Zobrazeno 1 - 10
of 389
pro vyhledávání: '"Yasushi, Sako"'
Publikováno v:
eLife, Vol 13 (2024)
Anionic lipid molecules, including phosphatidylinositol-4,5-bisphosphate (PI(4,5)P2), are implicated in the regulation of epidermal growth factor receptor (EGFR). However, the role of the spatiotemporal dynamics of PI(4,5)P2 in the regulation of EGFR
Externí odkaz:
https://doaj.org/article/a641cb139de54a92947c00397fc82d1a
Autor:
Nario Tomishige, Maaz Bin Nasim, Motohide Murate, Brigitte Pollet, Pascal Didier, Julien Godet, Ludovic Richert, Yasushi Sako, Yves Mély, Toshihide Kobayashi
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Although the human immunodeficiency virus type 1 lipid envelope has been reported to be enriched with host cell sphingomyelin and cholesterol, the molecular mechanism of the enrichment is not well understood. Viral Gag protein plays a centra
Externí odkaz:
https://doaj.org/article/d47d437a435648ef8bcd285b8043d31c
Autor:
Yukinobu Arata, Itsuki Shiga, Yusaku Ikeda, Peter Jurica, Hiroshi Kimura, Ken Kiyono, Yasushi Sako
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Fractal scaling in animal behavioral activity, where similar temporal patterns appear repeatedly over a series of magnifications among time scales, governs the complex behavior of various animal species and, in humans, can be altered by neur
Externí odkaz:
https://doaj.org/article/b2920abee1734abca357f0965090c35c
Autor:
Kouki Kawakami, Masataka Yanagawa, Suzune Hiratsuka, Misaki Yoshida, Yuki Ono, Michio Hiroshima, Masahiro Ueda, Junken Aoki, Yasushi Sako, Asuka Inoue
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
GPCR kinases (GRKs) phosphorylate active-form G-protein-coupled receptors (GPCRs). Here, the authors reveal that Gq heterotrimer coupled with the angiotensin II type-1 receptor (AT1R) determines the GRK subtypes recruited to the complex in a microdom
Externí odkaz:
https://doaj.org/article/2972418817ce44418cfb4f56c2c2f962
Autor:
Johannes N Wibisana, Takehiko Inaba, Hisaaki Shinohara, Noriko Yumoto, Tetsutaro Hayashi, Mana Umeda, Masashi Ebisawa, Itoshi Nikaido, Yasushi Sako, Mariko Okada
Publikováno v:
PLoS Genetics, Vol 18, Iss 6, p e1010235 (2022)
The transcription factor NF-κB, which plays an important role in cell fate determination, is involved in the activation of super-enhancers (SEs). However, the biological functions of the NF-κB SEs in gene control are not fully elucidated. We invest
Externí odkaz:
https://doaj.org/article/fb708160723745468d1971567fa785c1
Autor:
Nobuhisa Umeki, Keitaro Shibata, Taro Q. P. Noguchi, Keiko Hirose, Yasushi Sako, Taro Q. P. Uyeda
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Abstract Mutation of the Lys-336 residue of actin to Ile (K336I) or Asp (K336E) causes congenital myopathy. To understand the effect of this mutation on the function of actin filaments and gain insight into the mechanism of disease onset, we prepared
Externí odkaz:
https://doaj.org/article/47043d6050ef477ba9bafdcf76f063b1
Autor:
Yusuke Mii, Kenichi Nakazato, Chan-Gi Pack, Takafumi Ikeda, Yasushi Sako, Atsushi Mochizuki, Masanori Taira, Shinji Takada
Publikováno v:
eLife, Vol 10 (2021)
The mechanism of intercellular transport of Wnt ligands is still a matter of debate. To better understand this issue, we examined the distribution and dynamics of Wnt8 in Xenopus embryos. While Venus-tagged Wnt8 was found on the surfaces of cells clo
Externí odkaz:
https://doaj.org/article/1456326aa6b1485dbd3d910f39ceb896
Publikováno v:
Biophysics and Physicobiology, Vol 18 (2021)
RTK-RAS-MAPK systems are major signaling pathways for cell fate decisions. Among the several RTK species, it is known that the transient activation of ERK (MAPK) stimulates cell proliferation, whereas its sustained activation induces cell differentia
Externí odkaz:
https://doaj.org/article/fa88449db3214d69ab941949bc8a29cc
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Large scale live cell screens often lack single-molecule resolution. Here the authors present an artificial intelligence-assisted TIRF microscope with automated cell searching and focusing, and use it for high-throughput single-molecule imaging of EG
Externí odkaz:
https://doaj.org/article/5723c18bb18a45c18246cb484856bf35
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Abstract Mathematical modeling and analysis of biochemical reaction networks are key routines in computational systems biology and biophysics; however, it remains difficult to choose the most valid model. Here, we propose a computational framework fo
Externí odkaz:
https://doaj.org/article/82ad5b244fc04aa09dfb7172228676c1