Zobrazeno 1 - 10
of 249
pro vyhledávání: '"Yasushi Kawata"'
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-7 (2022)
Abstract Mid-infrared tunable coherent light sources are used in various laser applications, such as trace gas detection, laser processing, and biomedical diagnostics. This study demonstrates mid-infrared generation in the 8.3–11 µm (i.e., 900–1
Externí odkaz:
https://doaj.org/article/04cf443232aa45cd8ab03718ef362650
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-7 (2022)
Abstract The development of mid-infrared (mid-IR) tunable lasers has been driving various laser spectroscopic technologies. Herein, we report wavelength-scanning cavity ring-down spectroscopy (WS-CRDS) in the mid-IR region using an electronically tun
Externí odkaz:
https://doaj.org/article/87c0e98889fd40d6ae1c20f2b20c180e
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Many plants, including fruits and vegetables, release biogenic gases containing various volatile organic compounds such as ethylene (C2H4), which is a gaseous phytohormone. Non-destructive and in-situ gas sampling technology to detect trace
Externí odkaz:
https://doaj.org/article/481db8aa55434b9491cfa27727cf7440
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Aggregation of intrinsically disordered α-synuclein (αSN) under various conditions is closely related to synucleinopathies. Although various biological membranes have shown to alter the structure and aggregation propensity of αSN, a thorough under
Externí odkaz:
https://doaj.org/article/90699a88cc954f50991f81d453baaa44
Autor:
Masahiro Noji, Tatsushi Samejima, Keiichi Yamaguchi, Masatomo So, Keisuke Yuzu, Eri Chatani, Yoko Akazawa-Ogawa, Yoshihisa Hagihara, Yasushi Kawata, Kensuke Ikenaka, Hideki Mochizuki, József Kardos, Daniel E. Otzen, Vittorio Bellotti, Johannes Buchner, Yuji Goto
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-10 (2021)
Noji et al. test link between protein folding and misfolding upon heating and agitation. They show that folding and amyloid formation are separated by the supersaturation barrier of a protein, breakdown of which shifts the protein to the amyloid path
Externí odkaz:
https://doaj.org/article/ed4d8eeda119466189e820b1da445527
Autor:
Koki Furukawa, Cesar Aguirre, Masatomo So, Kenji Sasahara, Yohei Miyanoiri, Kazumasa Sakurai, Keiichi Yamaguchi, Kensuke Ikenaka, Hideki Mochizuki, Jozsef Kardos, Yasushi Kawata, Yuji Goto
Publikováno v:
Current Research in Structural Biology, Vol 2, Iss , Pp 35-44 (2020)
Proteins in either a native or denatured conformation often aggregate at an isoelectric point (pI), a phenomenon known as pI precipitation. However, only a few studies have addressed the role of pI precipitation in amyloid formation, the crystal-like
Externí odkaz:
https://doaj.org/article/a67334422dc445e68557bcef82563693
Autor:
Udin Bahrudin, Masaki Unno, Kazuya Nishio, Akiko Kita, Peili Li, Masaru Kato, Masashi Inoue, Shunichi Tsujitani, Takuto Murakami, Rina Sugiyama, Yasushi Saeki, Yuji Obara, Keiji Tanaka, Hiroshi Yamaguchi, Isao Sakane, Yasushi Kawata, Toshiyuki Itoh, Haruaki Ninomiya, Ichiro Hisatome, Yukio Morimoto
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
Abstract Local anesthetics (LAs) inhibit endoplasmic reticulum-associated protein degradation, however the mechanisms remain elusive. Here, we show that the clinically used LAs pilsicainide and lidocaine bind directly to the 20S proteasome and inhibi
Externí odkaz:
https://doaj.org/article/f5cdc61bc8ea4f0a8fc5652c9651c68c
Autor:
Ichiro Kawahata, Tomoki Sekimori, Haoyang Wang, Yanyan Wang, Toshikuni Sasaoka, Luc Bousset, Ronald Melki, Tomohiro Mizobata, Yasushi Kawata, Kohji Fukunaga
Publikováno v:
Biomedicines, Vol 9, Iss 1, p 49 (2021)
α-synuclein accumulation into dopaminergic neurons is a pathological hallmark of Parkinson’s disease. We previously demonstrated that fatty acid-binding protein 3 (FABP3) is critical for α-synuclein uptake and propagation to accumulate in dopamin
Externí odkaz:
https://doaj.org/article/9362381c280941d08bd134bce963f2fa
Autor:
Takehito Kondo, Ichiro Hisatome, Shouichi Yoshimura, Endang Mahati, Tomomi Notsu, Peili Li, Kazuhiko Iitsuka, Masaru Kato, Kazuyoshi Ogura, Junichiro Miake, Takeshi Aiba, Wataru Shimizu, Yasutaka Kurata, Shinji Sakata, Naoe Nakasone, Haruaki Ninomiya, Akira Nakai, Katsumi Higaki, Yasushi Kawata, Yasuaki Shirayoshi, Akio Yoshida, Kazuhiro Yamamoto
Publikováno v:
Journal of Arrhythmia, Vol 32, Iss 5, Pp 433-440 (2016)
Background: The human ether-a-go-go-related gene (HERG) encodes the α-subunit of rapidly activating delayed-rectifier potassium channels. Mutations in this gene cause long QT syndrome type 2 (LQT2). In most cases, mutations reduce the stability of t
Externí odkaz:
https://doaj.org/article/5d4db3e2c36644959f8332cdfd40f7fb
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e78135 (2013)
Kinetic analyses of GroE-assisted folding provide a dynamic sequence of molecular events that underlie chaperonin function. We used stopped-flow analysis of various fluorescent GroEL mutants to obtain details regarding the sequence of events that tra
Externí odkaz:
https://doaj.org/article/7cd65d9c339c4fd798e212db1bbb7947