Zobrazeno 1 - 10
of 270
pro vyhledávání: '"Yasushi FUJIO"'
Autor:
Masato Tanaka, Keisuke Shirakura, Yui Takayama, Miki Μatsui, Yukio Watanabe, Takuya Yamamoto, Junya Takahashi, Shota Tanaka, Nobumasa Hino, Takefumi Doi, Masanori Obana, Yasushi Fujio, Kazuo Takayama, Yoshiaki Okada
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-11 (2024)
Abstract Accumulating evidence suggests that endothelial cells can be useful therapeutic targets. One of the potential targets is an endothelial cell-specific protein, Roundabout4 (ROBO4). ROBO4 has been shown to ameliorate multiple diseases in mice,
Externí odkaz:
https://doaj.org/article/f65f16cb1f2c44ffb9e4bcea14555f44
Publikováno v:
Clinics and Practice, Vol 14, Iss 2, Pp 377-387 (2024)
Background: Avelumab, durvalumab, and atezolizumab are anti-programmed death-ligand 1 (PD-L1) antibodies approved for clinical application in Japan. Despite targeting the same molecule, avelumab elicits a different frequency of infusion-related react
Externí odkaz:
https://doaj.org/article/97d3072d0a814d10b52acb09e7fcf0db
Autor:
Hitomi Morihara, Tomomi Yamada, Yumi Tona, Marina Akasaka, Hirohisa Okuyama, Natsumi Chatani, Satomi Shinonome, Azumi Ueyama, Kenji Kuwabara, Yasushi Fujio
Publikováno v:
PLoS ONE, Vol 19, Iss 8, p e0305984 (2024)
Inhibiting the cytotoxic T-lymphocyte-associated protein-4 (CTLA-4)-mediated immune checkpoint system using an anti-CTLA-4 antibody (Ab) can suppress the growth of various cancers, but the detailed mechanisms are unclear. In this study, we establishe
Externí odkaz:
https://doaj.org/article/b1f8393907fc4471bd1ddd6927a36cd1
Autor:
Makiko Maeda, Douglas Humber, Eisuke Hida, Tomohito Ohtani, Guannan Wang, Tong Wu, Shiori Takeda, Jacinta N Situ, Jun Hayashi, Shinpei Nonen, Toshihiro Takeda, Hiroshi Okamoto, Masatsugu Hori, Yasushi Sakata, Yasushi Fujio, Shirley M Tsunoda
Publikováno v:
PLoS ONE, Vol 19, Iss 3, p e0299510 (2024)
The Japanese national guidelines recommend significantly lower doses of carvedilol for heart failure with reduced ejection fraction (HFrEF) management than the US guidelines. Using real-world data, we determined whether initial and target doses of ca
Externí odkaz:
https://doaj.org/article/79fb481803414b66a9eb4923f95b6ad4
Autor:
Shota Suzuki, Shota Tanaka, Yusuke Kametani, Ayaka Umeda, Kosuke Nishinaka, Kaho Egawa, Yoshiaki Okada, Masanori Obana, Yasushi Fujio
Publikováno v:
Physiological Reports, Vol 11, Iss 23, Pp n/a-n/a (2023)
Abstract Though it is well known that mammalian cardiomyocytes exit cell cycle soon after birth, the mechanisms that regulate proliferation remain to be fully elucidated. Recent studies reported that cardiomyocytes undergo dedifferentiation before pr
Externí odkaz:
https://doaj.org/article/f355cbf941614e85a796ac23eb016320
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Viral pneumonia is a global health burden with a high mortality rate, especially in the elderly and in patients with underlying diseases. Recent studies have found that myeloid-derived suppressor cells (MDSCs) are abundant in these patient groups; ho
Externí odkaz:
https://doaj.org/article/1150503fdf7748678a7316623385c4d2
Autor:
Masashi Tomimatsu, Kotaro Matsumoto, Moe Ashizuka, Shohei Kumagai, Shota Tanaka, Takafumi Nakae, Kosei Yokota, Shunsuke Kominami, Ryota Kajiura, Daisuke Okuzaki, Daisuke Motooka, Aki Shiraishi, Takaya Abe, Hideo Matsuda, Yoshiaki Okada, Makiko Maeda, Shigeto Seno, Masanori Obana, Yasushi Fujio
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Runt-related transcription factor 2 (Runx2), a regulator of osteoblast differentiation, is pathologically involved in vascular calcification; however, the significance of Runx2 in cardiac homeostasis remains unclear. Here, we investigated th
Externí odkaz:
https://doaj.org/article/08738451fb48478da9c64a09b48dcbfe
Autor:
Yoshiaki Miyake, Masanori Obana, Ayaha Yamamoto, Shunsuke Noda, Koki Tanaka, Hibiki Sakai, Narihito Tatsumoto, Chihiro Makino, Soshi Kanemoto, Go Shioi, Shota Tanaka, Makiko Maeda, Yoshiaki Okada, Kazunori Imaizumi, Katsuhiko Asanuma, Yasushi Fujio
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-14 (2022)
Upregulation of transcription factor OASIS in podocytes contributes to podocyte and/or tubular injury through decreased PRKCi expression and is a critical event for the disturbance of kidney homeostasis.
Externí odkaz:
https://doaj.org/article/75af94ef692343c8b537f31666d43232
Autor:
Tri Wahyuni, Shota Tanaka, Ryuta Igarashi, Yoshiaki Miyake, Ayaha Yamamoto, Shota Mori, Yusuke Kametani, Masashi Tomimatsu, Shota Suzuki, Kosei Yokota, Yoshiaki Okada, Makiko Maeda, Masanori Obana, Yasushi Fujio
Publikováno v:
Physiological Reports, Vol 10, Iss 9, Pp n/a-n/a (2022)
Abstract Tumor suppressor protein p53 plays crucial roles in the onset of heart failure. p53 activation results in cardiac dysfunction, at least partially by suppressing angiogenesis. Though p53 has been reported to reduce VEGF production by inhibiti
Externí odkaz:
https://doaj.org/article/cc3d276ec8364a32ac850e128525e956
Publikováno v:
Pharmacology Research & Perspectives, Vol 8, Iss 2, Pp n/a-n/a (2020)
Abstract Background and Purpose In cardiovascular diseases, cardiac fibroblasts (CFs) participate in the myocardial inflammation by producing pro‐inflammatory cytokines, worsening the prognosis. β2‐adrenergic receptor (AR) and β3AR are expresse
Externí odkaz:
https://doaj.org/article/53e57c500184411eb868fbd3b5b66d47