipid antigens presented by CD1d on antigen-presenting cells and induce both innate and adaptiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b973954f7383597fe55b72e89c5997b0
https://doi.org/10.1016/j.stemcr.2016.01.005