Zobrazeno 1 - 10
of 208
pro vyhledávání: '"Yasushi Totoki"'
Autor:
Shoko Ikuta, Yutaka Saito, So Takata, Yoichiro Nakatani, Izumi Nagatomo, Satoshi Shiba, Yoshito Takeda, Yasushi Totoki, Sayaka Mizutani, Hironori Sunakawa, Hiroaki Ikematsu, Hiroyuki Takamaru, Atsushi Kumanogoh, Shinichi Yachida
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-10 (2024)
Abstract A comprehensive endoscopic small and large intestinal untargeted step biopsy procedure was conducted to compare gene expression between the normal intestinal mucosa of healthy individuals and that of patients with colorectal tumors. From 78
Externí odkaz:
https://doaj.org/article/58a6c10f95a242f2b48eed9ce8678773
Autor:
Akihiko Fukagawa, Natsuko Hama, Yasushi Totoki, Hiromi Nakamura, Yasuhito Arai, Mihoko Saito-Adachi, Akiko Maeshima, Yoshiyuki Matsui, Shinichi Yachida, Tetsuo Ushiku, Tatsuhiro Shibata
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Renal cell carcinoma (RCC) comprises several histological types characterised by different genomic and epigenomic aberrations; however, the molecular pathogenesis of each type still requires further exploration. We perform whole-genome seque
Externí odkaz:
https://doaj.org/article/f064165921734a9bac29a6d35ccc5349
Autor:
Mihoko Saito-Adachi, Natsuko Hama, Yasushi Totoki, Hiromi Nakamura, Yasuhito Arai, Fumie Hosoda, Hirofumi Rokutan, Shinichi Yachida, Mamoru Kato, Akihiko Fukagawa, Tatsuhiro Shibata
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Structural variants (SVs) are responsible for driver events in gastric cancer (GC); however, their patterns and processes remain poorly understood. Here, we examine 170 GC whole genomes to unravel the oncogenic structural aberration landscap
Externí odkaz:
https://doaj.org/article/a521e2d770ec44e0b630ad375453251d
Autor:
Yasushi Totoki, Mihoko Saito-Adachi, Yuichi Shiraishi, Daisuke Komura, Hiromi Nakamura, Akihiro Suzuki, Kenji Tatsuno, Hirofumi Rokutan, Natsuko Hama, Shogo Yamamoto, Hanako Ono, Yasuhito Arai, Fumie Hosoda, Hiroto Katoh, Kenichi Chiba, Naoko Iida, Genta Nagae, Hiroki Ueda, Chen Shihang, Shigeki Sekine, Hiroyuki Abe, Sachiyo Nomura, Tetsuya Matsuura, Eiji Sakai, Takashi Ohshima, Yasushi Rino, Khay Guan Yeoh, Jimmy So, Kaushal Sanghvi, Richie Soong, Akihiko Fukagawa, Shinichi Yachida, Mamoru Kato, Yasuyuki Seto, Tetsuo Ushiku, Atsushi Nakajima, Hitoshi Katai, Patrick Tan, Shumpei Ishikawa, Hiroyuki Aburatani, Tatsuhiro Shibata
Publikováno v:
Nature Genetics. 55:581-594
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7528696c43854d78c200f5fbf72cbc3
https://doi.org/10.1038/s41588-023-01333-x
https://doi.org/10.1038/s41588-023-01333-x
Autor:
Shotaro Sakimura, Satoshi Nagayama, Mitsuko Fukunaga, Qingjiang Hu, Akihiro Kitagawa, Yuta Kobayashi, Takanori Hasegawa, Miwa Noda, Yuta Kouyama, Dai Shimizu, Tomoko Saito, Atsushi Niida, Yusuke Tsuruda, Hajime Otsu, Yoshihiro Matsumoto, Hiroki Uchida, Takaaki Masuda, Keishi Sugimachi, Shin Sasaki, Kazutaka Yamada, Kazuki Takahashi, Hideki Innan, Yutaka Suzuki, Hiromi Nakamura, Yasushi Totoki, Shinichi Mizuno, Masanobu Ohshima, Tatsuhiro Shibata, Koshi Mimori
Publikováno v:
PLoS Genetics, Vol 17, Iss 1, p e1009113 (2021)
A Darwinian evolutionary shift occurs early in the neutral evolution of advanced colorectal carcinoma (CRC), and copy number aberrations (CNA) are essential in the transition from adenoma to carcinoma. In light of this primary evolution, we investiga
Externí odkaz:
https://doaj.org/article/368965ee3f5c406883ce91f3142e4dd0
Autor:
Koichi Ogura, Fumie Hosoda, Yasuhito Arai, Hiromi Nakamura, Natsuko Hama, Yasushi Totoki, Akihiko Yoshida, Momoko Nagai, Mamoru Kato, Erika Arakawa, Wakako Mukai, Hirofumi Rokutan, Akira Kawai, Sakae Tanaka, Tatsuhiro Shibata
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Myxofibrosarcoma occurs in adults and is associated with high local relapse. Here, based on exome/transcriptome sequencing and DNA methylation analysis, the authors identify driver genes and methylation clusters associated with unique combinations of
Externí odkaz:
https://doaj.org/article/f38d14ba97c849c9b84a8c13e9c3779d
Autor:
Mamoru Kato, Hiromi Nakamura, Momoko Nagai, Takashi Kubo, Asmaa Elzawahry, Yasushi Totoki, Yuko Tanabe, Eisaku Furukawa, Joe Miyamoto, Hiromi Sakamoto, Shingo Matsumoto, Kuniko Sunami, Yasuhito Arai, Yutaka Suzuki, Teruhiko Yoshida, Katsuya Tsuchihara, Kenji Tamura, Noboru Yamamoto, Hitoshi Ichikawa, Takashi Kohno, Tatsuhiro Shibata
Publikováno v:
Genome Medicine, Vol 10, Iss 1, Pp 1-11 (2018)
Abstract Advanced cancer genomics technologies are now being employed in clinical sequencing, where next-generation sequencers are used to simultaneously identify multiple types of DNA alterations for prescription of molecularly targeted drugs. Howev
Externí odkaz:
https://doaj.org/article/fce8bdc9b51943338a4f8ede1452eb79
Autor:
Natsuko Hama, Yasushi Totoki, Fumihito Miura, Kenji Tatsuno, Mihoko Saito-Adachi, Hiromi Nakamura, Yasuhito Arai, Fumie Hosoda, Tomoko Urushidate, Shoko Ohashi, Wakako Mukai, Nobuyoshi Hiraoka, Hiroyuki Aburatani, Takashi Ito, Tatsuhiro Shibata
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Genomic aberrations contribute to the development of cancer; however, their interdependence remains poorly understood. Here the authors analyze liver cancer samples to find correlation between epigenetic features and genetic aberrations including som
Externí odkaz:
https://doaj.org/article/103a2a78264e49439ad7afad15a26081
Autor:
Keisuke Katsushima, Atsushi Natsume, Fumiharu Ohka, Keiko Shinjo, Akira Hatanaka, Norihisa Ichimura, Shinya Sato, Satoru Takahashi, Hiroshi Kimura, Yasushi Totoki, Tatsuhiro Shibata, Mitsuru Naito, Hyun Jin Kim, Kanjiro Miyata, Kazunori Kataoka, Yutaka Kondo
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Self-renewal of cancer stem cells can contribute to glioma progression. Here, the authors show that Notch1 activation in glioma stem cells induces expression of the lncRNATUG1, which promotes self-renewal through the repression of differentiation gen
Externí odkaz:
https://doaj.org/article/36464f0713394d1ea6623709d1ee83d9
Autor:
Tatsuhiro Shibata, Ralph H. Hruban, Laura D. Wood, Lodewijk A.A. Brosens, Tohru Kiyono, Toshiro Sato, Toru Furukawa, Koji Arihiro, Chigusa Morizane, Hiroki Yamaue, Masakazu Yamamoto, Keiichi Okano, Tomoyuki Okumura, Wenzel M. Hackeng, Minoru Oshima, Ayaka Shimomura, So Takata, Hidenori Tanaka, Mitsuro Kanda, Shuichi Mitsunaga, Taiki Hashimoto, Hirofumi Rokutan, Yasuhito Arai, Eisaku Furukawa, Mamoru Kato, Satoshi Shiba, Seiko Hirono, Ryota Higuchi, Natsuko Hama, Erina Takai, Masami Suzuki, Mihoko Saito-Adachi, Hiromi Nakamura, Kenta Kawasaki, Masafumi Horie, Yoichiro Nakatani, Michaël Noë, Yasushi Totoki, Shinichi Yachida
The neuroendocrine carcinoma of the gastrointestinal system (GIS-NEC) is a rare but highly malignant neoplasm. We analyzed 115 cases using whole-genome/exome sequencing, transcriptome sequencing, DNA methylation assays, and/or ATAC-seq and found GIS-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b286a0d38eb47508245ed9b7025188c9
https://doi.org/10.1158/2159-8290.c.6549530.v1
https://doi.org/10.1158/2159-8290.c.6549530.v1
