Zobrazeno 1 - 10
of 741
pro vyhledávání: '"Yasuo WATANABE"'
Autor:
Ryoken Aoki, Yasuo Watanabe, Yuki Sakai, Megumi Furukawa, Takahiro Shigetomi, Chen Jiun Rong, Nobuo Izumo
Publikováno v:
Current Research in Food Science, Vol 8, Iss , Pp 100713- (2024)
Sparassis crispa, an edible mushroom, has been reported to show many kinds of physiological functions. The present paper focused on reducing body weight, subcutaneous fat, and visceral fat gain in ovariectomized (OVX) mice. Using the fruiting body po
Externí odkaz:
https://doaj.org/article/00a82981569044da8303cafcea2c4d66
Autor:
Honami Echizen, Kenjiro Hanaoka, Kazuhito Shimamoto, Ryota Hibi, Sachiko Toma-Fukai, Hisashi Ohno, Eita Sasaki, Toru Komatsu, Tasuku Ueno, Yukihiro Tsuchiya, Yasuo Watanabe, Takao Otsuka, Hiroaki Saito, Satoru Nagatoishi, Kouhei Tsumoto, Hirotatsu Kojima, Takayoshi Okabe, Toshiyuki Shimizu, Yasuteru Urano
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract D,L-Propargylglycine (PAG) has been widely used as a selective inhibitor to investigate the biological functions of cystathionine γ-lyase (CSE), which catalyzes the formation of reactive sulfur species (RSS). However, PAG also inhibits othe
Externí odkaz:
https://doaj.org/article/90eed93fe0d34640b472dbfd8bff78fa
Autor:
Shoma Araki, Tsuyoshi Takata, Katsuhiko Ono, Tomohiro Sawa, Shingo Kasamatsu, Hideshi Ihara, Yoshito Kumagai, Takaaki Akaike, Yasuo Watanabe, Yukihiro Tsuchiya
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 12, p 9982 (2023)
Cystathionine γ-lyase (CSE) is an enzyme responsible for the biosynthesis of cysteine from cystathionine in the final step of the transsulfuration pathway. It also has β-lyase activity toward cystine, generating cysteine persulfide (Cys-SSH). The c
Externí odkaz:
https://doaj.org/article/75198ecd49074b038111f2ea4ea8155b
Autor:
Koji Osuka, Yusuke Ohmichi, Mika Ohmichi, Satoru Honma, Chiharu Suzuki, Masahiro Aoyama, Kenichiro Iwami, Yasuo Watanabe, Shigeru Miyachi
Publikováno v:
Biomedicines, Vol 11, Iss 5, p 1440 (2023)
Background: A chronic subdural hematoma (CSDH) is considered to be an inflammatory and angiogenic disease. The CSDH outer membrane, which contains inflammatory cells, plays an important role in CSDH development. Osteopontin (OPN) is an extracellular
Externí odkaz:
https://doaj.org/article/64bc4b7fae374b4c8d32515e59852def
Autor:
Shotaro Kamata, Takuji Oyama, Kenta Saito, Akihiro Honda, Yume Yamamoto, Keisuke Suda, Ryo Ishikawa, Toshimasa Itoh, Yasuo Watanabe, Takahiro Shibata, Koji Uchida, Makoto Suematsu, Isao Ishii
Publikováno v:
iScience, Vol 23, Iss 11, Pp 101727- (2020)
Summary: Most triacylglycerol-lowering fibrates have been developed in the 1960s–1980s before their molecular target, peroxisome proliferator-activated receptor alpha (PPARα), was identified. Twenty-one ligand-bound PPARα structures have been dep
Externí odkaz:
https://doaj.org/article/019e9a2e669140bd9f38f82355fbf354
Autor:
Koji Osuka, Yasuo Watanabe, Nobuteru Usuda, Kenichiro Iwami, Shigeru Miyachi, Masakazu Takayasu
Publikováno v:
PLoS ONE, Vol 15, Iss 6, p e0233643 (2020)
Chronic subdural hematoma (CSDH) is an angiogenic and inflammatory disease. Toll-like receptors (TLRs) transduce intracellular signals, resulting in the activation of nuclear factor κB (NF-κB), which leads to the production of inflammatory cytokine
Externí odkaz:
https://doaj.org/article/f021e897b5d645469916e2ac96233773
Autor:
Takaaki Akaike, Tomoaki Ida, Fan-Yan Wei, Motohiro Nishida, Yoshito Kumagai, Md. Morshedul Alam, Hideshi Ihara, Tomohiro Sawa, Tetsuro Matsunaga, Shingo Kasamatsu, Akiyuki Nishimura, Masanobu Morita, Kazuhito Tomizawa, Akira Nishimura, Satoshi Watanabe, Kenji Inaba, Hiroshi Shima, Nobuhiro Tanuma, Minkyung Jung, Shigemoto Fujii, Yasuo Watanabe, Masaki Ohmuraya, Péter Nagy, Martin Feelisch, Jon M. Fukuto, Hozumi Motohashi
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Cysteine hydropersulfides (CysSSH) are believed to have a cellular redox protective role. Here the authors show that these species can be produced from L-cysteine by cysteinyl-tRNA synthetases and that these enzymes are also involved in mitochondrial
Externí odkaz:
https://doaj.org/article/59355d393d744dc18b1812f57d180eae
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 22, p 8750 (2020)
Reactive oxygen species (ROS) are not only harmful to cell survival but also essential to cell signaling through cysteine-based redox switches. In fact, ROS triggers the potential activation of mitogen-activated protein kinases (MAPKs). The 90 kDa ri
Externí odkaz:
https://doaj.org/article/a9b1b4320424438db008777a428f9202
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 21, p 7997 (2020)
Ca2+/calmodulin (CaM)-dependent protein kinase II (CaMKII) is highly abundant in the brain and exhibits broad substrate specificity, thereby it is thought to participate in the regulation of neuronal death and survival. Nitric oxide (NO), produced by
Externí odkaz:
https://doaj.org/article/90ce529593024d18b15b870ed49390dc
Publikováno v:
Nutrients, Vol 12, Iss 2, p 455 (2020)
The purpose of this study was to investigate whether or not Coriandrum sativum seed extract (CSSE) can ameliorate memory impairment in senescence-accelerated mouse-prone 8 (SAMP8) mice. Sixteen 10-week-old male SAMP8 mice were divided into two groups
Externí odkaz:
https://doaj.org/article/6493ab20400045a9b6ae0c17c38c79ee