Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Yasuro Sugimoto"'
Autor:
Robert W. Brueggemeier, Dwitiya B. Sawant, Yasuro Sugimoto, Somsundaram Chettiar, Michael V. Darby, Pui-Kai Li, Chenglong Li, Harold A. Fisk, Liguang Mao
Publikováno v:
Bioorganic & Medicinal Chemistry. 25:2156-2166
New targeted therapy approaches for certain subtypes of breast cancer, such as triple-negative breast cancers and other aggressive phenotypes, are desired. High levels of the mitotic checkpoint kinase Mps1/TTK have correlated with high histologic gra
Autor:
Suling Liu, Frans1, Yasuro Sugimoto, Frans1,2, Claudio Sorio, Frans3, Tecchio, Cristina3, Young C. Lin, Cristina1,2 lin.15@osu.edu
Publikováno v:
Oncogene. 2/12/2004, Vol. 23 Issue 6, p1256-1262. 7p. 6 Color Photographs, 1 Diagram, 8 Graphs.
Autor:
Bryant C. Yung, Lesheng Teng, Robert J. Lee, Robert W. Brueggemeier, Hong Li, Yasuro Sugimoto, Longzhu Piao
Publikováno v:
Nanomedicine: Nanotechnology, Biology and Medicine. 9:122-129
Human serum albumin (HSA)-coated lipid nanoparticles (HSA-LNPs) loaded with phrGFP-targeted siRNA (HSA-LNPs-siRNA) were prepared and evaluated for gene downregulation effect in phrGFP-transfected breast cancer cells and the corresponding xenograft tu
Autor:
Finn Bauer, Robert W. Brueggemeier, Robert J. Lee, Megan Cavanaugh Terp, Yasuro Sugimoto, Bo Yu, L. James Lee
Publikováno v:
International Journal of Pharmaceutics. 430:328-334
DOTAP, as a racemic mixture, is a cationic lipid and a widely used transfection reagent. In this study, the effect of DOTAP’s stereochemical structure on transfection efficiency was evaluated in vitro. Racemic and enantiomerically pure DOTAP were u
Autor:
Yicheng Mao, Chenguang Zhou, Robert W. Brueggemeier, Yasuro Sugimoto, Bo Yu, Robert J. Lee, Naveen Kanthamneni, Yue Zhang, L. James Lee
Publikováno v:
Molecular Pharmaceutics. 9:201-210
Nonionic surfactant vesicles, or SPANosomes (SPs), comprised of cationic lipid and sorbitan monooleate (Span 80) were synthesized and evaluated as small interfering RNA (siRNA) vectors. The SPs had a mean diameter of less than 100 nm and exhibited ex
Autor:
Robert W. Brueggemeier, Edgar S. Díaz-Cruz, Priscilla A. Furth, G. Ian Gallicano, Yasuro Sugimoto
Publikováno v:
Cancer Research. 71:5477-5487
Factors associated with increased estrogen synthesis increase breast cancer risk. Increased aromatase and estrogen receptor α (ERα) in both normal epithelium and ductal carcinoma in situ lesions are found in conjunction with breast cancer, leading
Autor:
Stephen P. Povoski, Rachel M. Layman, Amy Lehman, Donna R. Shiels, Robert W. Brueggemeier, Ewa Mrozek, Rebecca Ziegler, Charles L. Shapiro, Amy S. Ruppert, Yasuro Sugimoto, Weiqiang Zhao, Bhuvaneswari Ramaswamy, Maryam B. Lustberg
Publikováno v:
Clinical Breast Cancer. 11:221-227
Within breast tissue, aromatase expression and activity is increased by prostaglandin E2, providing a rationale for combining the COX-2 inhibitor celecoxib with an aromatase inhibitor. To evaluate the effect of these drugs on aromatase and other biom
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 118:207-210
Aromatase is a particularly attractive drug target in the treatment of hormone-responsive breast cancer, and aromatase activity in breast cancer patients is greater in or near the tumor tissue compared with the normal breast tissue. Complex regulatio
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 106:16-23
Aromatase expression and enzyme activity in breast cancer patients is greater in or near the tumor tissue compared with the normal breast tissue. Complex regulation of aromatase expression in human tissues involves alternative promoter sites that pro
Autor:
Yasuro Sugimoto, Sherry Shu, Hsiang-Lin Chang, Weiping Ye, Young C. Lin, Yi-Wen Huang, Li-Shu Wang
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 100:24-33
In normal prostate, keratinocyte growth factor (KGF), also known as fibroblast growth factor-7 (FGF-7) serves as a paracrine growth factor synthesized in stromal cells that acts on epithelial cells through its receptor, KGFR. KGF and KGFR were found