Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Yasushi Takagishi"'
Publikováno v:
Biological and Pharmaceutical Bulletin. 18:321-325
The action of benzyl alcohol (BA) as a major solvent of a liquid droplet dispersion ointment (LDDS), a preparation enabling excellent percutaneous absorption of drugs, was evaluated and compared with Azone and dimethyl sulfoxide (DMSO), which are kno
Publikováno v:
Chemical and Pharmaceutical Bulletin. 43:1012-1016
The hydrophobic interaction between long-chain alkyl groups of hydrophobically-modified hydroxypropyl methylcellulose (HM-HPMC) and indomethacin (IM) was studied using a fluorescence probe method in which pyrene molecules are allowed to associate wit
Publikováno v:
Pharmaceutical Research. 12:1333-1337
Purpose. To establish the evaluating method for drug dissolution profiles in the gastrointestinal (GI) tract based on in vitro data for the enteric-coated multiple unit. Methods. Dissolution profile in the GI tract was calculated by the convolution p
Publikováno v:
Biomedical Chromatography. 8:9-13
This paper describes a method suitable for purifying immunotoxin containing type 1 ribosome-inactivating protein, gelonin. The separation of free (unreacted) 80G, a monoclonal antibody against alpha-fetoprotein (AFP), from semipurified 80G-gelonin co
Publikováno v:
Chemical and Pharmaceutical Bulletin. 42:2320-2326
Hydrophobically-modified hydroxypropyl methylcellulose (HM-HPMC), possessing long-chain alkyl groups, is a new thickening agent for gel preparations. The solubility of indomethacin (IM) in supersaturated solutions increased with HM-HPMC concentration
Publikováno v:
YAKUGAKU ZASSHI. 114:1005-1014
The sustained release mechanism of gentamicin (GM) from lactic acid/glycolic acid copolymer (PLGA) microspheres was investigated. The terminal free carboxyl group of polymer was proved to be necessary for GM to be highly incorporated into microsphere
Publikováno v:
Drug Delivery System. 9:13-18
Publikováno v:
Pharmaceutical Research. 11:508-512
The partition of mepitiostane, testosterone, and some structurally related compounds between lymph and blood in rat jejunum (lymph–blood partition ratio; LBPR) was determined, and the quantitative relationship between LBPR and lipophilicity was exa
Publikováno v:
Journal of Drug Targeting. 2:323-331
This study was carried out to evaluate our monoclonal antibody (MoAb) to alpha-fetoprotein (AFP), 80G, as a carrier for targeting AFP-producing hepatoma. Pharmacokinetic analysis showed that the MoAb 80G was actively incorporated into AFP-producing H
Publikováno v:
Tumor Biology. 15:175-183
Two thioether-linked conjugates composed of monoclonal antibody (MoAb) to alpha-fetoprotein (AFP), 80G or its F(ab')2 fragment, and a type 1 ribosome-inactivating protein (RIP), gelonin, were prepared as potent immunotoxins [80G-CS-GL(IT) and F(ab')2