Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Yasuro Kawaguchi"'
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 31:47-55
A liquid chromatographic-electrospray ionization tandem mass spectrometric (LC-ESI/MS/MS) method was developed for the quantitative analysis of a novel anticancer drug, 3'-C-ethynylcytidine (I) in human plasma and urine. I and its stable isotope-labe
Autor:
Kazuho Okudaira, Masahiro Hayashi, Hiroshi Kiwada, Ryotaro Azuma, Yasuro Kawaguchi, Masahito Komuro
Publikováno v:
Drug Metabolism and Pharmacokinetics. 17:75-82
Summary: To clarify the cause of the canine individual variability in plasma concentration after oral administration of GTS-21, we evaluated in vitro the metabolism to 4-OH-GTS-21 in liver microsomes of the same individuals from in vivo pharmacokinet
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 754:113-119
During the development of the liquid chromatography with electrospray ionization-tandem mass spectrometry for the quantitative determination of 3'-C-ethynylcytidine (I) in rat plasma, ion suppression caused by the matrix components was observed for I
Autor:
Kazue Hironaga, Kunihiro Yoshisue, Syuji Yamaguchi, Yasuro Kawaguchi, Akira Yamamoto, Sekio Nagayama
Publikováno v:
Cancer Chemotherapy and Pharmacology. 46:51-56
Purpose: An important cytotoxic effect of 5-fluorouracil (5-FU) is the inactivation of thymidylate synthase (TS) (EC 2.1.1.45) activity by the formation of a ternary complex consisting of covalently bound 5-fluorodeoxyuridine 5′-monophosphate (FdUM
Autor:
Yasuro Kawaguchi, Kenichiro Ogura, Tadashi Watabe, Takahito Nishiyama, Masakazu Fukushima, Hiroaki Takubo, Haruhiro Okuda, Atsushi Kato, Kazuhito Arakawa, Sekio Nagayama
Publikováno v:
Cancer Letters. 122:107-113
An enzymatic study was performed to clarify the mechanism of 18 acute deaths in patients who had received the new oral antiviral drug, sorivudine (SRV), during anticancer chemotherapy with 5-fluorouracil (5-FU) prodrugs. Human dihydropyrimidine dehyd
Autor:
Yasuro Kawaguchi, Katsuyuki Hori, Hirotoshi Masuda, Sekio Nagayama, Yoshio Esumi, Toshiyuki Mashiko
Publikováno v:
Drug Metabolism and Pharmacokinetics. 12:355-386
S-1, a new oral anti-cancer drug, is composed of tegafur (FT), gimestat (CDHP) and potassium otastat (Oxo) in a molar ratio of 1 : 0.4 : 1. FT which is masked compound of 5-fluorouracil (5-FU) plays a role as an effector. Both CDHP and Oxo which do n
Autor:
Toshiyuki Mashiko, Yasuro Kawaguchi, Hirotoshi Masuda, Katsuyuki Hori, Sekio Nagayama, Yoshio Esumi
Publikováno v:
Drug Metabolism and Pharmacokinetics. 12:332-354
S-1, a new oral anti-cancer drug, is composed of tegafur (FT), gimestat (CDHP) and potassium otastat (Oxo) in a molar ratio of 1 : 0.4 : 1. FT which is masked compound of 5-fluorouracil (5-FU) plays a role as an effector. Both CDHP and Oxo which do n
Autor:
Katsuyuki Hori, Yasuro Kawaguchi, Hirotoshi Masuda, Kisako Toko, Toshiyuki Mashiko, Sekio Nagayama, Yoshio Esumi
Publikováno v:
Drug Metabolism and Pharmacokinetics. 12:301-321
S-1, a new oral anti-cancer drug, is composed of tegafur(FT), gimestat(CDHP) and potassium otastat(Oxo) in a molar ratio of 1 : 0.4 : 1. FT which is masked compound of 5-fluorouracil (5-FU) plays a role as an effector. Both CDHP and Oxo which do not
Disposition of Components of New Anti-cancer Drug S-1 (8): Species Differences, Dose Proportionality
Autor:
Eiji Matsushima, Sekio Nagayama, Yasuro Kawaguchi, Hirotoshi Masuda, Kisako Toko, Kazumasa Ikeda, Kunihiro Yoshisue
Publikováno v:
Drug Metabolism and Pharmacokinetics. 12:656-667
S-1, a new oral anti-cancer drug, is composed of 5-fluoro-1-(tetrahydro-2-furanyl)-2, 4(1H, 3H)-pyrimidinedione (tegafur: FT), 5-chloro-2, 4-dihydroxypyridine (gimestat: CDHP) and potassium 1, 2, 3, 4-tetrahydro-2, 4-dioxo-1, 3, 5-triazine-6-carboxyl
Autor:
Sekio Nagayama, Ryotaro Azuma, Kisako Toko, Kazumasa Ikeda, Yoshio Yamamoto, Yasuro Kawaguchi, Eiji Matsushima
Publikováno v:
Drug Metabolism and Pharmacokinetics. 12:630-644