Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Yasushi Yoshigae"'
Autor:
Takuya Miyano, Tsuyoshi Mikkaichi, Kouichi Nakamura, Yasushi Yoshigae, Kelly Abernathy, Yuji Ogura, Naoki Kiyosawa
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 8, p 4291 (2024)
Schizophrenia is a complex and heterogenous psychiatric disorder. This study aimed to demonstrate the potential of circulating microRNAs (miRNAs) as a clinical biomarker to stratify schizophrenia patients and to enhance understandings of their hetero
Externí odkaz:
https://doaj.org/article/29e9ea713ed94ab4b73b3850142bb0bd
Autor:
Tsuyoshi Mikkaichi, Noriko Okudaira, Takafumi Kato, Yoshiaki Matsumoto, Shuichi Ando, Takashi Izumi, Takako Shimizu, Yasushi Yoshigae
Publikováno v:
International journal of pharmaceutics. 597
The purpose of this study was to evaluate the impact of P-glycoprotein (P-gp) efflux on edoxaban absorption in gastrointestinal tracts quantitatively by a physiologically based pharmacokinetic (PBPK) model constructed with clinical and non-clinical o
Autor:
Tatsuya Inoue, Yoshitaka Isumi, Toshinori Agatsuma, Yasushi Yoshigae, Shinko Hayashi, Toshiyuki Sato, Jun Hasegawa
Publikováno v:
Translational Vision Science & Technology
Purpose Neovascular age-related macular degeneration (nAMD) results from choroidal neovascularization (CNV) and causes severe vision loss. Intravitreal anti-vascular endothelial growth factor (VEGF) therapies have significantly improved therapeutic o
Autor:
Yasushi Yoshigae, Tomoki Imaoka, Daisuke Nakai, Tsuyoshi Mikkaichi, Takashi Izumi, Noriko Okudaira
Publikováno v:
Drug Metabolism and Pharmacokinetics. 30:334-340
Organic anion transporting polypeptide (OATP) 1B1 and 1B3 are key molecules that are involved in hepatic uptake related to drug elimination, and OATP-mediated drug interactions are of clinical concern. In this study, with an aim to determine a cutoff
Publikováno v:
Drug Metabolism and Disposition. 41:1888-1895
Olmesartan medoxomil (OM) is a prodrug-type angiotensin II type 1 receptor blocker (ARB). We recently identified carboxymethylenebutenolidase homolog (CMBL) as the responsible enzyme for OM bioactivation in humans. In the present study, we compared t
Autor:
Takashi Izumi, Tomoko Ishizuka, Seiko Endo, Ayako Kato, Veronika Rozehnal, Atsushi Kurihara, Yasushi Yoshigae, Thomas Fischer
Publikováno v:
Drug Metabolism and Disposition. 41:1156-1162
Olmesartan medoxomil (OM) is a prodrug-type angiotensin II type 1 receptor antagonist. OM is rapidly converted into its active metabolite olmesartan by multiple hydrolases in humans, and we recently identified carboxymethylenebutenolidase homolog (CM
Autor:
Atsushi Kurihara, Tomoko Ishizuka, Takashi Izumi, Toshihiko Ikeda, Hidetaka Sakurai, Kaori Nakahara, Izumi Fujimori, Yasushi Yoshigae, Atsuko Nishida
Publikováno v:
Drug Metabolism and Disposition. 40:374-380
Olmesartan medoxomil (OM) is a prodrug-type angiotensin II type 1 receptor antagonist. The OM-hydrolyzing enzyme responsible for prodrug bioactivation was purified from human plasma through successive column chromatography and was molecularly identif
Autor:
Kyosuke Tanaka, Yoshiyuki Yabe, Atsushi Yamasaki, Koichi Nakamura, Nobuo Machinaga, Yasushi Yoshigae, Gary W. Ashley, Daniel V. Santi, Ralph Reid
Publikováno v:
Translational Vision Science & Technology
Purpose The short half lives of small molecules in the vitreous requires frequent repeated intravitreal injections that are impractical for treatment of chronic eye diseases. We sought to develop a method for increasing the intravitreal half-life of
Autor:
Ursula Höpner, Thomas Fischer, Akiko Okada, Naotoshi Yamamura, Kazuki Yano, Yasushi Yoshigae, Juergen Mueller, Osamu Okazaki, Motoko Saito-Yabe, Shinichi Mochizuki, Fumihiko Okada, Yuki Nagayama, Junichi Okada, Yukie Suzuki, Atsushi Kurihara, Yuji Kasuya, Masashi Honma, Toshihiko Ikeda, Silvia Zaja, Nao Fukuda, Eisuke Tsuda
Publikováno v:
Journal of Pharmacy and Pharmacology. 62:985-994
Objectives Our aim was to investigate the effect of PEGylation on the uptake of osteoprotegerin/osteoclastogenesis inhibitory factor (OPG/OCIF) into rat liver, kidney and spleen, and human liver. Methods Copolymer of polyethyleneglycol allylmethyleth
Autor:
Osamu Okazaki, Yasushi Yoshigae, Takashi Izumi, Atsushi Kurihara, Toshihiko Ikeda, Motoko Saito, Chisa Noji-Sakikawa, Izumi Fujimori, Mitsunori Kato, Kazuishi Kubota, Tomoko Ishizuka
Publikováno v:
The Journal of Biological Chemistry
Olmesartan medoxomil (OM) is a prodrug type angiotensin II type 1 receptor antagonist widely prescribed as an antihypertensive agent. Herein, we describe the identification and characterization of the OM bioactivating enzyme that hydrolyzes the prodr