Zobrazeno 1 - 10
of 106
pro vyhledávání: '"Yasushi Kishimoto"'
Autor:
Daiki Ojima, Yoko Tominaga, Takashi Kubota, Atsushi Tada, Hiroo Takahashi, Yasushi Kishimoto, Takashi Tominaga, Tohru Yamamoto
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 17, p 9674 (2024)
The maintenance of proper brain function relies heavily on the balance of excitatory and inhibitory neural circuits, governed in part by synaptic adhesion molecules. Among these, MDGA1 (MAM domain-containing glycosylphosphatidylinositol anchor 1) act
Externí odkaz:
https://doaj.org/article/405e26a81900415080a086f30c071b76
Autor:
Shoichi Tohyama, Yasushi Kishimoto
Publikováno v:
Data in Brief, Vol 47, Iss , Pp 108935- (2023)
Eyeblink conditioning is associated with motor learning, which requires the cerebellum and the brainstem. This article provides behavioral data on whether JNJ16259685, a selective metabotropic glutamate receptor type 1 (mGluR1) antagonist, affects ey
Externí odkaz:
https://doaj.org/article/c666b3b24a0045c1b5d849cbd112a462
Autor:
Kazuya Kuboyama, Yuki Shirakawa, Koji Kawada, Naoki Fujii, Daiki Ojima, Yasushi Kishimoto, Tohru Yamamoto, Maki K. Yamada
Publikováno v:
Neuropsychopharmacology Reports, Vol 40, Iss 4, Pp 371-375 (2020)
Abstract Aim Fear conditioning tests are intended to elucidate a subject's ability to associate a conditioned stimulus with an aversive, unconditioned stimulus, such as footshock. Among these tests, a paradigm related to precise cortical functions wo
Externí odkaz:
https://doaj.org/article/e8671a197b424b6d87d2d25e37221997
Publikováno v:
Data in Brief, Vol 36, Iss , Pp 107131- (2021)
We herein present behavioral data on whether memantine, an adamantane derivative and medical NMDA-receptor antagonist, improves spatial and latent learning deficits in amyloid precursor protein/presenilin 2 double-transgenic mice (PS2Tg2576 mice). In
Externí odkaz:
https://doaj.org/article/2130f2ff20024b6480d8746302a9b50f
Autor:
Maria Harbers, Harumi Nakao, Takaki Watanabe, Kyoko Matsuyama, Shoichi Tohyama, Kazuki Nakao, Yasushi Kishimoto, Masanobu Kano, Atsu Aiba
Publikováno v:
Cells, Vol 11, Iss 13, p 2004 (2022)
Group I metabotropic glutamate receptors (mGluRs) include mGluR1 and mGluR5, which are coupled to the Gq family of heterotrimeric G-proteins and readily activated by their selective agonist 3,5-dihydroxyphenilglycine (DHPG). mGluR1 and mGluR5 exhibit
Externí odkaz:
https://doaj.org/article/addd30c62fbf4d849ca120dfa65d33c9
Autor:
Yasushi Kishimoto, Ikuko Tsukamoto, Atsuko Nishigawa, Akiko Nishimoto, Yutaka Kirino, Yoshihisa Kato, Ryoji Konishi, Tokumi Maruyama, Norikazu Sakakibara
Publikováno v:
Data in Brief, Vol 20, Iss , Pp 1877-1883 (2018)
We herein present behavioral data regarding whether COA-Cl, a novel adenosine-like nucleic acid analog that promotes angiogenesis and features neuroprotective roles, improves cognitive and behavioral deficits in a murine model for Alzheimer׳s diseas
Externí odkaz:
https://doaj.org/article/41ad5ae4b5884665a4db9a8ef44f393c
Autor:
Steven A. Connor, Ina Ammendrup-Johnsen, Yasushi Kishimoto, Parisa Karimi Tari, Vedrana Cvetkovska, Takashi Harada, Daiki Ojima, Tohru Yamamoto, Yu Tian Wang, Ann Marie Craig
Publikováno v:
Cell Reports, Vol 21, Iss 13, Pp 3637-3645 (2017)
Synaptopathies contributing to neurodevelopmental disorders are linked to mutations in synaptic organizing molecules, including postsynaptic neuroligins, presynaptic neurexins, and MDGAs, which regulate their interaction. The role of MDGA1 in suppres
Externí odkaz:
https://doaj.org/article/9fc003b4b38d40e79f79de568050d0ed
Autor:
Yasushi Kishimoto, Hajime Shishido, Mayumi Sawanishi, Yasunori Toyota, Masaki Ueno, Takashi Kubota, Yutaka Kirino, Takashi Tamiya, Nobuyuki Kawai
Publikováno v:
Data in Brief, Vol 9, Iss C, Pp 62-67 (2016)
This data article contains supporting information regarding the research article entitled “Traumatic brain injury accelerates amyloid-β deposition and impairs spatial learning in the triple-transgenic mouse model of Alzheimer׳s disease” (H. Shi
Externí odkaz:
https://doaj.org/article/e79b79f49d2b412eb51901207fe7d9ac
Autor:
Hajime Shishido, Masaki Ueno, Kana Sato, Masahisa Matsumura, Yasunori Toyota, Yutaka Kirino, Takashi Tamiya, Nobuyuki Kawai, Yasushi Kishimoto
Publikováno v:
Behavioural Neurology, Vol 2019 (2019)
There has been growing awareness of the correlation between an episode of traumatic brain injury (TBI) and the development of Alzheimer’s disease (AD) later in life. It has been reported that TBI accelerated amyloid-β (Aβ) pathology and cognitive
Externí odkaz:
https://doaj.org/article/60558c7456a14b508d754068e3a5ec1b
Publikováno v:
International Journal of Alzheimer's Disease, Vol 2017 (2017)
Presenilin 1 and presenilin 2 (PS1 and PS2) play a critical role in γ-secretase-mediated cleavage of amyloid-β precursor protein (APP) and the subsequent generation of β-amyloid peptides. The purpose of the present study was to test whether PS2 mu
Externí odkaz:
https://doaj.org/article/4abd4f0423d8487dbbc9e7a964e1848e