Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Yasushi Sunami"'
Autor:
Yasushi Sunami, Kuniharu Nakai, Susumu Tazuma, Minoru Sakomoto, Kazuhiko Tsuboi, Yoshihiro Nonaka, Kazuaki Chayama, Hidenori Ochi, Yasumasa Asamoto, Daisuke Komichi, Atsushi Yamaguchi, Tomoji Nishioka, Keishi Kanno, Hideyuki Hyogo, Toshiya Kobuke, Yoshihiro Numata
Publikováno v:
Journal of Gastroenterology and Hepatology. 18:157-161
Background: Absorption of water, as well as emptying of bile, are important functions of the gallbladder. We studied the changes of gallbladder function with age in gallstone patients and their influence on the outcome of extracorporeal shockwave lit
Autor:
Hidenori Ochi, Kuniharu Nakai, Keishi Kanno, Tomoji Nishioka, Kazuhiko Tsuboi, Yasushi Sunami, Susumu Tazuma, Yoshihiro Numata, Hideyuki Hyogo, Goro Kajiyama, Atushi Yamaguchi, Shigeyuki Yasumiba, Minoru Sakomoto, Yasumasa Asamoto
Publikováno v:
Digestive Diseases and Sciences. 46:2089-2097
Biliary components are transported by hepatic adenosine triphosphate-binding cassette (ABC) transporters that are located in canalicular membranes. Physiological transporter function is related to membrane fluidity, which is modulated by the phosphol
Autor:
Kazuhiko Horikawa, Yasushi Sunami, Kazuaki Chayama, Kuniharu Nakai, Kazuhiko Tsuboi, Atsushi Yamaguchi, Yasumasa Asamoto, Tomoji Nishioka, Minoru Sakomoto, Shigeyuki Yasumiba, Keishi Kanno, Yoshihiro Numata, Susumu Tazuma, Hidenori Ochi
Publikováno v:
Digestive Diseases and Sciences. 46:1285-1289
Sulfobromophthalein (BSP) is selectively taken up by the liver and secreted into the bile as unconjugated and conjugated forms. Our previous study demonstrated that unconjugated BSP, but not conjugated BSP, caused the dissociation of biliary lipid se
Publikováno v:
Digestive Diseases and Sciences. 45:2382-2391
The gallbladder role in cholesterol gallstone pathogenesis occurs through modulation of bile cholesterol metastability. The present study characterized the effects of concentrating bile on cholesterol crystallization through vesicle transformation, c
Autor:
Hidenori Ochi, Yasushi Sunami, Tsuyoshi Kajihara, Shigeyuki Yasumiba, Goro Kajiyama, Kuniharu Nakai, Gunji Yamashita, Kazuhiko Tsuboi, Yoshihiro Hattori, Hideyuki Hyogo, Yasumasa Asamoto, Minoru Sakomoto, Tomoji Nishioka, Susumu Tazuma
Publikováno v:
Digestive Diseases and Sciences. 45:1413-1421
Phospholipase A2 plays a role in cholesterol gallstone development by hydrolyzing bile phospholipids into lysolecithin and free fatty acids. Lysolecithin and polyunsaturated free fatty acids are known to stimulate the synthesis and/or secretion of ga
Autor:
Hiroaki Miyake, Taiji Matsumoto, Shigeyoshi Ohguri, Hiroyuki Miura, Toshiyuki Mizuno, Shigeyuki Yasumiba, Hidenori Ochi, Ken Adachi, Fumio Omata, Gunji Yamashita, Yasushi Sunami, Hisao Shibata, Goro Kajiyama, Fumiaki Ueno, Fumio Sugata, Tomoji Nishioka, Susumu Tazuma, Yoshihiro Hattori, Hideyuki Hyogo, Akio Abe, Tsuyoshi Kajihara, Shigehiro Kokubu
Publikováno v:
Journal of Clinical Gastroenterology. 26:287-291
Inhibitors of 3-hydroxy,3-methylglutaryl coenzyme A (HMG-CoA) reductase have been reported to decrease the cholesterol saturation index (CSI) in duodenal bile in humans and to prevent formation of cholesterol gallstones in animal studies. We performe
Autor:
Tomoji Nishioka, Hideyuki Hyogo, Hiroaki Miyake, Goro Kajiyama, Susumu Tazuma, Yasushi Sunami, Tsuyoshi Kajihara, Shigeyuki Yasumiba, Hiroyuki Miura, Gunji Yamashita, Yoshihiro Hattori, Hidenori Ochi
Publikováno v:
Clinical Therapeutics. 20:477-485
The use of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors has become common in the treatment of hypercholesterolemia. The present uncontrolled study was undertaken to determine the effect of cerivastatin sodium (BAY w 6228), a n
Autor:
Hideyuki Hyogo, Sumie Hatsushika, Susumu Tazuma, Gunji Yamashita, Tomoji Nishioka, Yasushi Sunami, Yoshihiro Hattori, Hiroaki Miyake, Hidenori Ochi, Hiroyuki Miura, Goro Kajiyama, Shigeyuki Yasumiba, Denya Tsuchimoto, Tsuyoshi Kajihara
Publikováno v:
Hepatology Research. 9:218-223
Lecithin–cholesterol vesicles are present in bile and play a role in cholesterol metastability. Cholesterol holding capacity of vesicles is regulated by lecithin hydrophobicity. In the present study, the effect of therapeutic bile salts on biliary
Publikováno v:
Biochimica et biophysica acta. 1532(1-2)
Phospholipase A(2) plays a role in cholesterol gallstone formation by hydrolyzing bile phospholipids into lysolecithin and free fatty acids. This study investigated its effects on cholesterol crystallization in model bile systems. Supersaturated mode
Autor:
Kuniharu Nakai, Hidenori Ochi, Goro Kajiyama, Yasushi Sunami, Hideyuki Hyogo, Susumu Tazuma, Yasumasa Asamoto, Tsuyoshi Kajihara, Kazuhiko Tsuboi, Minoru Sakomoto, Shigeyuki Yasumiba
Publikováno v:
Journal of clinical gastroenterology. 31(3)
Ninety-six patients treated successively for symptomatic cholelithiasis with extracorporeal shock wave lithotripsy (ESWL) and oral bile acid therapy consisting of ursodeoxycholic acid in daily dosages of 600 mg were prospectively followed for gallsto