Zobrazeno 1 - 10
of 244
pro vyhledávání: '"Yasushi Abiko"'
Publikováno v:
In Japanese Journal of Pharmacology 1999 79(1):17-24
Autor:
Kazuto Yazawa, Min Chen, Chun-Yang Xiao, Hong Ma, Akiyoshi Hara, Hiroko Hashizume, Yasushi Abiko
Publikováno v:
Cardiovascular Drug Reviews. 15:335-353
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e03a305e673a90aa8d233a0197e8a201
https://doi.org/10.1111/j.1527-3466.1997.tb00340.x
https://doi.org/10.1111/j.1527-3466.1997.tb00340.x
Autor:
Kazuyasu Maruyama, Hisao Matsumura, Yasushi Abiko, Hiroko Hashizume, Akiyoshi Hara, Fumitaka Ushikubi
Publikováno v:
Cardiovascular Drug Reviews. 17:58-74
It has been generally accepted that the primary mechanism of action of antianginal drugs is the improvement of the myocardial oxygen balance between supply and demand in the ischemic heart, by either an increase in coronary flow or a decrease in card
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a5d2a186c45eefc1940098034a0c665
https://doi.org/10.1111/j.1527-3466.1999.tb00004.x
https://doi.org/10.1111/j.1527-3466.1999.tb00004.x
Publikováno v:
Journal of Pharmacy and Pharmacology. 52:709-715
The effect of ranolazine, a novel anti-ischaemic drug that stimulates the activity of pyruvate dehydrogenase, on palmitoyl-l-carnitine-induced mechanical dysfunction and metabolic derangement in isolated perfused rat hearts has been studied and compa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21206d183f3586f2d9da240ca58fda3f
https://doi.org/10.1211/0022357001774381
https://doi.org/10.1211/0022357001774381
Autor:
Fumitaka Ushikubi, Akiyoshi Hara, Yasushi Abiko, Johji Arakawa, Chun-Yang Xiao, Hiroko Hashizume
Publikováno v:
Journal of Pharmacy and Pharmacology. 51:1049-1058
The effect of tetrodotoxin, a specific inhibitor of the Na+ channel, and 5-(N,N-dimethyl)-amiloride, a specific inhibitor of the Na+/H+ exchanger, on the mechanical and metabolic derangements induced by hydrogen peroxide (H2O2) was studied in the iso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d376d578c6f8959730fc0ba442341932
https://doi.org/10.1211/0022357991773384
https://doi.org/10.1211/0022357991773384
Publikováno v:
European Journal of Pharmacology. 374:387-398
The effects of d -cis- and l -cis-diltiazem on the hydrogen peroxide (H2O2)-induced derangements of mechanical function and energy metabolism, and accumulation of intracellular Na+ were studied in isolated rat hearts. The intracellular concentration
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68ede0ad1ac8551d383e27206e9f450a
https://doi.org/10.1016/s0014-2999(99)00332-5
https://doi.org/10.1016/s0014-2999(99)00332-5
Autor:
Yasushi Abiko, Morris Karmazyn
How to protect against ischemia/reperfusion damage is one of the most urgent problems in medicine. It is known that ischemic damage can be attenuated by improving the oxygen balance of the ischemic heart, but the damage-producing mechanism is not yet
Publikováno v:
Japanese Journal of Pharmacology. 79:17-24
We examined the effects of quinaprilat, an active metabolite of quinapril (an angiotensin converting enzyme (ACE) inhibitor) on the increase in intracellular concentration of Ca2+ ([Ca2+]i) (Ca2+-overload) induced by lysophosphatidylcholine (LPC) in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3dca0f4b10ec4ccb1607e9a3bc3efd1
https://doi.org/10.1254/jjp.79.17
https://doi.org/10.1254/jjp.79.17
Autor:
Yasushi Abiko, Hiroko Hashizume
Publikováno v:
Folia Pharmacologica Japonica. 114:287-293
Lysophosphatidylcholine (LPC) is an amphiphilic metabolite produced from membrane-phospholipids by the activation of phospholipase A2 (PLA2), and it accumulates in the ischemic myocardium. It has been demonstrated that exogenous LPC produces an incre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fbd0fcae9fc49fa45742330a4c8c09e8
https://doi.org/10.1254/fpj.114.287
https://doi.org/10.1254/fpj.114.287
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 275:H1782-H1787
Lysophosphatidylcholine (LPC) is known to increase the intracellular concentration of Ca2+([Ca2+]i), leading to cell damage. In the present study we examined whether LPC activates phospholipase A2(PLA2) and whether the activation of PLA2is responsibl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb10063f442d6100137f0fad5e7638c1
https://doi.org/10.1152/ajpheart.1998.275.5.h1782
https://doi.org/10.1152/ajpheart.1998.275.5.h1782