Zobrazeno 1 - 10
of 432
pro vyhledávání: '"Yasuo Ohno"'
Autor:
Yuchen Sun, Kosuke Saito, Atsuhito Ushiki, Mitsuhiro Abe, Yoshinobu Saito, Takeru Kashiwada, Yasushi Horimasu, Akihiko Gemma, Koichiro Tatsumi, Noboru Hattori, Kenji Tsushima, Kazuhisa Takemoto, Rika Ishikawa, Toshiko Momiyama, Shin-ichiro Matsuyama, Noriaki Arakawa, Hirotoshi Akane, Takeshi Toyoda, Kumiko Ogawa, Motonobu Sato, Kazuhiko Takamatsu, Kazuhiko Mori, Takayoshi Nishiya, Takashi Izumi, Yasuo Ohno, Yoshiro Saito, Masayuki Hanaoka
Publikováno v:
Respiratory Research, Vol 25, Iss 1, Pp 1-23 (2024)
Abstract Background Drug-induced interstitial lung disease (DILD) is a lung injury caused by various types of drugs and is a serious problem in both clinical practice and drug development. Clinical management of the condition would be improved if the
Externí odkaz:
https://doaj.org/article/1318948710974ad7a181c0d83d189e4d
Autor:
Kosuke Saito, Akihiko Gemma, Koichiro Tatsumi, Noboru Hattori, Atsuhito Ushiki, Kenji Tsushima, Yoshinobu Saito, Mitsuhiro Abe, Yasushi Horimasu, Takeru Kashiwada, Kazuhiko Mori, Motonobu Sato, Takayoshi Nishiya, Kazuhiko Takamatsu, Yuchen Sun, Noriaki Arakawa, Takashi Izumi, Yasuo Ohno, Yoshiro Saito, Masayuki Hanaoka
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Drug-induced interstitial lung disease (DILD) occurs when drug exposure causes inflammation of the lung interstitium. DILD can be caused by different types of drugs, and some DILD patterns results in a high mortality rate; hence, DILD poses
Externí odkaz:
https://doaj.org/article/0c7f20c00a684773a7c25ae7391cf65d
Autor:
Noriaki Arakawa, Atsuhito Ushiki, Mitsuhiro Abe, Shinichiro Matsuyama, Yoshinobu Saito, Takeru Kashiwada, Yasushi Horimasu, Akihiko Gemma, Koichiro Tatsumi, Noboru Hattori, Kenji Tsushima, Keiko Miyashita, Kosuke Saito, Ryosuke Nakamura, Takeshi Toyoda, Kumiko Ogawa, Motonobu Sato, Kazuhiko Takamatsu, Kazuhiko Mori, Takayoshi Nishiya, Takashi Izumi, Yasuo Ohno, Yoshiro Saito, Masayuki Hanaoka
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
No reliable serum biomarker for diffuse alveolar damage, a poor prognosis subtype of drug-induced interstitial lung disease, is currently available. Here, the authors show stratifin/14-3-3σ in serum is a promising biomarker for diagnosis of this typ
Externí odkaz:
https://doaj.org/article/26c767ba6b984eb3ba31e8f03b45e8ce
Autor:
Atsuko Miyajima, Yukie Kuroda, Kazue Sakemi-Hoshikawa, Makoto Usami, Katsuyoshi Mitsunaga, Tomohiko Irie, Yasuo Ohno, Momoko Sunouchi
Publikováno v:
Toxicology Reports, Vol 7, Iss , Pp 979-985 (2020)
Effects of 4-methyl-2-mercaptobenzimidazole (4-MeMBI) and 5-methyl-2- mercaptobenzimidazole (5-MeMBI) on cytochrome P450 (CYP) activity were examined in primary cultured rat hepatocytes. Hepatocytes from male Wistar rats were cultured in the presence
Externí odkaz:
https://doaj.org/article/2baa9904a5d44238b2664d345c8d630b
Autor:
Kosuke Saito, Tatehiro Kagawa, Keiji Tsuji, Yuji Kumagai, Ken Sato, Shotaro Sakisaka, Naoya Sakamoto, Mitsuhiko Aiso, Shunji Hirose, Nami Mori, Rieko Tanaka, Toshio Uraoka, Kazuhide Takata, Koji Ogawa, Kazuhiko Mori, Motonobu Sato, Takayoshi Nishiya, Kazuhiko Takamatsu, Noriaki Arakawa, Takashi Izumi, Yasuo Ohno, Yoshiro Saito, Hajime Takikawa
Publikováno v:
Metabolites, Vol 10, Iss 9, p 355 (2020)
Drug-induced liver injury (DILI) is a major adverse event caused by drug treatment, which can be categorized into three types: hepatocellular, mixed, and cholestatic. Although nearly every class of drugs can cause DILI, an overall understanding of li
Externí odkaz:
https://doaj.org/article/fb4ff2dbe5c84f8e8d0740efbb71510a
Publikováno v:
IEEE Journal of the Electron Devices Society, Vol 2, Iss 6, Pp 168-173 (2014)
GaN Schottky barrier diodes (SBDs) with low turn-on voltage are developed for microwave rectification. The diodes with reactively-sputtered TiN electrodes have a lower turn-on voltage compared with the diodes with Ni electrode, while the on-resistanc
Externí odkaz:
https://doaj.org/article/808b7c4fcacf46a397f37430d7e1f572
Autor:
Takuo Suzuki, Norimasa Tamehiro, Yoji Sato, Tetsu Kobayashi, Akiko Ishii-Watabe, Youichi Shinozaki, Tomoko Nishimaki-Mogami, Toshihiro Hashimoto, Yoshinori Asakawa, Kazuhide Inoue, Yasuo Ohno, Teruhide Yamaguchi, Toru Kawanishi
Publikováno v:
Journal of Pharmacological Sciences, Vol 107, Iss 3, Pp 285-294 (2008)
Farnesoid X receptor (FXR) controls the expression of critical genes in bile acid and cholesterol homeostasis. To study FXR and to develop a regulator of cholesterol, some nonsteroidal and steroidal ligands have been found in addition to endogenous l
Externí odkaz:
https://doaj.org/article/54ff935b5140480fbae8dfdb6020a717
Autor:
Ken Nakazawa, Yasuo Ohno
Publikováno v:
Journal of Pharmacological Sciences, Vol 93, Iss 1, Pp 118-121 (2003)
ABSTRACT: The effects of phytoestrogens on neuronal nicotinic acetylcholine receptor/channels were examined by expressing recombinant channels in Xenopus oocytes. When functional channels were expressed with human α4 and β2 subuints, daidzein (10 a
Externí odkaz:
https://doaj.org/article/8be84c1a3f864796bd4e3b97371c07b5
Autor:
Masanori Sakimura, Akira Tsukada, Makoto Usami, Shozo Hanzawa, Noboru Saito, Yasuo Ohno, Kiyoshi Shimada
Publikováno v:
The Journal of Poultry Science, Vol 39, Iss 4, Pp 302-309 (2002)
Effects of estradiol-17β (E2) and p-nonylphenol (NP) on mRNA expression of estrogen receptor α (ERα), estrogen receptor β (ERβ) and cytochrome P450 aromatase (P450arom) were examined in the early stage of chicken embryonic gonads. Fertilized egg
Externí odkaz:
https://doaj.org/article/d11660fa545d4de5b0745a1108a03156
Autor:
Masanori Sakimura, Makoto Usami, Shozo Hanzawa, Akira Tsukada, Noboru Saito, Yasuo Ohno, Kiyoshi Shimada
Publikováno v:
The Journal of Poultry Science, Vol 39, Iss 2, Pp 91-99 (2002)
Effects of estradiol-17β (E2) and p-nonylphenol (NP) on the mRNA expression of sex determination-related genes were examined in the embryonic gonad of chickens. Fertilized eggs were treated with either E2 (0.1 and 1.0 mg/egg) or NP (0.001, 0.01, 0.1
Externí odkaz:
https://doaj.org/article/61ad3c24be524bd9a61d9062091cb6cd