Výsledky vyhledávání - "Yasushi Aihara"

Homeobox Protein Hex Facilitates Serum Responsive Factor–Mediated Activation of the SM22α Gene Transcription in Embryonic Fibroblasts

Autor: Keiko Kawai-Kowase, Yoshio Ohyama, Yasushi Aihara, Ryozo Nagai, Mahito Sato, Tatsuya Iso, Yuko Oyama, Eichi Okamaoto, Hiroko Sato, Masahiko Kurabayashi, Kenichi Sekiguchi, Miki Yamazaki

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology. 24:1602-1607

Objective— Hex (hematopoietically expressed homeobox), a member of homeobox family of transcription factors, has been implicated in the vascular development because of its expression in hemangioblast, a hypothetical stem cell that gives rise to bot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7a5220e0d8ceaae59bbd3fe7462ec81
https://doi.org/10.1161/01.atv.0000138404.17519.45

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Transcriptional Activation of the BNP Gene by Lipopolysaccharide is Mediated Through GATA Elements in Neonatal Rat Cardiac Myocytes

Autor: Ryozo Nagai, Tomoyuki Yokoyama, Yasushi Aihara, Masahiko Kurabayashi, Kenichi Sekiguchi, Masashi Arai, Toru Tanaka, Kouichi Tomaru

Publikováno v: Journal of Molecular and Cellular Cardiology. 34:649-659

Lipopolysaccharide (LPS) has a profound effect on cardiac performance through a collapse of the vasculature. In this study, we determined whether LPS has a direct effect on the cardiac myocytes by examining the expression of the BNP gene in cultured

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d17e7dbc9753e9a02db93aba38d50928
https://doi.org/10.1006/jmcc.2002.2005

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Transforming Growth Factor-β/Smads Signaling Induces Transcription of the Cell Type–Restricted Ankyrin Repeat Protein CARP Gene Through CAGA Motif in Vascular Smooth Muscle Cells

Autor: Sin-ichi Takeda, Masahiko Kurabayashi, Kohei Miyazono, Ryozo Nagai, Yasushi Aihara, Hiroyoshi Kanai, Masahiro Kawabata, Toru Tanaka

Publikováno v: Circulation Research. 88:30-36

Abstract —Transforming growth factor (TGF)-β plays a major role in the development of vascular diseases. Despite the pleiotropic effects of TGF-β on vascular smooth muscle cells (VSMCs), only a few genes have been characterized as direct targets

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47b8f6812d271b22dfb728db18b2ed2d
https://doi.org/10.1161/01.res.88.1.30

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Induction of VEGF Gene Transcription by IL-1 is Mediated Through Stress-activated MAP Kinases and Sp1 Sites in Cardiac Myocytes

Autor: Ryozo Nagai, Masashi Arai, Masahiko Kurabayashi, T Kanda, Hiroyoshi Kanai, Yasushi Aihara, Kenichi Sekiguchi, Tomoyuki Yokoyama, Toru Tanaka

Publikováno v: Journal of Molecular and Cellular Cardiology. 32:1955-1967

Interleukin-1 beta (IL-1 beta) is a multipotent cytokine participating in a variety of cardiovascular diseases. In this study, we examined the effects of IL-1 beta on the expression of vascular endothelial cell growth factor (VEGF) and pursued the mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a49d3cffad54891cb35119ff347a5903
https://doi.org/10.1006/jmcc.2000.1228

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Doxorubicin Represses CARP Gene Transcription Through the Generation of Oxidative Stress in Neonatal Rat Cardiac Myocytes: Possible Role of Serine/Threonine Kinase-dependent Pathways

Autor: Shin-ichi Takeda, Toru Tanaka, Yoshio Ohyama, Yasushi Aihara, Masahiko Kurabayashi, Ryozo Nagai, Kouichi Tomaru, Kenichi Sekiguchi

Publikováno v: Journal of Molecular and Cellular Cardiology. 32:1401-1414

Doxorubicin (Dox), an anthracyclin antineoplastic agent, causes dilated cardiomyopathy. CARP has been identified as a nuclear protein whose mRNA levels are exquisitely sensitive to Dox. In this study we investigated the molecular mechanisms underlyin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86cf468511ff5aa77f82727afa97847f
https://doi.org/10.1006/jmcc.2000.1173

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Cardiac Ankyrin Repeat Protein Is a Novel Marker of Cardiac Hypertrophy

Autor: Masashi Arai, Kenichi Sekiguchi, Kouichi Tomaru, Shin-ichi Takeda, Yoshio Ohyama, Yuichiro Saito, Toru Tanaka, Yasushi Aihara, Masahiko Kurabayashi, Ryozo Nagai, Tetsuya Nakamura

Publikováno v: Hypertension. 36:48-53

Abstract —CARP, a cardiac doxorubicin (adriamycin)-responsive protein, has been identified as a nuclear protein whose expression is downregulated in response to doxorubicin. In the present study, we tested the hypothesis that CARP serves as a relia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7ece9c7391d1050a361ed73d90682a3
https://doi.org/10.1161/01.hyp.36.1.48

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Inducible Expression of Manganese Superoxide Dismutase by Phorbol 12-Myristate 13-Acetate Is Mediated by Sp1 in Endothelial Cells

Autor: Yasushi Aihara, Toru Tanaka, Ryozo Nagai, Yoshio Ohyama, Masahiko Kurabayashi

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology. 20:392-401

Abstract —The expression of manganese superoxide dismutase (Mn-SOD), an important component of the cellular defense system against oxidative stress, is induced in response to a variety of stimuli, including cytokines and phorbol esters, in endothel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5646eb804614fa04945f71fe9f330cc
https://doi.org/10.1161/01.atv.20.2.392

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