Zobrazeno 1 - 10
of 100
pro vyhledávání: '"Yasushi Yabuki"'
Publikováno v:
Journal of Pharmacological Sciences, Vol 140, Iss 3, Pp 263-272 (2019)
Atypical antipsychotics improve positive and negative symptoms but are not effective for treating cognitive impairments in patients with schizophrenia. We previously reported that cognitive impairments in neonatal ventral hippocampus (NVH)-lesioned r
Externí odkaz:
https://doaj.org/article/987e776ecf674ce7b31f1e779ef02531
Autor:
Eri Nakazaki, Yasushi Yabuki, Hisanao Izumi, Yasuharu Shinoda, Fumiko Watanabe, Yukihiro Hishida, Ayako Kamimura, Kohji Fukunaga
Publikováno v:
Journal of Pharmacological Sciences, Vol 139, Iss 4, Pp 319-324 (2019)
Phospholipids are structural components of cellular membranes that play important roles as precursors for various signaling pathways in modulating neuronal membrane function and maintenance of the intracellular environment. Phosphatidylcholine (PtdCh
Externí odkaz:
https://doaj.org/article/514d2e73c8f9430a8cee2f84efde3c39
Publikováno v:
Journal of Pharmacological Sciences, Vol 139, Iss 2, Pp 51-58 (2019)
Low-threshold Ca2+ spikes are mediated by T-type Ca2+ channels, which have electrophysiological properties of fast inactivation and slow deactivation kinetics. A low membrane potential of approximately −60 mV is sufficient to trigger channel openin
Externí odkaz:
https://doaj.org/article/5337bd46dd0243df955ee8be7ac0aa17
Autor:
Osamu Nakagawasai, Jia-Rong Lin, Takayo Odaira, Kohei Takahashi, Wataru Nemoto, Shigeki Moriguchi, Yasushi Yabuki, Yu Kobayakawa, Kohji Fukunaga, Masahisa Nakada, Koichi Tan-No
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
A previous study reported that scabronine G methyl ester (SG-ME) potentially enhances the in vitro secretion of neurotrophic factors such as nerve growth factor via the protein kinase C (PKC)-ζ pathway. However, it remains unknown whether SG-ME can
Externí odkaz:
https://doaj.org/article/33de06a0574045b4a438787e310149a7
Publikováno v:
Journal of Pharmacological Sciences, Vol 137, Iss 4, Pp 333-341 (2018)
T-type calcium channels are involved in the pathophysiology of epilepsy, pain, and sleep. Recently, we developed a novel spiroimidazopyridine compound, SAK3 (ethyl 8′-methyl-2′,4-dioxo-2-(piperidin-1-yl)-2′H-spiro[cyclopentane-1,3′-imidazo[1,
Externí odkaz:
https://doaj.org/article/463d078dd5c24821b369efc450223ce4
Autor:
Shuo Wang, Yasushi Yabuki, Kazuya Matsuo, Jing Xu, Hisanao Izumi, Kenji Sakimura, Takashi Saito, Takaomi C Saido, Kohji Fukunaga
Publikováno v:
PLoS ONE, Vol 14, Iss 1, p e0211590 (2019)
[This corrects the article DOI: 10.1371/journal.pone.0206986.].
Externí odkaz:
https://doaj.org/article/1ff0cde678ff4ab996c2065fce923431
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 1, p 400 (2021)
In synucleinopathies, while motor symptoms are thought to be attributed to the accumulation of misfolded α-synuclein (αSyn) in nigral dopaminergic neurons, it remains to be elucidated how cognitive decline arises. Here, we investigated the effects
Externí odkaz:
https://doaj.org/article/5416ed8d9ee94df986c654f97a0eca1e
Autor:
Yasushi Yabuki, Jiaqi Liu, Ichiro Kawahata, Hisanao Izumi, Yasuharu Shinoda, Kohei Koga, Shinya Ueno, Norifumi Shioda, Kohji Fukunaga
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 15, p 5525 (2020)
Recently, we developed the fatty acid-binding protein 3 (FABP3) ligand MF1 (4-(2-(1-(2-chlorophenyl)-5-phenyl-1H-pyrazol-3-yl)phenoxy) butanoic acid) as a therapeutic candidate for α-synucleinopathies. MF1 shows affinity towards γ-aminobutyric acid
Externí odkaz:
https://doaj.org/article/be03291cd04c44c2b088f22b02aa8eb8
Autor:
Yasushi Yabuki, Kazuya Matsuo, Ichiro Kawahata, Naoya Fukui, Tomohiro Mizobata, Yasushi Kawata, Yuji Owada, Norifumi Shioda, Kohji Fukunaga
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 6, p 2230 (2020)
Oligomerization and/or aggregation of α-synuclein (α-Syn) triggers α-synucleinopathies such as Parkinson’s disease and dementia with Lewy bodies. It is known that α-Syn can spread in the brain like prions; however, the mechanism remains unclear
Externí odkaz:
https://doaj.org/article/eab4c741ccad40fdb03902c8abf33821
Autor:
Shuo Wang, Yasushi Yabuki, Kazuya Matsuo, Jing Xu, Hisanao Izumi, Kenji Sakimura, Takashi Saito, Takaomi C Saido, Kohji Fukunaga
Publikováno v:
PLoS ONE, Vol 13, Iss 12, p e0206986 (2018)
T-type calcium channels in the brain mediate the pathophysiology of epilepsy, pain, and sleep. Recently, we developed a novel therapeutic candidate, SAK3 (ethyl 8'-methyl-2',4-dioxo-2-(piperidin-1-yl)-2'H-spiro[cyclopentane-1,3'-imidazo[1,2-a] pyridi
Externí odkaz:
https://doaj.org/article/5c3dbc0c34db4e3283434983af14c190