Zobrazeno 1 - 10
of 123
pro vyhledávání: '"Yasushi Totoki"'
Autor:
Shoko Ikuta, Yutaka Saito, So Takata, Yoichiro Nakatani, Izumi Nagatomo, Satoshi Shiba, Yoshito Takeda, Yasushi Totoki, Sayaka Mizutani, Hironori Sunakawa, Hiroaki Ikematsu, Hiroyuki Takamaru, Atsushi Kumanogoh, Shinichi Yachida
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-10 (2024)
Abstract A comprehensive endoscopic small and large intestinal untargeted step biopsy procedure was conducted to compare gene expression between the normal intestinal mucosa of healthy individuals and that of patients with colorectal tumors. From 78
Externí odkaz:
https://doaj.org/article/58a6c10f95a242f2b48eed9ce8678773
Autor:
Akihiko Fukagawa, Natsuko Hama, Yasushi Totoki, Hiromi Nakamura, Yasuhito Arai, Mihoko Saito-Adachi, Akiko Maeshima, Yoshiyuki Matsui, Shinichi Yachida, Tetsuo Ushiku, Tatsuhiro Shibata
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Renal cell carcinoma (RCC) comprises several histological types characterised by different genomic and epigenomic aberrations; however, the molecular pathogenesis of each type still requires further exploration. We perform whole-genome seque
Externí odkaz:
https://doaj.org/article/f064165921734a9bac29a6d35ccc5349
Autor:
Mihoko Saito-Adachi, Natsuko Hama, Yasushi Totoki, Hiromi Nakamura, Yasuhito Arai, Fumie Hosoda, Hirofumi Rokutan, Shinichi Yachida, Mamoru Kato, Akihiko Fukagawa, Tatsuhiro Shibata
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Structural variants (SVs) are responsible for driver events in gastric cancer (GC); however, their patterns and processes remain poorly understood. Here, we examine 170 GC whole genomes to unravel the oncogenic structural aberration landscap
Externí odkaz:
https://doaj.org/article/a521e2d770ec44e0b630ad375453251d
Autor:
Shotaro Sakimura, Satoshi Nagayama, Mitsuko Fukunaga, Qingjiang Hu, Akihiro Kitagawa, Yuta Kobayashi, Takanori Hasegawa, Miwa Noda, Yuta Kouyama, Dai Shimizu, Tomoko Saito, Atsushi Niida, Yusuke Tsuruda, Hajime Otsu, Yoshihiro Matsumoto, Hiroki Uchida, Takaaki Masuda, Keishi Sugimachi, Shin Sasaki, Kazutaka Yamada, Kazuki Takahashi, Hideki Innan, Yutaka Suzuki, Hiromi Nakamura, Yasushi Totoki, Shinichi Mizuno, Masanobu Ohshima, Tatsuhiro Shibata, Koshi Mimori
Publikováno v:
PLoS Genetics, Vol 17, Iss 1, p e1009113 (2021)
A Darwinian evolutionary shift occurs early in the neutral evolution of advanced colorectal carcinoma (CRC), and copy number aberrations (CNA) are essential in the transition from adenoma to carcinoma. In light of this primary evolution, we investiga
Externí odkaz:
https://doaj.org/article/368965ee3f5c406883ce91f3142e4dd0
Autor:
Koichi Ogura, Fumie Hosoda, Yasuhito Arai, Hiromi Nakamura, Natsuko Hama, Yasushi Totoki, Akihiko Yoshida, Momoko Nagai, Mamoru Kato, Erika Arakawa, Wakako Mukai, Hirofumi Rokutan, Akira Kawai, Sakae Tanaka, Tatsuhiro Shibata
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Myxofibrosarcoma occurs in adults and is associated with high local relapse. Here, based on exome/transcriptome sequencing and DNA methylation analysis, the authors identify driver genes and methylation clusters associated with unique combinations of
Externí odkaz:
https://doaj.org/article/f38d14ba97c849c9b84a8c13e9c3779d
Autor:
Mamoru Kato, Hiromi Nakamura, Momoko Nagai, Takashi Kubo, Asmaa Elzawahry, Yasushi Totoki, Yuko Tanabe, Eisaku Furukawa, Joe Miyamoto, Hiromi Sakamoto, Shingo Matsumoto, Kuniko Sunami, Yasuhito Arai, Yutaka Suzuki, Teruhiko Yoshida, Katsuya Tsuchihara, Kenji Tamura, Noboru Yamamoto, Hitoshi Ichikawa, Takashi Kohno, Tatsuhiro Shibata
Publikováno v:
Genome Medicine, Vol 10, Iss 1, Pp 1-11 (2018)
Abstract Advanced cancer genomics technologies are now being employed in clinical sequencing, where next-generation sequencers are used to simultaneously identify multiple types of DNA alterations for prescription of molecularly targeted drugs. Howev
Externí odkaz:
https://doaj.org/article/fce8bdc9b51943338a4f8ede1452eb79
Autor:
Natsuko Hama, Yasushi Totoki, Fumihito Miura, Kenji Tatsuno, Mihoko Saito-Adachi, Hiromi Nakamura, Yasuhito Arai, Fumie Hosoda, Tomoko Urushidate, Shoko Ohashi, Wakako Mukai, Nobuyoshi Hiraoka, Hiroyuki Aburatani, Takashi Ito, Tatsuhiro Shibata
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Genomic aberrations contribute to the development of cancer; however, their interdependence remains poorly understood. Here the authors analyze liver cancer samples to find correlation between epigenetic features and genetic aberrations including som
Externí odkaz:
https://doaj.org/article/103a2a78264e49439ad7afad15a26081
Autor:
Keisuke Katsushima, Atsushi Natsume, Fumiharu Ohka, Keiko Shinjo, Akira Hatanaka, Norihisa Ichimura, Shinya Sato, Satoru Takahashi, Hiroshi Kimura, Yasushi Totoki, Tatsuhiro Shibata, Mitsuru Naito, Hyun Jin Kim, Kanjiro Miyata, Kazunori Kataoka, Yutaka Kondo
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Self-renewal of cancer stem cells can contribute to glioma progression. Here, the authors show that Notch1 activation in glioma stem cells induces expression of the lncRNATUG1, which promotes self-renewal through the repression of differentiation gen
Externí odkaz:
https://doaj.org/article/36464f0713394d1ea6623709d1ee83d9
Autor:
Masahito Kawazu, Shinya Kojima, Toshihide Ueno, Yasushi Totoki, Hiromi Nakamura, Akiko Kunita, Wei Qu, Jun Yoshimura, Manabu Soda, Takahiko Yasuda, Natsuko Hama, Mihoko Saito-Adachi, Kazuhito Sato, Shinji Kohsaka, Eirin Sai, Masako Ikemura, Shigeru Yamamoto, Tomoko Ogawa, Masashi Fukayama, Keiichiro Tada, Yasuyuki Seto, Shinichi Morishita, Shoichi Hazama, Tatsuhiro Shibata, Yoshihiro Yamashita, Hiroyuki Mano
Publikováno v:
PLoS Genetics, Vol 13, Iss 6, p e1006853 (2017)
Triple-negative breast cancer (TNBC) cells do not express estrogen receptors, progesterone receptors, or human epidermal growth factor receptor 2. Currently, apart from poly ADP-ribose polymerase inhibitors, there are few effective therapeutic option
Externí odkaz:
https://doaj.org/article/6a162a70df7847e08883bac287297886
Autor:
Shin Kobayashi, Yasushi Totoki, Miki Soma, Kazuya Matsumoto, Yoshitaka Fujihara, Atsushi Toyoda, Yoshiyuki Sakaki, Masaru Okabe, Fumitoshi Ishino
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e71222 (2013)
Mammalian development is strongly influenced by the epigenetic phenomenon called genomic imprinting, in which either the paternal or the maternal allele of imprinted genes is expressed. Paternally expressed Xist, an imprinted gene, has been considere
Externí odkaz:
https://doaj.org/article/9bafbfc8e4574b77902312b5247ace18