Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Yasuo Oguri"'
Autor:
Futoshi Furuya, Yoshihito Fujita, Naomi Matsuo, Hiroto Minamino, Yasuo Oguri, Nozomi Isomura, Kaori Ikeda, Kohei Takesue, Ying Li, Aki Kondo, Fumika Mano, Nobuya Inagaki
Publikováno v:
EBioMedicine, Vol 86, Iss , Pp 104342- (2022)
Summary: Background: Sodium glucose co-transporter 2 (SGLT2) inhibitors are anti-diabetic drugs for type 2 diabetes that lower blood glucose levels and body weight. It is of special interest that SGLT2 inhibitors also improve liver metabolism and fat
Externí odkaz:
https://doaj.org/article/53756e734db4494697f810791fc22211
Autor:
Hiroto Minamino, Masao Katsushima, Motomu Hashimoto, Yoshihito Fujita, Tamami Yoshida, Kaori Ikeda, Nozomi Isomura, Yasuo Oguri, Wataru Yamamoto, Ryu Watanabe, Kosaku Murakami, Koichi Murata, Kohei Nishitani, Masao Tanaka, Hiromu Ito, Koichiro Ohmura, Shuichi Matsuda, Nobuya Inagaki, Akio Morinobu
Publikováno v:
Arthritis Research & Therapy, Vol 23, Iss 1, Pp 1-10 (2021)
Abstract Background Excessive salt intake is thought to exacerbate both development of hypertension and autoimmune diseases in animal models, but the clinical impact of excessive salt in rheumatoid arthritis (RA) patients is still unknown. We perform
Externí odkaz:
https://doaj.org/article/48a0dff875d841d6b595840a84f3aa41
Autor:
Sneha Damal Villivalam, Dongjoo You, Jinse Kim, Hee Woong Lim, Han Xiao, Pete-James H. Zushin, Yasuo Oguri, Pouya Amin, Sona Kang
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Epigenetic regulators contribute to the modulation of adipose thermogenesis by sensing environmental cues and regulating gene expression in response. Here the authors report that a DNA demethylase TET1 mediates epigenetic changes to repress thermogen
Externí odkaz:
https://doaj.org/article/4797aed5ec144f80886437b84bb7f261
Autor:
Kazuki Tajima, Kenji Ikeda, Yuji Tanabe, Ella A. Thomson, Takeshi Yoneshiro, Yasuo Oguri, Marc D. Ferro, Ada S. Y. Poon, Shingo Kajimura
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Cardiovascular risks of cold exposure and the subsequent activation of the β3-AR pathway limit the application of beige fat thermogenesis for the treatment of obesity. Here, the authors show that optogenetics light-activated Ca2+ cycling in adipocyt
Externí odkaz:
https://doaj.org/article/c6fe438eef6244abb2103d07bbb951d4
Autor:
Hiroto Minamino, Masao Katsushima, Motomu Hashimoto, Yoshihito Fujita, Mie Torii, Kaori Ikeda, Nozomi Isomura, Yasuo Oguri, Wataru Yamamoto, Ryu Watanabe, Kosaku Murakami, Koichi Murata, Kohei Nishitani, Masao Tanaka, Hiromu Ito, Miyabi Uda, Kazuko Nin, Hidenori Arai, Shuichi Matsuda, Akio Morinobu, Nobuya Inagaki
Publikováno v:
PLoS ONE, Vol 16, Iss 8 (2021)
Objective Although mental disorder is one of the most common comorbidities of rheumatoid arthritis (RA) and is known as a critical influence on RA remission rates, there is little knowledge regarding a possible therapeutic strategy for depression or
Externí odkaz:
https://doaj.org/article/e427c2a7920a4a25a4fdf423920dbedf
Autor:
Ichitaro Abe, Yasuo Oguri, Anthony R.P. Verkerke, Lauar B. Monteiro, Carly M. Knuth, Christopher Auger, Yunping Qiu, Gregory P. Westcott, Saverio Cinti, Kosaku Shinoda, Marc G. Jeschke, Shingo Kajimura
Publikováno v:
Developmental cell. 57(23)
De novo beige adipocyte biogenesis involves the proliferation of progenitor cells in white adipose tissue (WAT); however, what regulates this process remains unclear. Here, we report that in mouse models but also in human tissues, WAT lipolysis-deriv
Autor:
Yasuo Oguri, Shingo Kajimura, Ralph J. DeBerardinis, Supna Nair, Kenji Ikeda, Ryan M. Gill, Juan A. Oses-Prieto, Alma L. Burlingame, Davide Ruggero, Harrison J. Tom, Haojun Yang, Hieu Sy Vu, Crystal S. Conn
Publikováno v:
Nature Metabolism. 3:244-257
Obesity is a global epidemic leading to increased mortality and susceptibility to comorbidities, with few viable therapeutic interventions. A hallmark of disease progression is the ectopic deposition of lipids in the form of lipid droplets in vital o
Autor:
Ichitaro Abe, Yasuo Oguri, Anthony R.P. Verkerke, Lauar B. Monteiro, Carly M. Knuth, Christopher Auger, Yunping Qiu, Gregory P. Westcott, Saverio Cinti, Kosaku Shinoda, Marc G. Jeschke, Shingo Kajimura
Publikováno v:
SSRN Electronic Journal.
Autor:
Futoshi Furuya, Yoshihito Fujita, Naomi Matsuo, Hiroto Minamino, Yasuo Oguri, Nozomi Isomura, Kaori Ikeda, Kohei Takesue, Ying Li, Aki Kondo, Fumika Mano, Nobuya Inagaki
Publikováno v:
EBioMedicine. 86
Sodium glucose co-transporter 2 (SGLT2) inhibitors are anti-diabetic drugs for type 2 diabetes that lower blood glucose levels and body weight. It is of special interest that SGLT2 inhibitors also improve liver metabolism and fatty liver. Liver is an
Autor:
Shingo Kajimura, Yasuo Oguri
Publikováno v:
J Clin Invest
Brown adipose tissue (BAT), as the main site of adaptive thermogenesis, exerts beneficial metabolic effects on obesity and insulin resistance. BAT has been previously assumed to contain a homogeneous population of brown adipocytes. Utilizing multiple