Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Yasushi Uemura"'
Autor:
Liangliang Wu, Yiming Gao, Shengzhi Xie, Wan Ye, Yasushi Uemura, Rong Zhang, Yanju Yu, Jinfeng Li, Man Chen, Qiyan Wu, Pengfei Cui, Hongyu Liu, Shuai Mu, Yilan Li, Lingxiong Wang, Chunxi Liu, Jiahui Li, Lijun Zhang, Shunchang Jiao, Guoqing Zhang, Tianyi Liu
Publikováno v:
Translational Oncology, Vol 37, Iss , Pp 101775- (2023)
Purpose: This study aimed to screen biomarkers to predict the efficacy of programmed cell death 1 (PD-1) blockade immunotherapy combined with chemotherapy as neoadjuvant therapy for esophageal squamous cell carcinoma (ESCC). Methods: In the first sta
Externí odkaz:
https://doaj.org/article/baa18bcaa952461180a0e4e00f36ab02
Autor:
Hiroaki Mashima, Rong Zhang, Tsuyoshi Kobayashi, Hirotake Tsukamoto, Tianyi Liu, Tatsuaki Iwama, Yuichiro Hagiya, Masateru Yamamoto, Satoshi Fukushima, Seiji Okada, Alimjan Idiris, Shin Kaneko, Tetsuya Nakatsura, Hideki Ohdan, Yasushi Uemura
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 21, Iss , Pp 171-179 (2021)
The tumorigenicity and toxicity of induced pluripotent stem cells (iPSCs) and their derivatives are major safety concerns in their clinical application. Recently, we developed granulocyte-macrophage colony-stimulating factor (GM-CSF)-producing prolif
Externí odkaz:
https://doaj.org/article/56ea2a8f25684d90bfd5080dffd495c7
Autor:
Shaoping Shen, Ling Chen, Jialin Liu, Lin Yang, Mengna Zhang, Lingxiong Wang, Rong Zhang, Yasushi Uemura, Qiyan Wu, Xinguang Yu, Tianyi Liu
Publikováno v:
Cancer Biology & Medicine, Vol 17, Iss 3, Pp 555-568 (2020)
In the interaction between a tumor and the immune system, immune checkpoints play an important role, and in tumor immune escape, co-inhibitory immune checkpoints are important. Immune checkpoint inhibitors (ICIs) can enhance the immune system’s kil
Externí odkaz:
https://doaj.org/article/407aa98ee9684d968bde9686533069b8
Autor:
Hiroaki Mashima, Rong Zhang, Tsuyoshi Kobayashi, Yuichiro Hagiya, Hirotake Tsukamoto, Tianyi Liu, Tatsuaki Iwama, Masateru Yamamoto, Chiahsuan Lin, Ryusuke Nakatsuka, Yuta Mishima, Noriko Watanabe, Takashi Yamada, Satoru Senju, Shin Kaneko, Alimjan Idiris, Tetsuya Nakatsura, Hideki Ohdan, Yasushi Uemura
Publikováno v:
OncoImmunology, Vol 9, Iss 1 (2020)
Immunotherapy using dendritic cells (DCs) is a promising treatment modality for cancer. However, the limited number of functional DCs from peripheral blood has been linked to the unsatisfactory clinical efficacies of current DC-based cancer immunothe
Externí odkaz:
https://doaj.org/article/97057ff2950a43e8858f76e78e9bec65
Autor:
Nobuhiro Tsuchiya, Rong Zhang, Tatsuaki Iwama, Norihiro Ueda, Tianyi Liu, Minako Tatsumi, Yutaka Sasaki, Ranmaru Shimoda, Yuki Osako, Yu Sawada, Yosuke Kubo, Azusa Miyashita, Satoshi Fukushima, Zhao Cheng, Ryo Nakaki, Keiyo Takubo, Seiji Okada, Shin Kaneko, Hironobu Ihn, Tsuneyasu Kaisho, Yasuharu Nishimura, Satoru Senju, Itaru Endo, Tetsuya Nakatsura, Yasushi Uemura
Publikováno v:
Cell Reports, Vol 29, Iss 1, Pp 162-175.e9 (2019)
Summary: Type I interferons (IFNs) play important roles in antitumor immunity. We generated IFN-α-producing cells by genetically engineered induced pluripotent stem cell (iPSC)-derived proliferating myeloid cells (iPSC-pMCs). Local administration of
Externí odkaz:
https://doaj.org/article/10e8ff19e2ed49ff9f9f1af0099b33bd
Autor:
Norihiro Fujinami, Toshiaki Yoshikawa, Yu Sawada, Manami Shimomura, Tatsuaki Iwama, Shiori Sugai, Shigehisa Kitano, Yasushi Uemura, Tetsuya Nakatsura
Publikováno v:
Biochemistry and Biophysics Reports, Vol 5, Iss C, Pp 482-491 (2016)
Purpose: The clinical efficacy of cancer peptide vaccine therapy is insufficient. To enhance the anti-tumor effect of peptide vaccine therapy, we combined this therapy with an anti-CD4 mAb (GK1.5), which is known to deplete CD4+ cells, including regu
Externí odkaz:
https://doaj.org/article/abe1098a9e3e4ddebc235da700710c18
Autor:
Shuichi Kitayama, Rong Zhang, Tian-Yi Liu, Norihiro Ueda, Shoichi Iriguchi, Yutaka Yasui, Yohei Kawai, Minako Tatsumi, Norihito Hirai, Yasutaka Mizoro, Tatsuaki Iwama, Akira Watanabe, Mahito Nakanishi, Kiyotaka Kuzushima, Yasushi Uemura, Shin Kaneko
Publikováno v:
Stem Cell Reports, Vol 6, Iss 2, Pp 213-227 (2016)
Vα24 invariant natural killer T (iNKT) cells are a subset of T lymphocytes implicated in the regulation of broad immune responses. They recognize lipid antigens presented by CD1d on antigen-presenting cells and induce both innate and adaptive immune
Externí odkaz:
https://doaj.org/article/396ffa23b1b54d009b74864dae16da4a
Autor:
Ryusuke Nakatsuka, Yoshikazu Matsuoka, Yasushi Uemura, Keisuke Sumide, Ryuji Iwaki, Masaya Takahashi, Tatsuya Fujioka, Yutaka Sasaki, Yoshiaki Sonoda M.D., Ph.D.
Publikováno v:
Cell Transplantation, Vol 24 (2015)
It is well documented that specialized mesenchymal stem/stromal cells (MSCs) constitute the hematopoietic stem cell (HSC) niche in the bone marrow (BM), and these MSCs support/maintain the HSCs in an undifferentiated state. A number of studies have d
Externí odkaz:
https://doaj.org/article/f426f2a870d144b5bb61d1bc6dda1cea
Autor:
Tianyi Liu, Hitoshi Kohsaka, Motoharu Suzuki, Rie Takagi, Kumiko Hashimoto, Yasushi Uemura, Hideki Ohyama, Sho Matsushita
Publikováno v:
Allergology International, Vol 54, Iss 1, Pp 117-122 (2005)
Background: Based on the fact that site-specific amino acid replacement on peptide antigens stimulated T cell clones to produce increased amount of IFN-γ, we investigated this structure-function relationship, using various peptide analogues. Methods
Externí odkaz:
https://doaj.org/article/f8be1fc561a34de18e7ba9255db2aa35
Publikováno v:
Allergology International, Vol 54, Iss 4, Pp 507-513 (2005)
It is well-known that many isoforms of toll-like receptors (TLRs) function as Th1 adjuvant receptors. Thus, the ligands induce Th1 differentiation in an antigen non-specific manner. During the past few years, not only Th1, but also Th2 adjuvants have
Externí odkaz:
https://doaj.org/article/ccfe1d595cba4a17884efac7a86129eb