Výsledky vyhledávání - "Yasushi, Hattori"

Akademický článek

Inhibition of KDM1A activity restores adult neurogenesis and improves hippocampal memory in a mouse model of Kabuki syndrome

Autor: Li Zhang, Genay Pilarowski, Emilio Merlo Pich, Atsushi Nakatani, John Dunlop, Rina Baba, Satoru Matsuda, Masaki Daini, Yasushi Hattori, Shigemitsu Matsumoto, Mitsuhiro Ito, Haruhide Kimura, Hans Tomas Bjornsson

Publikováno v: Molecular Therapy: Methods & Clinical Development, Vol 20, Iss , Pp 779-791 (2021)

Kabuki syndrome (KS) is a rare cause of intellectual disability primarily caused by loss-of-function mutations in lysine-specific methyltransferase 2D (KMT2D), which normally adds methyl marks to lysine 4 on histone 3. Previous studies have shown tha

Externí odkaz: https://doaj.org/article/6bb431629e2043e29d57edb98e0cfd0f

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Quantification of monoacylglycerol lipase and its occupancy by an exogenous ligand in rhesus monkey brains using [18F]T-401 and PET

Autor: Yuji Nagai, Jun Maeda, Makoto Higuchi, Kazunobu Aoyama, Takafumi Minamimoto, Yasushi Hattori, Tatsuki Koike, Ming-Rong Zhang, Chie Seki

Publikováno v: Journal of Cerebral Blood Flow & Metabolism. 42:656-666

Monoacylglycerol lipase (MAGL) is a cytosolic serine hydrolase that cleaves monoacylglycerols into fatty acids and is a potential target for the novel treatment of CNS disorders related to the endocannabinoid system and neuroinflammation. We have dev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a70a959dbbedf75887c84738e028a06a
https://doi.org/10.1177/0271678x211058285

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Design, Synthesis, and Evaluation of [18F]T-914 as a Novel Positron-Emission Tomography Tracer for Lysine-Specific Demethylase 1

Autor: Tohru Yamashita, Tatsuki Koike, Haruhide Kimura, Gilles Tamagnan, Kouta Matsumiya, Jumpei Aida, Olivier Barret, Yasushi Hattori, Paul McQuade, Satoru Matsuda, Christine M Sandiego, Alexandra Gouasmat, Vincent M. Carroll

Publikováno v: Journal of Medicinal Chemistry. 64:12680-12690

Histone methylation is associated with the pathophysiology of neurodevelopmental disorders. Lysine-specific demethylase 1 (LSD1) catalyzes histone demethylation in a flavin adenine dinucleotide (FAD)-dependent manner. Thus, inhibiting LSD1 enzyme act

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e9d128461b397c8eb721e36a82043d7b
https://doi.org/10.1021/acs.jmedchem.1c00653

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Design, Synthesis, and Evaluation of 11C-Labeled 3-Acetyl-Indole Derivatives as a Novel Positron Emission Tomography Imaging Agent for Diacylglycerol Kinase Gamma (DGKγ) in Brain

Autor: Tomohiro Ohashi, Tomoteru Yamasaki, Yasuyuki Debori, Tatsuki Koike, Tomokazu Kusumoto, Ryouta Maeda, Masayuki Fujinaga, Akito Hata, Takeshi Wakabayashi, Yasushi Hattori, Ming-Rong Zhang, Miyanohana Yuhei, Ryo Yamashita, Maki Miyamoto, Yiding Zhang, Hidekatsu Wakizaka

Publikováno v: Journal of Medicinal Chemistry. 64:11990-12002

Diacylglycerol kinase gamma (DGKγ) is a subtype of DGK enzyme, which catalyzes ATP-dependent conversion of diacylglycerol to phosphatidic acid. DGKγ, localized in the brain, plays an important role in the central nervous system. However, its functi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8fed7abf826a7d32a1858fd3c81b3bef
https://doi.org/10.1021/acs.jmedchem.1c00584

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Design, Synthesis, and Evaluation of (2-Aminocyclopropyl)phenyl Derivatives as Novel Positron Emission Tomography Imaging Agents for Lysine-Specific Demethylase 1 in the Brain

Autor: David Alagille, Satoru Matsuda, Rina Baba, Gilles Tamagnan, Thomas J. Morley, Yasushi Hattori, Tatsuki Koike, Caroline Papin, Cristian Constantinescu, Alexandra Gouasmat, Vincent M. Carroll, Shinji Iwasaki, Kouta Matsumiya

Publikováno v: Journal of Medicinal Chemistry. 64:3780-3793

Dysregulation of histone H3 lysine 4 (H3K4) methylation is implicated in the pathogenesis of neurodevelopmental disorders. Lysine-specific demethylase 1 (LSD1) determines the methylation status of H3K4 through flavin adenine dinucleotide (FAD)-mediat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db440a3e94e4141daeec35dfc6807678
https://doi.org/10.1021/acs.jmedchem.0c01937

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Design, synthesis, and structure-activity relationship of TAK-418 and its derivatives as a novel series of LSD1 inhibitors with lowered risk of hematological side effects

Autor: Yasushi Hattori, Shigemitsu Matsumoto, Shinji Morimoto, Masaki Daini, Masashi Toyofuku, Satoru Matsuda, Rina Baba, Koji Murakami, Misa Iwatani, Hideyuki Oki, Shinji Iwasaki, Kouta Matsumiya, Yusuke Tominari, Haruhide Kimura, Mitsuhiro Ito

Publikováno v: European journal of medicinal chemistry. 239

Lysine-specific demethylase 1 (LSD1) is an enzyme that demethylates methylated histone H3 lysine 4 (H3K4). Inhibition of LSD1 enzyme activity could increase H3K4 methylation levels and treat diseases associated with epigenetic dysregulation. However,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1799e4688154809d1d4f50bf466e86b
https://pubmed.ncbi.nlm.nih.gov/35749987

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Radiosynthesis and evaluation of 4-(6-[18F]Fluoro-4-(5-isopropoxy-1H-indazol-3-yl)pyridin-2-yl)morpholine as a novel radiotracer candidate targeting leucine-rich repeat kinase 2

Autor: Masayuki Hanyu, Yiding Zhang, Nobuki Nengaki, Wakana Mori, Hong Zhang, Yasushi Hattori, Katsushi Kumata, Tomoteru Yamasaki, Masayuki Fujinaga, Ming-Rong Zhang

Publikováno v: RSC Med Chem

Mutations that increase leucine-rich repeat kinase 2 (LRRK2) activity in the brain are associated with Parkinson's disease. Here, we synthesized a novel compound 4-(6-fluoro-4-(5-isopropoxy-1H-indazol-3-yl)pyridin-2-yl)morpholine (FIPM) and labeled i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d87d2af1d521d5ccdf1fd556dcda676c
https://doi.org/10.1039/c9md00590k

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Quantification of monoacylglycerol lipase and its occupancy by an exogenous ligand in rhesus monkey brains using [

Autor: Yasushi, Hattori, Chie, Seki, Jun, Maeda, Yuji, Nagai, Kazunobu, Aoyama, Ming-Rong, Zhang, Takafumi, Minamimoto, Tatsuki, Koike, Makoto, Higuchi

Publikováno v: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 42(4)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::585bafafc1d358acfbd0274b8307993f
https://pubmed.ncbi.nlm.nih.gov/34727758

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